CAS: 3819-88-3; 1-Fluoro-3-Iodo-5-Nitrobenzene

上下游产品

meta-dinitrobenzene 3-nitro-5-iodoaniline 4-fluoro-2-nitrobenzoic acid 3-fluoro-5-iodoaniline 3-fluoro-5-nitrobenzonitrile 3-fluoro-5-piperazin-1-yl-benzonitrile 1-(3-fluoro-5-iodophenyl)piperazine

5-Iod-3-Nitro-1-Diazonio-Benzol 反应生成1-氟-3-碘-5-硝基苯
参考文献:Derivatives Of Fluorene. X. Fluorofluorenes. Iii1
标题:Derivatives Of Fluorene. X. Fluorofluorenes. Iii1
摘要:
Doi:10.1021/jo01078A015

专利信息

专利号:US-6552018-B1
优先权日:1997-01-27
标 题:Pyrazole derivatives
发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
权利人:DAIICHI SEIYAKU CO
摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.