CAS: 536-46-9; N,N-Dimethyl-P-Phenylenediamine Dihydrochloride

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CAS号225091-66-7 3-amino-2-methy... | CAS号92-31-9 甲苯胺蓝O | CAS号18523-44-9 (4-dimethylamin... | CAS号58402-54-3 N,N-dimethyl-4-... | CAS号2150-58-5 N,N-二甲基吲哚苯胺 | CAS号22283-43-8 1-(4-(二甲氨基)苯基)硫脲 | CAS号3009-34-5 1,4-benzoquinon...

Methyl Red 在 铁粉,氯化铵体系中,用 乙醇,水作为反应溶剂,反应 0.25H,以85%的收率获得4-Dimethylaminophenylamine DihydroChloride
参考文献:A Simple Reduction Method Of Azo-Compounds To Amines Using Fe Powder In The Presence Of Nh4Cl
标题:A Simple Reduction Method Of Azo-Compounds To Amines Using Fe Powder In The Presence Of Nh4Cl
摘要:A Series Of Azo-Compounds Were Reduced To Related Aromatic Amines In The Presence Of Fe Powder And Ammonium Chloride. This One Step Protool Led To The Formation Of Products In Middle To High Yields,Especially When Electron Releasing Substituted Aromatic Azo-Compounds Were Reduced.
Doi:10.1007/S00706-007-0633-2

专利信息

专利号:US-7790881-B2
优先权日:2004-09-23
标 题:Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
发明人：STOREY JOHN MERVYN DAVID; SINCLAIR JAMES PETER; MARSHALL COLIN; TAN HAN WAN
权利人:WISTA LAB LTD
摘要:This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compoundsâ€?) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases. Wherein: each of R 1 and R 9 is independently selected from: —H; C 1-4 alkenyl; and halogenated C 1-4 alkyl; each of R 3NA and R 3NB is independently selected from: C 1-4 alkyl; C 2-4 alkenyl; and halogenated C 4-1 alkyl; each of R 7NA and R 7NB is independently selected from: C 1-4 alkyl; C 2-4 alkenyl; and halogenated C 1-4 alkyl; and X is one or more anionic counter ions to achieve electrical neutrality.

专利号:CN-119082067-A
优先权日:2024-09-12
标题:Artificial transaminase for synthesis of sitagliptin

专利号:US-2006287523-A1
优先权日:2004-09-23
标题:Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)

专利号:US-2008207603-A1
优先权日:2004-09-23
标题 :Methods of Chemical Synthesis and Purification of Diaminophenothiazinium Compounds Including Methylthioninium Chloride (Mtc)

专利号:US-9801890-B2
优先权日:2004-09-23
标题 :Medical methods utilising high purity diaminophenothiazinium compounds
发明人：STOREY JOHN MERVYN DAVID; SINCLAIR JAMES PETER; MARSHALL COLIN; TAN HAN WAN; WISCHIK CLAUDE MICHEL
权利人:WISTA LAB LTD
摘要:This disclosure pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compoundsâ€?) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt-formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallization (RX). Also disclosed resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.

专利号:JP-2012184244-A
优先权日:2004-09-23
标 题:Method for chemical synthesis and purification of diaminophenothiazinium compounds such as methylthioninium chloride (MTC)