专利号:WO-2025044766-A1 优先权日:2023-08-31 标题:Use of silicon dioxide microspheres in synthesis of ultra-long oligonucleotide and method for synthesizing ultra-long oligonucleotide 发明人:SHI YONGYONG; ZHANG MANCANG; WANG LIBING; GAO PANPAN; FANG JUN 权利人:UNIV SHANGHAI JIAOTONG; SHANGHAI DYNEGENE TECH CO LTD 摘要:The present invention relates to the technical field of oligonucleotide synthesis. Disclosed are the use of silicon dioxide microspheres in the synthesis of an ultra-long oligonucleotide and a method for synthesizing an ultra-long oligonucleotide, wherein the silicon dioxide microspheres have a specific surface area of less than 1 m2/g, and preferably, the silicon dioxide microspheres have modification groups on the surface. The method for synthesizing an ultra-long oligonucleotide comprises: performing a coupling reaction on a nucleoside phosphoramidite synthesis unit using the silicon dioxide microspheres having modification groups on the surface as carriers under coupling reaction conditions. The prepared carriers can be used to prepare an ultra-long oligonucleotide.
专利号:US-12195343-B2 优先权日:2019-10-15 标 题 :Synthesis of janus nanomaterials 发明人:WANG WEI 权利人:SAUDI ARABIAN OIL CO 摘要:Synthesizing Janus nanoparticles including forming a lamellar phase having water layers, organic layers, and a surfactant, and reacting chemical precursors in the lamellar phase to form the Janus nanoparticles at interfaces of the water layers with the organic layers.
专利号:US-2020290879-A1 优先权日:2019-03-15 标 题 :Bulk Synthesis of Janus Nanomaterials
专利号:US-11572282-B2 优先权日:2019-10-15 标题 :Synthesis of Janus nanomaterials
专利号:CN-117229330-A 优先权日:2023-08-31 标 题:Application of silica microspheres in the synthesis of ultra-long oligonucleotides and methods of synthesizing ultra-long oligonucleotides
专利号:US-11472709-B2 优先权日:2019-03-15 标题:Bulk synthesis of Janus nanomaterials
参考文献:10.1038/ncomms11281 摘要:Han H, Zhang Y, Wang N, Samani MK, Ni Y, Mijbil ZY, Edwards M, Xiong S, Sääskilahti K, Murugesan M, Fu Y, Ye L, Sadeghi H, Bailey S, Kosevich YA, Lambert CJ, Liu J, Volz S. Functionalization mediates heat transport in graphene nanoflakes. Nature Communications. 2016 Apr 29;7(1):11281. doi: 10.1038/ncomms11281.