CAS: 28610-31-3; 8-Prenylkaempferol
该化合物是一种以其潜在药理特性而闻名的生物活性叶素,是Icaritin的脱甲基衍生物,具有更强的生物利用率和代谢稳定性;研究表明其作为选择性雌激素受体摩托器的作用,其应用在骨骼健康和骨质动物研究方面的应用;此外,它还展示了抗炎和抗舌质活动,特别是在肝细胞癌研究中;其分子结构使与细胞目标的相互作用与母体化合物相比得到改善;Desmothy Icaritin有兴趣对其潜在的治疗效果进行临床前研究,为进一步调查药物开发和营养应用提供了有前途的候选者.
- 英文名称8-Prenylkaempferol
- 中文名称去甲脱水淫羊藿黄素
- IUPAC名称Desmethylicaritin
- 其它别名0V5Xk67Y0S; 3,5,7-Trihydroxy-2-(4-Hydroxyphenyl)-8-(3-Methylbut-2-En-1-yl)-4H-Chromen-4-One; Desmethyl Icaritin; De-O-Methylanhydroicaritin; 3,5,7-Trihydroxy-2-(4-Hydroxyphenyl)-8-(3-Methyl-2-Buten-1-yl)-4H-1-B
- CAS编号28610-31-3
- MFCD编号:MFCD18379337
- FDA UNII编号:0V5XK67Y0S
- 分子式:C20H18O6分子量:354.36
- 产品CID: 1266512
- 产品分类天然产物 → 黄酮类化合物
物理性质
上下游产品
5-hydroxy-8-prenyl-3,4',7-tris-O-methoxymethylkaempferol kaempferol dimethylallyl diphosphate 7,4'-bis-O-methoxymethyl-8-prenylkaempferolkaempferol icaritin 6,6-dimethyldihydropyran (2,3:7,8)-5,4'-dihydroxyflavonol 8-(3-hydroxy-3-methylbutyl)-5,7,4'-trihydroxyflavonol合成工艺路线路线简述
- 合成目标产物 Desmethylanhydroicaritin 主要起始原料 2',4',6'-Trihydroxyacetophenone Monohydrate
- (文献来源)合成步骤主要原料 2',4',6'-Trihydroxyacetophenone Monohydrate
📜山奈酚置于盐酸,四丁基氢氧化铵,N,N-二异丙基乙胺,N,N-二乙基苯胺体系中,用 甲醇,二氯甲烷,N,N-二甲基甲酰胺,甲苯 用作溶剂,化学反应生成去甲脱水淫羊藿黄素
参考文献:Effects Of Flavonoids On Cell Proliferation And Caspase Activation In A Human Colonic Cell Line Ht29: An Sar Study
标题:Effects Of Flavonoids On Cell Proliferation And Caspase Activation In A Human Colonic Cell Line Ht29: An Sar Study
摘要:A Library Of 42 Natural And Synthetic Flavonoids Has Been Screened For Their Effect On Cell Proliferation And Apoptosis In A Human Colonic Cell Line (Ht-29). Examples Of Different Classes Of Flavonoids Have Been Screened,And The Effects Of Hydroxylation,Methoxylation And/or C-Alkylation At Various Positions In The A-And B-Rings Have Been Assessed. Flavones And Flavonols Possess Greater Antiproliferative Activity Than Chalcones And Flavanones. With Respect To Structural Modification Of Flavonoids,C-Isoprenylation Was By Far The Most Effective,With Substitution At The 8-Position And Longer Chains,Such As Geranyl Giving The Best Results. Finally,Most Compounds That Significantly Reduced Cell Survival Also Increased Caspase Activity,Suggesting That At Least Part Of Their Antiproliferative Activity Might Be Attributable To An Apoptotic Response.
Doi:10.1021/jm040770B
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2907221000-对苯二酚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:EP-4251758-A1
优先权日:2020-11-25
标 题:Polypeptides for use in the synthesis of bioactive phenolic compounds
专利号:CA-3202377-A1
优先权日:2020-11-25
标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Wu H, Kim M, Han J. Icariin Metabolism by Human Intestinal Microflora. Molecules. 2016 Aug 31;21(9). pii: E1158. doi: 10.3390/molecules21091158. doi: 10.1055/s-0033-1360112. Epub 2013 Dec 5. doi: 10.1016/j.ejphar.2013.06.008. Epub 2013 Jun 20. doi: 10.1002/jcp.24158. Review. doi: 10.1016/j.jpba.2012.03.053. Epub 2012 Apr 5. doi: 10.1002/jssc.201000899. Epub 2011 May 10. doi: 10.1016/j.jpba.2009.04.022. Epub 2009 May 3. doi: 10.1016/j.jchromb.2008.11.030. Epub 2008 Nov 27. Epub 2007 Jul 1. Chinese.
合成参考文献
参考文献:10.1055/s-2005-871302
摘要:Hillerns PI, Wink M. Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor. Planta Med. 2005 Nov;71(11):1065–8. doi: 10.1055/s-2005-871302.
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