CAS: 37669-78-6; Ethyl 2,4-Dimethylnicotinate

相似化合物

55314-30-2 194151-96-7 168072-32-0

上下游产品

2,4-dimethyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 1-amino-1-buten-3-one ethyl acetoacetate 2,4,6-Trimethyl-[1,3,5]triazinane; hydrate3-Acetyl-2,4-dimethylpyridin 2,4-dimethylnicotinic acid (2,4-dimethylpyridin-3-yl)-methanol 4,4',6,6'-tetramethyl-5,5'-bis[(S)-(-)-1-phenylethylcarbamoyl]-2,2'-bipyridine

3-氨基巴豆酸乙酯置于哌啶,Ammonium Cerium(Iv) Nitrate体系中,用 乙醇,丙酮 作为反应溶剂,化学反应 3.33H,反应生成 乙基2,4-二甲基吡啶-3-羧化物
参考文献:非肽血管紧张素ii受体拮抗剂.i.吡啶衍生物的合成和生物活性.
标题:非肽血管紧张素ii受体拮抗剂.i.吡啶衍生物的合成和生物活性.
摘要:取代的吡啶被合成为潜在的血管紧张素ii(aii)受体拮抗剂.在吡啶的2位取代导致有效的活性,并且最佳的烷基长度为四个碳.随着在位置4处引入羟甲基的影响,效力进一步提高.化合物之一是2-丁基-6-氯-4-氯甲基-4-羟甲基-5-甲基-3-[[2'-(1H-四唑-5)-Yl)联苯基-4-Yl]甲基]吡啶9 H(kt3-579)是竞争性aii拮抗剂,Pa2值为9.31,效力是du Pont 753的约10倍.发现它是at1特异性拮抗剂,Ic50为3.09 Nm.
DOI:10.1248/cpb.42.1841

专利信息

专利号:US-6818773-B2
优先权日:2001-10-15
标题:Synthesis of 4-[(Z)-4-bromophenyl)(ethoxyimino) methyl]-1'-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbony)]-4'-methyl-1,4-′bipiperidine
发明人：CHEN MINZHANG; D SA BOSCO ANTHONY; LEONG WILLIAM W; GAN TONG; WONG GEORGE S K; TANG SUHAN; NIELSEN CHRISTOPHER MICHAEL
权利人:SCHERING CORP
摘要:In one embodiment, the present invention describes the synthesis of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1'-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbonyl]-4'-methyl-1,4'-bipiperidine, and intermediates therefor from easily available starting materials by a simple route.

专利号:US-6992189-B2
优先权日:2002-03-29
标 题 :Synthesis of piperidine and piperazine compounds as CCR5 antagonists
发明人：LEONG WILLIAM; CHEN MINZHANG; D SA BOSCO A; ZHU MAN; XIAO TONG; SHI XIONGWEI; TANG SUHAN; GALA DINESH; GOODMAN ANDREW J; NIELSEN CHRISTOPHER M; LEE GARY M; GAMBOA JUAN A; JONES ANDREW D
权利人:SCHERING CORP
摘要:In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:

专利号:US-2004024217-A1
优先权日:2002-03-29
标题 :Synthesis of piperidine and piperazine compounds as CCR5 antagonists

专利号:US-10112955-B2
优先权日:2015-10-29
标题 :Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
发明人：SPRENGELER PAUL A; REICH SIEGFRIED H; ERNST JUSTIN T; WEBBER STEPHEN E; SHAGHAFI MIKE; MURPHY DOUGLAS; TRAN CHINH
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds A 1 , A 2 , A 3 , A 4 , A 5 , W 1 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b , and R 10 and subscript “nâ€? are as defined in the specification. The inventive Formula I compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:JP-2005521743-A
优先权日:2002-03-29
标 题 :Synthesis of piperidine and piperazine compounds as CCR5 antagonists

专利号:US-2005187248-A1
优先权日:2002-03-29
标题 :Synthesis of piperidine and piperazine compounds as CCR5 antagonists