CAS: 1517-05-1; Azido-Peg1

相似化合物

113738-22-0 18523-48-3 24345-74-2

上下游产品

CAS号195384-42-0 N-[(2S,3R,4R,5R... | CAS号18523-48-3 叠氮乙酸 | CAS号20237-92-7 2-(4,5-二氢恶唑-2-基)苯酚 | CAS号88150-46-3 3-O-ethyl 5-O-m... | CAS号88150-45-2 ETHYL (2-AZIDOE... | CAS号74731-63-8 2-(1H-1,2,3-三唑-... | CAS号7127-19-7 2-苯基-2-恶唑啉 | CAS号74862-19-4 2-(2-azidoethox... | CAS号15791-08-9 2,6-dichloro-1H... | CAS号3445-12-3 1-(2-hydroxyeth...

C.I.酸性橙108置于盐酸,Sodium Nitrite,Sodium Azide体系中,用 水,乙酸乙酯 用作溶剂,化学反应生成2-叠氮基乙醇
参考文献:金属结合药效团点击衍生的新型广谱金属-β-内酰胺酶抑制剂的发现
标题:金属结合药效团点击衍生的新型广谱金属-β-内酰胺酶抑制剂的发现
摘要:金属-β-内酰胺酶(mbl)的出现赋予了对几乎所有β-内酰胺抗生素(包括碳青霉烯类)的耐药性.目前,缺乏临床上有用的 Mbl 抑制剂,因此发现能够有效靶向多种临床相关 Mbl 的新抑制剂化学型至关重要.在此,我们报告了一种利用金属结合药效团 (Mbp) 点击方法来识别新的广谱 Mbl 抑制剂的策略.我们的初步研究确定了几种 Mbp,包括邻苯二甲酸,苯基硼酸和苄基磷酸,它们使用叠氮-炔点击反应进行结构转变.随后的结构-活性关系分析导致了几种有效的广谱 Mbl 抑制剂的鉴定,包括针对多种 Mbl 的 Ic 值范围为 0.00012 μm 至 0.64 μm.共晶研究证明了 Mbp 在与 Mbl 活性位点锚定药效团特征结合方面的重要性,并揭示了与 Imp-1 不寻常的两分子结合模式,强调了灵活的活性位点环在识别结构多样的底物/抑制剂中的关键作用.我们的工作为 Mbl 抑制提供了新的化学型,并为针对
Doi:10.1016/j.Ejmech.2023.115473

专利信息

专利号:US-8461298-B2
优先权日:2004-11-01
标 题:Compositions and methods for modification of biomolecules
发明人：BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL
权利人:BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL; UNIV CALIFORNIA
摘要:The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

专利号:US-8669335-B2
优先权日:2010-02-15
标 题 :Knotty polymers via supramolecularly templated macroinitiators and living polymerization and methods for making and using same
发明人：ADVINCULA RIGOBERTO
权利人:ADVINCULA RIGOBERTO; UNIV HOUSTON SYSTEM
摘要:A design, synthesis and use of templated chemical routes are disclosed for the synthesis of interlocked macromolecular structures and orderly entanglements that are dubbed “Knotty Polymersâ€? using combined supramolecularly assembled macroinitiators and living polymerization.

专利号:WO-9925689-A1
优先权日:1997-11-14
标题 :Process for the preparation of acetal derivatives of 1,4-dihydropyridines
发明人：KARUP GUNNAR LEO; PREIKSCHAT HERBERT FRITZ; PEDERSEN SOEREN BOLS
权利人:GEA FARMACEUTISK FABRIK AS; KARUP GUNNAR LEO; PREIKSCHAT HERBERT FRITZ; PEDERSEN SOEREN BOLS
摘要:A process for the preparation of 1,4-dihydropyridine acetal derivatives of formula (II) wherein R1 each, independently, represents H, Cl or CF¿3; R?2 represents H, C¿1?-C5 alkyl, C3-C6 cycloalkyl or aralkyl; R?3 and R4¿ which may be the same or different, represent C¿1?-C5 alkyl, C3-C6 cycloalkyl, aralkyl or together represent -(CH2)m-, wherein m is 2 or 3, and n is 1 or 2, wherein the 1,4-dihydropyridine ring structure is formed by a Hantzsch synthesis carried out in one or more steps using a compound containing a group of formula (a); wherein R?3 and R4¿ have the same meanings as defined above, as one of the reactants in the Hantzsch condensation, is described. The Hantzsch synthesis, or at least one step thereof, is carried out in a solvent, which is capable of forming an azeotrope with water, under azeotropic removal of water of reaction. The compounds of formula (II) are useful as intermediates for the preparation of pharmaceutically active 1,4-dihydropyridines and other intermediates of use for such purpose.

专利号:US-9212381-B2
优先权日:2011-11-10
标 题 :Methods and compositions for labeling polypeptides
发明人：SALIC ADRIAN; LIU JING
权利人:HARVARD COLLEGE
摘要:Synthesis of many proteins is tightly controlled at the level of translation and plays an essential role in fundamental processes such as cell growth and proliferation, signaling, differentiation or death. Methods that allow imaging and identification of nascent proteins allow for dissecting regulation of translation, both spatially and temporally, including in whole organisms. Described herein are robust chemical methods for imaging and affinity-purifying nascent polypeptides in cells and in animals, based on puromycin analogs. Puromycin analogs of the present invention form covalent conjugates with nascent polypeptide chains, which are rapidly turned over by the proteasome and can be visualized and specifically captured by a bioorthogonal reaction (e.g., [3+2] cycloaddition). The methods of the present invention have broad applicability for imaging protein synthesis and for identifying proteins synthesized under various physiological and pathological conditions in vivo.

专利号:US-2015252402-A1
优先权日:2014-03-07
标 题 :Chemoenzymatic Synthesis of Trehalose Analogs

专利号:CN-101428786-A
优先权日:2008-12-08
标 题 :One-step reaction synthesis of functionalized carbon material and its preparation method