专利号:EP-1383732-B1 优先权日:2001-05-04 标题:Labelling reagents, method for synthesis of said reagents and methods for detecting biological molecules 发明人:BOURGET CECILE; LHOMME JEAN; LAAYOUN ALI; KOTERA MITSUHARU; TREVISIOL EMMANUELLE; MENOU LIONEL; BERNAL MENDEZ ELOY 权利人:BIO MERIEUX; UNIV GRENOBLE 1; CENTRE NAT RECH SCIENT 摘要:The invention concerns a temperature-stable labelling reagent of formula (I), wherein: R<1> represents H or an alkyl, aryl or substituted aryl group; R<2> represents a detectable marker or at least two detectable markers linked together by at least a multimeric structure; L is a linking arm comprising a linear catemer concatenation of at least two covalent bonds; and n is an integer equal to 0 or 1; R<3> and R<4> represent, independently of each other: H, NO2, Cl, Br, F, I, R<2>-(L)n-Y-X-, OR, SR, NR2, R, NHCOR, CONHR, COOR with R = alkyl or aryl, A is a linking arm comprising at least a double bond enabling the conjugation of the diazo function with the aromatic cycle; and u is a whole number between 0 and 2, preferably between 0 and 1; and -Y-X- represents -CONH-, -NHCO-, -CH2O-, -CH2S-. The invention also concerns a method for the synthesis of said markers and uses for labelling biological molecules, in particular nucleic acids, with a labelling reagent bearing the diazomethyl function. The invention is particularly applicable in the field of diagnosis.
专利号:EP-1641729-B1 优先权日:2003-07-09 标题:Use of functionalized onium salts as a soluble support for organic synthesis 发明人:VAULTIER MICHEL; GMOUH SAID; HASSINE FATIMA 权利人:CENTRE NAT RECH SCIENT; UNIV RENNES 摘要:The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A1+, X1-, wherein A1+ represents a cation and X1- represents an anion.
专利号:US-5215997-A 优先权日:1985-09-11 标题:Synthesis of beta-lactam compounds 发明人:HUNGERBUEHLER ERNST; KALVODA JAROSLAV 权利人:CIBA GEIGY CORP 摘要:The invention relates to an improved process for the preparation of compounds of formula ##STR1## or salts thereof, starting from compounds of formulae ##STR2## via compounds of formulae ##STR3## in which compounds R 1 is hydrogen or lower alkyl, R 2 is an organic radical which may carry a functional group which may be protected by a customary protective group R 2 o , R 3 is hydrogen or a customary carboxyl protective group R 3 o , W is a group which can be replaced by a thiocarboxylic acid radical of formula III, and Z is oxygen or sulfur.
专利号:US-9045520-B2 优先权日:2008-12-23 标题:Synthesis of purine nucleosides 发明人:CHUN BYOUNG-KWON; DU JINFA; RACHAKONDA SUGUNA; ROSS BRUCE; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; CHANG WONSUK; ZHANG HAI-REN; NAGARATHNAM DHANPALAN 权利人:CHUN BYOUNG-KWON; DU JINFA; RACHAKONDA SUGUNA; ROSS BRUCE; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; CHANG WONSUK; ZHANG HAI-REN; NAGARATHNAM DHANPALAN; GILEAD PHARMASSET LLC 摘要:A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.
专利号:WO-2009005381-A1 优先权日:2007-06-29 标题 :The novel chiral triazole derivatives, synthesis and application thereof 发明人:BARYS MACIEJ; CIUNIK ZBIGNIEW; DRABENT KRZYSZTOF; SZPONAR BOGUMILA; GAMIAN ANDRZEJ 权利人:UNIV WROCLAWSKI; INST IMMUNOLOGII I TERAPII DOS; BARYS MACIEJ; CIUNIK ZBIGNIEW; DRABENT KRZYSZTOF; SZPONAR BOGUMILA; GAMIAN ANDRZEJ 摘要:The subject of the present invention are the triazole derivatives, the synthesis and application thereof. These are new compounds obtained in reaction of 4-amino- 1,2,4- triazole with nitrobenzaldehyde derivatives. Compounds possess two chiral centres that play the crucial role in chemical and biological properties. New triazole derivatives are used as active substances in drugs preventing and/or curing infection caused by fungi or bacteria.
专利号:US-9452425-B2 优先权日:2002-09-26 标 题 :Compositions containing ionic liquids and their uses, in particular in organic synthesis 发明人:VAULTIER MICHEL; GMOUH SAID 权利人:VAULTIER MICHEL; GMOUH SAID; CENTRE NAT RECH SCIENT; UNIV RENNES 摘要:An ionic liquid is used as liquid matrix for organic synthesis in homogeneous phase on soluble support, the ionic liquid being presented in liquid or solid form at ambient temperature, of formula A 1 + X 1 − , A 1 + representing a cation, functional or non-functional, or a mixture of cations in which either none of the cations is functional or at least one of the cations is functional, and X 1 − an anion, functional or non-functional, or a mixture of anions in which either none of the anions is functional or at least one of the anions is functional.
摘要:Krause, N.; Arisetti, N., Science of Synthesis Knowledge Updates, (2020) 3, 87. 摘要:Chemla, F.; Ferreira, F.; Pérez-Luna, A., Science of Synthesis Knowledge Updates, (2012) 1, 464. 摘要:Yliniemelä-Sipari, S. M.; Pihko, P. M., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 650. 摘要:Yliniemelä-Sipari, S. M.; Piisola, A.; Pihko, P. M., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 44. 摘要:Aggarwal, V. K.; McGarrigle, E. M.; Shaw, M. A., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 327.