专利号:WO-2024165885-A1 优先权日:2023-02-06 标 题 :Microfluidic device for the synthesis of micro and nanoproducts and method of manufacturing said microfluidic device 发明人:POLICASTRO LUCÃ?A LAURA; CABALEIRO JUAN MARTÃ?N; SORAIRES SANTACRUZ MARÃ?A CRISTINA; SANMARCO ELENA MARÃ?A; BENAVIDES CASTILLO LISBETH ALEXANDRA 权利人:COMISION NAC DE ENERGIA ATOMICA; CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECN; FERNANDEZ PEREZ BANI RAQUEL 摘要:Microfluidic device for the synthesis of micro and nanoproducts and manufacturing method of said microfluidic device. The microfluidic device comprises a top piece made of photopoly- merizable resin, which in turn comprises at least two inlet holes and at least one outlet hole; one or more bottom pieces made of photopolymerizable resin, which in turn comprise microchannels; and fastening means between the top piece and the bottom piece or bottom pieces. The manu- facturing method comprises a step of modeling the pieces of the microfluidic device; a 3D printing stage of the pieces of the microfluidic device; a post-processing stage of the pieces of the microfluidic device; and a stage of assembling of the microfluidic device.
专利号:US-6717007-B1 优先权日:1999-09-16 标 题:Regiospecific synthesis of phosphonous acids 发明人:DUBEY SUSHIL KUMAR; RAJGOPAL VENKAT; SINGH ANIL VIR; LAHIRI SASWATA; WANI MUKESH JAGANNATH 权利人:LUPIN LTD 摘要:An improved regiospecific synthesis of organic phosphonous acids, comprising of hydrophosphorylation of an olefin with hydrophosphorous acid in the presence of an inorganic persulfate, which acts as a source of free radicals at a pH ranging from 4.5 to 7.0, in which the orientation of addition is anti-Markonikoff. The process enables production of organic phosphonous acids at lower temperature and atmospheric pressure under milder pH conditions for better regioselectivity in hydrophosphorylation and obtain the phosphonous acid with good yield and purity following simple isolation procedure. Phosphonous acids obtained by the process are commercially valuable as effective detergents and wetting agents, lubricants and lubricant additives, plasticizers for plastics and resins, corrosion inhibitors, chemicals including insecticides and pesticides, cobalt extractants and as key intermediates for preparation of commercially important angiotensin converting enzyme (ACE) inhibitors.
专利号:US-11873315-B2 优先权日:2017-06-16 标 题 :Chiral n-heterocyclic phosphorodiamidic acids (NHPAS) and derivatives as novel Brønsted acid catalysts 发明人:KANG JUN YONG; HUANG HAI 权利人:The Board of Regents of the Nevada System of Higher Education on Behalf of the Univ of Nevada; THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE 摘要:Provided herein are diaryl and arylalkyl phosphonates, useful as intermediates in, for example, the synthesis of leukocyte elastase inhibitors, potassium channel modulators, chemiluminescence materials, and flame retardants, and methods for making same. Also provided are N-heterocyclic phosphorodiamidic acids (NHPAs) useful in reactions such as, for example, in the preparation of diaryl and arylalkyl phosphonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:US-4204997-A 优先权日:1979-03-19 标题 :Asymmetric amination of 1,3-dienes 发明人:HOBBS CHARLES F; MCMACKINS DUDLEY E 权利人:MONSANTO CO 摘要:A process for the asymmetric synthesis of amines which comprises the amination of a conjugated diene having from 4 to about 20 carbon atoms in the presence of a catalyst system comprising a palladium compound and an optically active phosphine ligand containing at least two phosphorus atoms.
专利号:US-2019202750-A1 优先权日:2016-07-01 标 题 :Synthesis of nanocomposites and their use in enhancing plant nutrition
专利号:US-2004138495-A1 优先权日:1997-10-09 标题:Combinatorial preparation of phosphorus-containing active compounds and intermediates by solid phase synthesis 发明人:HAAF KLAUS; PATEK MARCEL 权利人:HAAF KLAUS; PATEK MARCEL 摘要:The invention relates to solid phase processes for the systematic preparation of chemical compounds from the group of the phosphonous or phosphinic acids and/or derivatives thereof and the corresponding substance libraries which can be employed for test purposes, in particular tests for biological activity. The compounds n YR 1 P(â•?O)(OR 3 )R 2   (I) n in which Y, R 1 , R 2 , R 3 are as defined in claim 1 are prepared by reacting a resin-linker adduct (II) n [resin polymer]-[linker-Z-E 1 -S 1 ] n n in the presence of a suitable Pd catalyst with a phosphinate (III) n A 1 -O—(PHO)A â–¡   (III) n with substitution of the group S 1 to give the compound (IV) n [resin polymer]-[linker-Z-E 1 -P(H)(â•?O)—OA 1   (IV) n and cleaving the compound (I) after derivatization reactions on the resin from the resin-linker adduct. n The invention also provides the intermediate steps and resin-linked intermediate compounds and also the substance libraries obtained.
摘要:Summary Tables of Biological Tests, National Research Council Chemical-Biological Coordination Center., 2(56), 1950 摘要:National Technical Information Service., OTS0555311 摘要:Alajarín, M.; López-Leonardo, C.; Berná, J., Science of Synthesis, (2007) 31, 2116.