CAS: 154235-83-3; Piperidin-1-Yl(Quinoxalin-6-yl)Methanone

上下游产品

6-喹喔啉羧酸 Quinoxaline-6-Carboxylic Acid 6925-00-4

📜6-喹喔啉羧酸 反应生成安帕来斯
参考文献: Drugs That Enhance Synaptic Responses Mediated By Ampa Receptors[fr] Medicaments Ameliorant Les Reponses Synaptiques Induites Par Les Recepteurs Ampa
标题: Drugs That Enhance Synaptic Responses Mediated By Ampa Receptors[fr] Medicaments Ameliorant Les Reponses Synaptiques Induites Par Les Recepteurs Ampa
摘要:(En) 披露了用于增强由ampa受体介导的突触反应的化合物,以及其制备方法和用于治疗因兴奋性突触数量或ampa受体数量不足而导致神经或智力功能受损的患者的方法.该发明化合物还可用于治疗非受损主体,以增强依赖于利用ampa受体的脑网络的感觉运动和认知任务的表现,并改善记忆编码. (Fr) 披露了用于增强由ampa受体介导的突触反应的化合物,以及其制备方法和用于治疗因兴奋性突触数量或ampa受体数量不足而导致神经或智力功能受损的患者的方法.该发明化合物还可用于治疗非受损主体,以增强依赖于利用ampa受体的脑网络的感觉运动和认知任务的表现,并改善记忆编码.

专利信息

专利号:WO-2024020091-A1
优先权日:2022-07-19
标 题 :Inhibitors of short-chain dehydrogenase activity for reducing glial fibrillary acidic protein levels
发明人：MARKOWITZ SANFORD; PIEPER ANDREW
权利人:UNIV CASE WESTERN RESERVE; THE US GOV AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS
摘要:A method of decreasing blood glial fibrillary acidic protein (GFAP) levels in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor. Astroglia cells are the major and perhaps most abundant cell types in the brain. In healthy brain, astrocytes help with providing structural and network support for neurons and interface with the brain vasculature, including the blood-brain-barrier. Functionally, astrocytes are involved with providing neurotrophic factors (such as glial derived neurotrophic factor (GDNF)), and cytokine/chemokine release that influences the global and local inflammatory response environments, as well as working closely with neurons involved in the glutamate-glutamine synthesis/recycling pathway.