📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醚,Magnesium Iodide,苯体系中,化学反应生成 香柑醇 参考文献:Furo-Chromones And-Coumarins (X): On The Constitution Of Prangenin 标题:Furo-Chromones And-Coumarins (X): On The Constitution Of Prangenin 摘要: DOI:10.1021/ja01614A068
专利号:US-6734313-B2 优先权日:2000-10-20 标题 :Synthesis of spiro esters, spiro ortho carbonates, and intermediates 发明人:SEEMAYER ROBERT; LIANG JACK 权利人:BIOAVAILABILITY SYSTEMS LLC 摘要:Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.
专利号:US-6613918-B1 优先权日:2000-10-20 标 题 :Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates 发明人:SEEMAYER ROBERT; LIANG JACK 权利人:BIOAVAILABILITY SYSTEMS LLC 摘要:Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.
专利号:US-4429138-A 优先权日:1977-10-21 标题 :Process for the synthesis of 5-methoxy-psoralen 发明人:GOUPIL JEAN-JACQUES 权利人:GOUPIL JEAN JACQUES 摘要:A pharmaceutical formulation comprising 5-methoxy psoralen, which is useful in the treatment of psoriasis and other skin disorders, is disclosed herein. 5-Methoxy psoralen may be synthesized from phloroglucinol by a five step process which is also disclosed.
专利号:CN-110184247-B 优先权日:2019-05-09 标 题:Melatonin synthesis gene MsASMT in alfalfa and its application in regulating the synthesis of melatonin and flavonoids in plants
专利号:US-7772408-B1 优先权日:2002-08-29 标 题 :Substituted 5-alkoxypsoralens as inhibitors of potassium channel activity in lymphocytes and other cells 发明人:VENNEKAMP JULIA; WULFF HEIKE; CHANDY K GEORGE; GRISSMER STEPHAN; HANSEL WOLFRAM 权利人:UNIV CALIFORNIA 摘要:Compositions of matter comprising 5-phenylalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or veterinary patients, including autoimmune diseases such as multiple sclerosis. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition.
专利号:US-2004002611-A1 优先权日:2000-10-20 标 题:Synthesis of spiro esters, spiro ortho carbonates, and intermediates
1: Girennavar B, Jayaprakasha GK, Jadegoud Y, Nagana Gowda GA, Patil BS. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorg Med Chem. 2007 Jun 1;15(11):3684-91. Epub 2007 Mar 18. doi: 10.19540/j.cnki.cjcmm.20161222.017. Chinese. doi: 10.3389/fpls.2016.00722. eCollection 2016. 4: Ishikawa A, Kuma T, Sasaki H, Sasaki N, Ozeki Y, Kobayashi N, Kitamura Y. Constitutive expression of bergaptol O-methyltransferase in Glehnia littoralis cell cultures. Plant Cell Rep. 2009 Feb;28(2):257-65. doi: 10.1007/s00299-008-0631-9. Epub 2008 Oct 31. doi: 10.1021/acs.jafc.7b00317. Epub 2017 Mar 29. doi: 10.1080/09637486.2016.1207157. Epub 2016 Jul 10. doi: 10.1016/j.fct.2011.09.005. Epub 2011 Sep 12. Italian. Epub 2012 Jul 7. doi: 10.1002/ptr.5490. Epub 2015 Oct 14. doi: 10.1016/j.fct.2011.11.023. Epub 2011 Dec 3. 15: Yang YF, Zhang L, Zhang YB, Yang XW. Simultaneous assessment of absorption characteristics of coumarins from Angelicae Pubescentis Radix: In vitro transport across Caco-2 cell and in vivo pharmacokinetics in rats after oral administration. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Aug 15;1060:308-315. doi: 10.1016/j.jchromb.2017.06.020. Epub 2017 Jun 13. doi: 10.1002/cbdv.201700447. Epub 2017 Dec 21. Chinese. doi: 10.4103/pm.pm_49_17. Epub 2017 Oct 11.
合成参考文献
参考文献:10.4103/0019-5154.82498 摘要:Zhang R, Zhu W. Phytophotodermatitis due to chinese herbal medicine decoction. Indian J Dermatol. 2011 May;56(3):329–31.