CAS: 144317-19-1; N2-((Benzyloxy)Carbonyl)-N5-(Diphenyl(P-Tolyl)Methyl)-L-Glutamine

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N-苄氧羰基-L-谷氨酰胺 Cbz-L-Gln 2650-64-8

📜N-苄氧羰基-L-谷氨酰胺,4-甲基三苯基甲醇,乙酸酐,硫酸,置于水,乙酸乙酯,Brine,Sodium Sulfate-Iii,Oil,异丙醚体系中,用 溶剂黄146 用作溶剂,化学反应 2.37H,以a Clear,Yellow Solution Results After 15 Minutes的收率获得n-[(4-甲基苯基)二苯基甲基]-N2-[(苯基甲氧基)羰基]-L-谷氨酰胺
参考文献:Amino Acid Derivatives For Peptide Synthesis
标题:Amino Acid Derivatives For Peptide Synthesis
摘要:描述了化学式i的化合物,其中n等于一或二,R.Sub.1代表氢或氨基保护基,R.Sub.2代表氢或羧基保护基,R.Sub.3代表4-甲基三苯甲基,4,4'-二甲基三苯甲基,4,4',4"-三甲基三苯甲基.此外,还描述了公式i的化合物,它们具有反应性并适用于偶联反应,并通过激活羧基来自i导出r.Sub.2 = H.上述化合物可用作合成肽的起始材料.它们比迄今使用的r.Sub.3代表氢或氨基甲酰保护基的类似化合物更为适用.

专利信息

专利号:US-5455363-A
优先权日:1991-10-11
标题 :Amino acid derivatives for peptide synthesis
发明人：GOSTELI JACQUES; SAX BEAT; DICK FRITZ; TANNER RUDOLF
摘要:Compounds of formula I are described, I wherein n is equal to one or two, R1 stands for hydrogen or an amino protecting group, R2 represents hydrogen or a carboxyl protecting group and R3 4-methyltriphenylmethyl, 4,4'-dimethyltriphenylmethyl, 4,4',4''-trimethyltriphenylmethyl. Furthermore described are compounds of formula I which are reactive and suitable for coupling reactions and are derived from I with R2=H by activation of the carboxyl group. The compounds mentioned above can be used as starting materials for the synthesis of peptides. They are more suitable than analogous compounds of formula I, wherein R3 represents hydrogen or a carbamoyl protecting group used hitherto.