CAS: 219543-69-8; 4-Hydroxy-5-Nitropyrimidine
该化合物是一种七环有机化合物,其特点是在4级和5级中以一个羟基组取代一个环状环状,在4级和硝基体组状中,该化合物一般是晶状固体,可溶于极地溶剂,因为有氢氧化物组,可从事氢结合;硝基化合物组有助于其再活动,成为各种化学反应,包括核生殖替代和减少的潜在候选体;4-Hydroxy-5-nitiropyrimidine可能展示生物活动,这可能会对药物研究,特别是抗微生物剂或抗癌剂的研制具有兴趣;其分子结构允许与生物目标发生潜在互动,使其成为医药化学研究的主题;应参考安全数据处理和储存,因为硝基化合物可能敏感并可能构成健康风险.
相似化合物
53925-27-2 2164-83-2 3749-47-1物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2904209090-其他仅含硝基或亚硝基衍生物
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专利信息
专利号:WO-0123361-A1
优先权日:1999-09-27
标题 :Pyrimidine derivatives, process for preparing the derivatives and drugs containing the same as the active ingredient
发明人：KOJIMA TSUTOMU; OKADA TAKANORI; HACHIYA KATSUTOSHI; MOTOI TAKAHIRO; HASHIMOTO SHINSUKE
权利人:ONO PHARMACEUTICAL CO; KOJIMA TSUTOMU; OKADA TAKANORI; HACHIYA KATSUTOSHI; MOTOI TAKAHIRO; HASHIMOTO SHINSUKE
摘要:Pyrimidine derivatives of general formula (I) or nontoxic salts thereof, useful as intermediates for the synthesis of drugs and/or as drugs, particularly elastase inhibitors. In formulas (I) and (II) R1 is H or F; R2 is -CH(OR3)2, CHO, COOH, alkoxycarbonyl, furan-2-yl, a group of general formula (II), or the like; R3 is Me or Et; and R4 is alkyl, phenyl, (substituted) benzyl, or the like.
专利号:JP-H06316576-A
优先权日:1983-04-11
标题 :Synthesis of 6,6-di-substituted dihydropteridine
专利号:CN-101838207-A
优先权日:2006-08-24
标 题 :Intermediates of Entecavir and synthesis method thereof
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合成参考文献
参考文献:10.1007/bf00504191
摘要:Rusinov VL, Petrov AY, Chupakhin ON. Nitroazines. Methods of synthesis (review). Chemistry of Heterocyclic Compounds. 1985 Feb;21(2):113–31. doi: 10.1007/bf00504191.
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