CAS: 37148-27-9; Clenbuterol

上下游产品

4'-amino-2-(t-butylamino)-3',5'-dichloroacetophenone hydr°Chloride rac-1-(4-aminophenyl)-2-(tert-butylamino)ethanol 2-(4-amino-3,5-dichlorophenyl)-N-(tert-butyl)-2-oxoacetamide 2,6-dichloro-4-iodoanilineN-[2-(4-Amino-3,5-dichloro-phenyl)-2-(1,2-dimethyl-propyl-dimethyl-silyloxy)-ethyl]-N-t-butylamine 5-(4-amino-3,5-dichlorophenyl)-3-tert-butyl-2-oxazolidinone (+)-Clenbuterol

📜2,6-二氯-4-碘苯胺置于sodium Tetrahydroborate,三叔丁基膦,N-甲基二环己基胺,碘,Bis(Dibenzylideneacetone)-Palladium(0)体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 16.0H,反应生成 克仑特罗
参考文献:使用接近化学计量的一氧化碳进行钯催化的双羰基化:方便地获得取代的13 C 2标签的苯乙胺
标题:使用接近化学计量的一氧化碳进行钯催化的双羰基化:方便地获得取代的13 C 2标签的苯乙胺
摘要:基于高度收敛的碳骨架一步组装,已开发出一种新颖且通用的13 C 2-和2 H标记的苯乙胺衍生物的方法.使用钯催化的具有接近化学计量的一氧化碳的芳基碘化物的双羰基化作用,可以将两个碳13同位素有效地结合到苯乙胺中.
DOI:10.1021/jo3009337

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人：BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:US-8017776-B2
优先权日:2003-07-15
标题 :Methods for synthesis of acyloxyalkyl compounds
发明人：BHAT LAXMINARAYAN; GALLOP MARK A
权利人:XENOPORT INC
摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

专利号:US-8143437-B2
优先权日:2002-02-19
标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
发明人：GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X
权利人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X; XENOPORT INC
摘要:The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.

专利号:US-9757463-B2
优先权日:2012-06-15
标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
发明人：HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M
权利人:UNIV VANDERBILT
摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-2006165683-A1
优先权日:2001-12-05
标题:Methods and compositions for control of bone formation via modulation of sympathetic tone
发明人：KARSENTY GERARD; TAKEDA SHU; ELEFTERIOU FLORENT
权利人:KARSENTY GERARD; TAKEDA SHU; ELEFTERIOU FLORENT
摘要:This invention relates to methods for treatment, diagnosis and prevention of bone disease and comprises methods including measurement and modulation of sympathetic tone and leptin activity. Alteration of sympathetic tone in bone disease can be accomplished by decreasing or increasing leptin synthesis, leptin receptor synthesis, leptin binding to the leptin receptor, and leptin receptor activity. Alteration of sympathetic tone in bone disease can also be accomplished in the foregoing manner, in combination with traditional sympathetic nervous system agonists and/or antagonists, such as, but not limited to, a dopamine β hydroxylase antagonist or a β adrenergic antagonist for treatment or prevention of osteoporosis.