CAS: 156130-68-6; (R)-2-((Tert-Butoxycarbonyl)Amino)-5-Phenylpentanoic Acid

该化合物是一种化学化合物,是一种受保护的氨酸形式,专门设计用于浸泡物合成和研究."乙氧基碳酸酯"组是氨胺的常见保护群体,允许有选择地作出反应,而不会干扰氨基功能.该组的化合物特征是苯基组,该组有助于其疏水特性,并能够影响化合物在生物系统中的相互作用.DCHA(二氯乙酸)盐形式增强了各种溶剂的溶性,使其更容易用于实验室应用.该化合物通常用于聚氨基酸和其他生物活性分子的合成中,而氨基氨基酸和其他生物活性分子的保护对于控制反应途径至关重要.其结构特征,包括存在水利和水利恐惧区,使它成为有机和药用化学的多用途建筑块.和许多氨基酸衍生物一样,必须谨慎处理这一化合物,并遵循适当的安全规程.

英文名称(R)-2-((Tert-Butoxycarbonyl)Amino)-5-Phenylpentanoic Acid
中文名称(R)-2-((叔丁氧基羰基)氨基)-5-苯基戊酸
其它别名(R)-2-叔丁氧羰基氨基-5-苯戊酸; Boc-D-Nva(5-Phenyl)-Oh Dcha
CAS编号156130-68-6
MFCD编号:MFCD11977244
分子式:C16H23NO4分子量:293.36
产品CID: 776508
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: AIFKBFKJMQTYAM-CYBMUJFWSA-N
1S/C16H23NO4/c1-16(2,3)21-15(20)17-13(14(18)19)11-7-10-12-8-5-4-6-9-12/h4-6,8-9,13H,7,10-11H2,1-3H3,(H,17,20)(H,18,19)/t13-/m1/s1
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数6.0

相似化合物

959578-11-1 1217731-48-0 62777-25-7

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

上下游产品

CAS号637-59-2 1-溴-3-苯基丙烷 | CAS号108019-30-3 DL-N-acetyl-2-a... | CAS号52161-73-6 diethyl 2-aceta...

合成工艺路线路线简述

合成目标产物 Boc-D-2-Amino-5-Phenyl-Pentanoic Acid Dcha Salt 主要起始原料 Benzenepentanoic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Ethyl Ester, (αr)-
(文献来源)合成步骤主要原料 Benzenepentanoic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Ethyl Ester, (αr)-

📜D-N-Acetyl-2-Amino-5-Phenylpentanoic Acid置于盐酸,Sodium Hydroxide,三乙胺体系中,用四氢呋喃,乙醇用作溶剂,化学反应 45.0H,反应生成(αr)-α-[[(1,1-二甲基乙氧基)羰基]氨基]-苯戊酸
参考文献:Structure Activity Studies Of The Serine-Aib Dipeptide Domain In 2,3-Dihydroisothiazole Based Growth Hormone Secretagogues
标题:Structure Activity Studies Of The Serine-Aib Dipeptide Domain In 2,3-Dihydroisothiazole Based Growth Hormone Secretagogues
摘要:A Series Of Growth Hormone Secretagogues (Ghss) Based On 2,3-Dihydroisothiazole Has Been Synthesized In The Search For A Potential Treatment Of Growth Hormone Deficiency Or Frailty In The Elderly. This Paper Describes The Evaluation Of The Sar Of The Benzyl-D-Ser-Aminoisobutyric Acid Dipeptide Fragment. Introduction Of Substituents In The Peptide Backbone And In The Phenyl Ring Has Been Investigated,As Well As Replacements For The Benzyl Group And For The Aib Residue. A Number Of Modifications Resulted In Enhanced Potency Over The Parent Benzyl-D-Ser-Aib Derivative. (C) 2005 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2005.07.070

海关参考信息

2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2006167268-A1
优先权日:2002-04-09
标题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA M; TEBBE MARK J
权利人:ELI LILLY AND COMPANY PATENT D
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-7396846-B2
优先权日:2002-04-09
标题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA MARIA; TEBBE MARK JOSEPH
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.