CAS: 2623-82-7; 2-Bromooctanoic Acid

相似化合物

18263-25-7 142-94-9 5445-29-4

上下游产品

°Ctanoic acid (2-Bromo-°Ctyloxy)-trimethyl-silane n-°Ctanoic acid chloride 1,2-Epoxy°Ctane methyl 2-bromo°Ctanoate 2-amino°Ctanoic acid ethyl-2-bromo°Ctanoate (1)2-Benzaminooxy-°Ctansaeure-(1)

辛酸置于溴,三氯化磷体系中,化学反应 5.0H,以56%的收率获得2-溴正辛酸
参考文献:对映选择性合成tetrahydrolipstatin Synthon的酶促胶凝策略.
标题:对映选择性合成tetrahydrolipstatin Synthon的酶促胶凝策略.
摘要:已经制定了一种新颖的脂肪酶催化方案,用于在柔性无环系统中同时控制三个立体生成中心.这涉及猪胰脂肪酶(ppl)催化的外消旋3,5-二羟基-2-烷基酯的δ-内酯化,以产生具有高对映选择性(92.8%)的内酯.内酯产物及其类似物是有用的合成子,用于各种生物活性化合物的不对称合成,其中包括潜在的抗肥胖化合物四氢脂肪抑制素.
Doi:10.1021/jo990370+

专利信息

专利号:US-5420305-A
优先权日:1991-07-23
标题:Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4 (3H)-dione
发明人：RAMIG KEITH M; LANDI JR JOHN J
权利人:HOFFMANN LA ROCHE
摘要:A process for the preparation of a tautomeric mixture of compounds of the formulas ##STR1## wherein W is hydrogen or C 6 H 13 , which comprises treating a compound of the formula ##STR2## wherein R is unsubstituted or substituted alkoxy, arylalkoxy, aryloxy or amine and R 1 is hydrogen or when R is alkoxy, substituted alkoxy, substituted amine, unsubstituted or substituted arylalkoxy R 1 can also be metal, with a compound of the formula ##STR3## wherein W is as described above, both X and Y are reducible groups or X is hydrogen and Y is a reducible group or Y is hydrogen and X is a reducible group and, Z is hydroxy or a leaving group to form the compound of formula IV ##STR4## wherein W, X, Y and R are as defined above, the compound of formula IV is treated with a low valent metal to form a tautomeric mixture of compounds of formulas I and Ia, which are useful in the synthesis of tetrahydrolipstatin.

专利号:CN-114349739-A
优先权日:2021-12-14
标 题 :A kind of azo compound that degrades tubulin and its synthesis method and application