CAS: 486-60-2; 4-Hydroxy-7H-Furo[3,2-G]Chromen-7-One

该化合物是天然存在的化合物,被归类为呋喃,主要存在于各种植物中,特别是柑橘家族,以其潜在的生物活动著称.该物质呈现黄色晶状,在乙醇和甲醇等有机溶剂中可溶解,但水溶性有限.Bergaptol由于报告的抗氧化剂,抗炎和抗微生物特性,对药理学产生了兴趣.此外,还研究了该物质在光毒性方面的潜在作用,因为它能对紫外光线产生敏化作用.该物质的结构具有铬质骨的特征,这是许多呋喃的特征,有助于其生物效应的多样性.与许多天然产品一样,甲酸盐的提取和净化可能具有挑战性,其稳定性可能受到光和温度等环境因素的影响.

结构式图片

欧盟法规

C&L通报

上下游产品

CAS号484-20-8 佛手柑内酯 | CAS号88206-46-6 羌活醇 | CAS号88206-49-9 Notoptol | CAS号482-45-1 异欧前胡素 | CAS号131623-13-7 Bergaptol O-β-D... | CAS号89787-38-2 7H-Furo[3,2-g][... | CAS号264234-05-1 6',7'-二羟薄荷素 | CAS号7380-40-7 佛手柑素 | CAS号482-48-4 异佛手柑内酯 | CAS号484-20-8 佛手柑内酯 | CAS号482-45-1 异欧前胡素 | CAS号870653-45-5 5-(4-苯氧基丁氧基)补骨脂... | CAS号737-52-0 氧化前胡素 | CAS号7380-40-7 佛手柑素 | CAS号145414-76-2 二羟基香柠檬素 | CAS号2643-85-8 水合氧化前胡素 | CAS号87997-40-8 (7-oxofuro[3,2-... | CAS号483-36-3 Psoralen quinone

合成工艺路线路线简述

  • 合成目标产物 Bergaptol 主要起始原料 Bergaptol
  • (文献来源)合成步骤主要原料 Bergaptol
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醚,Magnesium Iodide,苯体系中,化学反应生成 香柑醇
参考文献:Furo-Chromones And-Coumarins (X): On The Constitution Of Prangenin
标题:Furo-Chromones And-Coumarins (X): On The Constitution Of Prangenin
摘要:
DOI:10.1021/ja01614A068

海关参考信息

专利信息


专利号:US-6734313-B2
优先权日:2000-10-20
标题 :Synthesis of spiro esters, spiro ortho carbonates, and intermediates
发明人:SEEMAYER ROBERT; LIANG JACK
权利人:BIOAVAILABILITY SYSTEMS LLC
摘要:Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.

专利号:US-6613918-B1
优先权日:2000-10-20
标 题 :Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates
发明人:SEEMAYER ROBERT; LIANG JACK
权利人:BIOAVAILABILITY SYSTEMS LLC
摘要:Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.

专利号:US-4429138-A
优先权日:1977-10-21
标题 :Process for the synthesis of 5-methoxy-psoralen
发明人:GOUPIL JEAN-JACQUES
权利人:GOUPIL JEAN JACQUES
摘要:A pharmaceutical formulation comprising 5-methoxy psoralen, which is useful in the treatment of psoriasis and other skin disorders, is disclosed herein. 5-Methoxy psoralen may be synthesized from phloroglucinol by a five step process which is also disclosed.

专利号:CN-110184247-B
优先权日:2019-05-09
标 题:Melatonin synthesis gene MsASMT in alfalfa and its application in regulating the synthesis of melatonin and flavonoids in plants

专利号:US-7772408-B1
优先权日:2002-08-29
标 题 :Substituted 5-alkoxypsoralens as inhibitors of potassium channel activity in lymphocytes and other cells
发明人:VENNEKAMP JULIA; WULFF HEIKE; CHANDY K GEORGE; GRISSMER STEPHAN; HANSEL WOLFRAM
权利人:UNIV CALIFORNIA
摘要:Compositions of matter comprising 5-phenylalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or veterinary patients, including autoimmune diseases such as multiple sclerosis. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition.

专利号:US-2004002611-A1
优先权日:2000-10-20
标 题:Synthesis of spiro esters, spiro ortho carbonates, and intermediates

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Girennavar B, Jayaprakasha GK, Jadegoud Y, Nagana Gowda GA, Patil BS. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorg Med Chem. 2007 Jun 1;15(11):3684-91. Epub 2007 Mar 18. doi: 10.19540/j.cnki.cjcmm.20161222.017. Chinese. doi: 10.3389/fpls.2016.00722. eCollection 2016.
4: Ishikawa A, Kuma T, Sasaki H, Sasaki N, Ozeki Y, Kobayashi N, Kitamura Y. Constitutive expression of bergaptol O-methyltransferase in Glehnia littoralis cell cultures. Plant Cell Rep. 2009 Feb;28(2):257-65. doi: 10.1007/s00299-008-0631-9. Epub 2008 Oct 31. doi: 10.1021/acs.jafc.7b00317. Epub 2017 Mar 29. doi: 10.1080/09637486.2016.1207157. Epub 2016 Jul 10. doi: 10.1016/j.fct.2011.09.005. Epub 2011 Sep 12. Italian. Epub 2012 Jul 7. doi: 10.1002/ptr.5490. Epub 2015 Oct 14. doi: 10.1016/j.fct.2011.11.023. Epub 2011 Dec 3.
15: Yang YF, Zhang L, Zhang YB, Yang XW. Simultaneous assessment of absorption characteristics of coumarins from Angelicae Pubescentis Radix: In vitro transport across Caco-2 cell and in vivo pharmacokinetics in rats after oral administration. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Aug 15;1060:308-315. doi: 10.1016/j.jchromb.2017.06.020. Epub 2017 Jun 13. doi: 10.1002/cbdv.201700447. Epub 2017 Dec 21. Chinese. doi: 10.4103/pm.pm_49_17. Epub 2017 Oct 11.

合成参考文献


参考文献:10.4103/0019-5154.82498
摘要:Zhang R, Zhu W. Phytophotodermatitis due to chinese herbal medicine decoction. Indian J Dermatol. 2011 May;56(3):329–31.
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