CAS: 139290-70-3; Tert-Butyl 4-(Methoxy(Methyl)Carbamoyl)Piperidine-1-Carboxylate

相似化合物

215950-19-9 137076-22-3 206989-61-9

上下游产品

1-Boc-4-哌啶甲酸 N-[(Tert-Butoxy)Carbonyl]Piperidine-4-Carboxylic Acid 84358-13-4
4-[(Methoxymethylamino)Carbonyl]-1-Piperidinecarboxylic Acid
4-氯羰基-哌啶-1-羧酸叔丁酯 Tert-Butyl 4-(Chlorocarbonyl)-Piperidine-1-Carboxylate 280115-99-3
N-Boc-4-哌啶甲酸甲酯 1-Tert-Butyl 4-Methyl Piperidine-1,4-Dicarboxylate 124443-68-1
N-Boc-4-哌啶甲酸乙酯 1-Tert-Butyl 4-Ethyl Piperidine-1,4-Dicarboxylate 142851-03-4

4-哌啶甲酸置于氯化亚砜,Potassium Carbonate,三乙胺体系中,用 四氢呋喃,二氯甲烷,水 用作溶剂,化学反应 23.0H,反应生成1-Boc-4-[甲氧基(甲基)氨基甲酰]哌嗪
参考文献:三齿膦-二胺配体的铱配合物催化的对环烷基和杂环酮的高度对映选择性氢化和转移氢化.
标题:三齿膦-二胺配体的铱配合物催化的对环烷基和杂环酮的高度对映选择性氢化和转移氢化.
摘要:手性膦-二胺配体的ir配合物催化芳基-哌啶-4-基甲酮和带有芳基和仲烷基取代基且具有ee高达98%的底物与催化剂的比率最高的酮的氢化和转移氢化到4000.
Doi:10.1039/c3Cc45545A

专利信息

专利号:US-8748459-B2
优先权日:2002-03-29
标 题 :Pyridinoylpiperidines as 5-HT1F agonists
发明人：COHEN MICHAEL PHILIP; KOHLMAN DANIEL TIMOTHY; LIANG SIDNEY XI; VICTOR FRANTZ; XU YAO-CHANG; YING BAI-PING; ZACHERL DEANNA PIATT; ZHANG DEYI
权利人:COHEN MICHAEL PHILIP; KOHLMAN DANIEL TIMOTHY; LIANG SIDNEY XI; VICTOR FRANTZ; XU YAO-CHANG; YING BAI-PING; ZACHERL DEANNA PIATT; ZHANG DEYI; LILLY CO ELI
摘要:The present invention relates to compounds of formula I: n nor pharmaceutically acceptable acid addition salts thereof, where;n R 1 is C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, substituted C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkyl-C 1 -C 3 alkyl, substituted C 3 -C 7 cycloalkyl-C 1 -C 3 alkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R 2 is hydrogen, C 1 -C 3 alkyl, C 3 -C 6 cycloalkyl-C 1 -C 3 alkyl, or a group of formula II nn n n n n n n n n n n n R 3 is hydrogen or C 1 -C 3 alkyl; n R 4 is hydrogen, halo, or C 1 -C 3 alkyl; n R 5 is hydrogen or C 1 -C 3 alkyl; n R 6 is hydrogen or C 1 -C 6 alkyl; and n n is an integer from 1 to 6 inclusively. n n n n n The compounds of the present invention are useful for activating 5-HT lF receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal. The present invention also relates to a process for the synthesis of intermediates in the synthesis of compounds of Formula I.

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ•?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

专利号:CN-105777668-A
优先权日:2014-12-20
标 题:Synthesis method of medicine intermediate 1-tert-butyloxycarbonyl-4-(methoxy-methyl-carbamoyl)piperidine

专利号:PL-210019-B1
优先权日:2002-03-29
标题 :Pyridinoylpiperidine compounds, method of their preparation and use, and method of preparing intermediates for their synthesis