CAS: 191729-43-8; (1R,3Ar,4As,6As,8S,10As,10Bs,11S,12S,12As)-12-Acetoxy-1-Acetyl-8-(((2R,4R,5R,6R)-5-(((2S,3R,4R,5R,6R)-3,5-Dihydroxy-4-Methoxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-4-Methoxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-10A,12A-Dimethyltetradecahydro-1H-Cyclopenta[1,2]Phenanthro[1,10A-B]Oxiren-11-Yl (E)-2-Methylbut-2-Enoate
该化合物是一个生物活性血清激素基体,与长期用于草药的Mardenia tencisima植物隔离开来,该化合物具有显著的药理特性,包括抗炎,免疫化学和潜在的抗肿瘤活动,其行动机制包括调制NF-B和MAPK等信号路径,使其成为肿瘤学和免疫学研究的一个主题.Tanacissoside G的特点是高度纯度和稳定性,确保实验应用的可靠性能.其明确界定的结构和持续生物利用率进一步提高了其作为药物和生物化学研究参考标准或调查工具的效用.
- 英文名称(1R,3Ar,4As,6As,8S,10As,10Bs,11S,12S,12As)-12-Acetoxy-1-Acetyl-8-(((2R,4R,5R,6R)-5-(((2S,3R,4R,5R,6R)-3,5-Dihydroxy-4-Methoxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-4-Methoxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-10A,12A-Dimethyltetradecahydro-1H-Cyclopenta[1,2]Phenanthro[1,10A-B]Oxiren-11-Yl (E)-2-Methylbut-2-Enoate
- 中文名称通关藤苷G
- IUPAC名称(1R,3aR,4aS,6aS,8S,10aS,10bS,11S,12S,12aS)-12-acetoxy-1-acetyl-8-(((2R,4R,5R,6R)-5-(((2S,3R,4R,5R,6R)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10a,12a-dimethyltetradecahydro-1H-cyclopenta[1,2]phenanthro[1,10a-b]oxiren-11-yl (E)-2-methylbut-2-enoate
- 其它别名Tenacissoside G; (3Beta,5Alpha,11Alpha,12Beta,14Beta,17Alpha)-12-(Acetyloxy)-3-[[2,6-Dideoxy-4-O-(6-Deoxy-3-O-Methyl-Beta-D-Allopyranosyl)-3-O-Methyl-Beta-D-Arabino-Hexopyranosyl]Oxy]-8,14-Epoxy-11-[[(2E)-2-Methyl-1-Oxo-2-Buten-1-Yl]Oxy]Pregnan-20-One; Tenacissimoside A; Nacissoside G; Pregnan-20-One, 12-(Acetyloxy)-3-[[2,6-Dideoxy-4-O-(6-Deoxy-3-O-Methyl-β-D-Allopyranosyl)-3-O-Methyl-β-D-Arabino-Hexopyranosyl]Oxy]-8,14-Epoxy-11-[[(2E)-2-Methyl-1-Oxo-2-Buten-1-Yl]Oxy]-, (3β,5α,11α,12β,14β,17α)-; Tenacissoside Impurity 1; Tenacissoside G, 10 Mm In Dmso; Tecissoside G
- CAS编号191729-43-8
- MFCD编号:MFCD22417326
- 分子式:C42H64O14分子量:792.96
- 产品CID: 971354
- 产品分类天然产物 → 甾体化合物
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
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📌 第三方产品分析报告
合成参考文献
参考文献:10.1021/np070458f
摘要:Hu YJ, Shen XL, Lu HL, Zhang YH, Huang XA, Fu LC, Fong WF. Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells. J Nat Prod. 2008 Jun;71(6):1049–51. doi: 10.1021/np070458f.
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