CAS: 156928-09-5; (3R,3As,6Ar)-Hexahydrofuro[2,3-B]Furan-3-Ol

相似化合物

109789-19-7 252873-50-0 156928-10-8

上下游产品

(3S,3As,6Ar)-Hexahydrofuro[2,3-B]Furan-3-Ol
六氢-呋喃并[2,3-B]呋喃-3-醇 Hexahydrofuro[2,3-B]Furan-3-Ol 109789-19-7
(3S,3Ar,6As)-六氢呋喃并[2,3-B]呋喃-3-醇 (3S,3Ar,6As)-Hexahydrofuro[2,3-B]Furan-3-Ol 156928-10-8
(3S,3As,6Ar)-六氢呋喃并[2,3-B]呋喃-3-醇 (3S,3As,6Ar)-Hexahydrofuro[2,3-B]Furan-3-Ol 252873-50-0
(+/-)-Hexahydrofuro[2,3-B]Furan-3-Ol 109789-19-7
(3R,4S)-4-(2-羟乙基)-5-甲氧基四氢呋喃-3-醇 (3R,4S)-4-(2-Hydroxy-Ethyl)-5-Methoxy-Tetrahydro-Furan-3-Ol 501921-32-0
((3S,4R)-4-Hydroxy-2-Methoxy-Tetrahydro-Furan-3-yl)-Acetaldehyde 1026365-72-9
(2S,53)-3-(1,3-Dioxolan-2-yl)Pentane-1,2,5-Triol 681463-04-7 Hexahydrofuro[2,3-B]Furan-3-Yl Acetate 640289-34-5 (3S*,4'R*)-3-(2',2'-Dimethyl-[1',3']Dioxolane-4'-yl)Tetrahydrofuran-2-Ol

α-乙酰基-γ-丁内酯置于aluminum (III) Chloride,Lithium Aluminium Tetrahydride,硫酸,溴,三乙胺体系中,用 四氢呋喃,Aq. Phosphate Buffer,二氯甲烷,水,二甲基亚砜 用作溶剂,化学反应 12.0H,反应生成(3R,3As,6Ar)-六氢呋喃并[2,3-B]呋喃-3-醇
参考文献:Method For Preparing Hexahydrofuro-Furanol Derivative,Intermediate Thereof And Preparation Method Thereof
标题:Method For Preparing Hexahydrofuro-Furanol Derivative,Intermediate Thereof And Preparation Method Thereof
摘要:本发明涉及制药合成领域,特别涉及六氢呋喃-呋喃醇衍生物的制备方法,其中间体及其制备方法.该制备方法包括卤代反应,酰化反应,酶催化还原反应,与胺化合物反应,还原环闭合反应(a1,A2,B,Cp1,Cl,Cf),其中,R1,R2,R3为氢或羟基保护基;R4和r5相同或不同,为苯基,烷基或取代苯基.在六氢呋喃-呋喃醇衍生物的制备过程中,手性是通过酶催化方法构建的,采用这种技术手段可以制备出光学纯度非常高的产品.该制备方法可用于在商业生产中制备达芦那韦的关键中间体(3R,3As,6Ar)-六氢呋喃[2,3-B]-3-醇,这是一种非常经济适用于工业生产的路线.

专利信息

专利号:WO-2009030733-A1
优先权日:2007-09-04
标 题 :Method for the synthesis of 4-alkoxy-, 4-hydroxy- and 4-aryloxy-substituted tetrahydro-furo[3,4-b]furan-2(3h)-one compounds
发明人：QUAEDFLIEG PETER JAN LEONARD MARIO; ALSTERS PAULUS LAMBERTUS; STRAATMAN HENRICUS MARTINUS MARIO; HANBAUER MARTIN HELMUT FRIEDRICK
权利人:DSM IP ASSETS BV; QUAEDFLIEG PETER JAN LEONARD MARIO; ALSTERS PAULUS LAMBERTUS; STRAATMAN HENRICUS MARTINUS MARIA GERARDUS; HANBAUER MARTIN HELMUT FRIEDRI
摘要:The present invention relates to a method for the synthesis of enantiomerically and diastereomerically enriched 4-alkoxy-, 4-hydroxy- or 4-aryloxy- substituted tetrahydro-furo[3,4-b]furan-2(3H)-ones by aldol coupling of a suitable hydroxyl-protected hydroxy-acetaldehyde and 4-oxobutanoic acid or an ester thereof, and subsequent removal of the protecting group from the aldol compound and (optionally simultaneous) cyclizations and acetal formation under acidic conditions in the presence of an alcohol, followed by optional isolation of the desired compounds. The invention also relates to compounds according to formulae [Xl] and [XII].

专利号:US-8431745-B2
优先权日:2006-03-29
标题 :Process for preparation of HIV protease inhibitors
发明人：CRAWFORD KENNETH R; DOWDY ERIC D; GUTIERREZ ARNOLD; POLNIASZEK RICHARD P; YU RICHARD HUNG CHIU
权利人:CRAWFORD KENNETH R; DOWDY ERIC D; GUTIERREZ ARNOLD; POLNIASZEK RICHARD P; YU RICHARD HUNG CHIU; GILEAD SCIENCES INC
摘要:A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed.

专利号:US-2010184989-A1
优先权日:2007-03-12
标 题 :De Novo Synthesis of Conjugates
发明人：RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J
权利人:NEKTAR THERAPEUTICS
摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.

专利号:AU-2008226820-A1
优先权日:2007-03-12
标题 :De novo synthesis of conjugates

专利号:CA-2679473-A1
优先权日:2007-03-12
标题:De novo synthesis of conjugates

专利号:US-2010168422-A1
优先权日:2008-12-30
标 题:Methods and intermediates useful in the synthesis of hexahydrofuro [2,3-b]furan-3-ol
发明人：CHEN WEIPING
权利人:CHEN WEIPING
摘要:Provided herein are compounds and methods useful for preparing hexahydrofuro[2,3-b]furan-3-ol. Hexahydrofuro[2,3-b]furan-3-ol can be efficiently synthesized in four steps from readily available starting materials.