CAS: 87694-53-9; (S)-Tert-Butyl (1-(Methoxy(Methyl)Amino)-1-Oxo-3-Phenylpropan-2-yl)Carbamate

该化合物是属于氨基甲酸类的化学化合物,其特点是具有一种复杂的分子结构,其特征是存在一个异丁基组,氨基氨基酸衍生物,其分子结构表明药物化学的潜在应用,特别是药物与生物系统相互作用的能力,该化合物有可能在有机溶剂中表现出中度至高溶性,而其水溶性可能因存在的具体功能组而不同.此外,甲氧基甲基组和苯甲基基甲基混合物的存在可能会影响其再活性和生物活动.与许多氨基乙酸衍生体一样,该物质的分子结构还可能表现出...

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CAS号13734-34-4 B°C-L-苯丙氨酸 | CAS号1117-97-1 甲氧基甲基胺 | CAS号6638-79-5 二甲羟胺盐酸盐 | CAS号474890-08-9 1,1-dimethyleth... | CAS号543-27-1 氯甲酸异丁酯 | CAS号67729-36-6 B°C-Phe-O-COO-isoBu | CAS号133010-06-7 B°C-Phe-F | CAS号85613-64-5 (3S)-b°C-3-氨基-4... | CAS号72155-45-4 N-B°C-L-苯丙氨醛 | CAS号77119-85-8 N-B°C-D-苯丙氨醛 | CAS号72155-48-7 B°C-(3S,4S)-4-氨... | CAS号66605-57-0 N-B°C-L-苯丙氨醇 | CAS号98760-08-8 (2R,3S)-1,2-环氧-...

合成工艺路线路线简述

  • 合成目标产物 Boc-Phe-N(Och3)Ch3 主要起始原料 N-(Tert-Butoxycarbonyl)-L-Phenylalanine And N,O-Dimethylhydroxylamine Hydrochloride
  • 1117-97-1 + 13734-34-4 = 87694-53-9
    反应条件:1.1 Reagents: Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dichloromethane; 2 H,Rt
    标题:Exploration Of The Carmaphycins As Payloads In Antibody Drug Conjugate Anticancer Agents
    作者:Almaliti,Jehad; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2019 卷标:161 页码:416-432]

    1117-97-1 + 13734-34-4 = 87694-53-9
    反应条件:1.1 Reagents: Diisopropylethylamine,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dichloromethane; Rt
    标题:Assessment Of The In Vitro Effect Of Antibodies Induced By Peptido-Mimetics Derived From The Plasmodium Merozoite Surface Protein-2 In Malaria Caused By P. Berghei And P. Yoelii In Balb/c Mice
    作者:Lesmes,Liliana Patricia; Et Al
    参考文献:Revista Colombiana De Ciencias Quimico-Farmaceuticas 日期:2010 卷标:39(2) 页码:188-210]

    13734-34-4 + 6638-79-5 = 87694-53-9
    反应条件:1.1 Reagents: 1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dichloromethane; 10 Min,Rt1.2 Reagents: Triethylamine; Overnight,Rt
    标题:Probing α-Amino Aldehydes As Weakly Acidic Pronucleophiles: Direct Access To Quaternary α-Amino Aldehydes By An Enantioselective Michael Addition Catalyzed By Bronsted Bases
    作者:Garcia-Urricelqui,Ane; Et Al
    参考文献:Chemistry - A European Journal 日期:2021 卷标:27(7) 页码:2483-2492]

    24424-99-5 + 63-91-2 + 6638-79-5 = 87694-53-9
    反应条件:1.1 Reagents: Triethylamine Solvents: Methanol; 16 H,Rt1.2 Reagents: Triethylamine,1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dichloromethane; 10 Min,Rt1.3 16 H,Rt
    标题:Convenient Synthesis Of Alternatively Bridged Tryptophan Ketopiperazines And Their Activities Against Trypanosomatid Parasites
    作者:Cockram,Peter E.; Et Al
    参考文献:Chemmedchem 日期:2022 卷标:17(4)]

    51987-73-6 + 6638-79-5 = 87694-53-9
    反应条件:1.1 Reagents: Chloro(1-Methylethyl)Magnesium Solvents: Tetrahydrofuran; 15 Min,-40 °C; 3 H,-30 °C -> 0 °C1.2 Reagents: Ammonium Chloride Solvents: Water
    标题:Synthesis And Antiproteasomal Activity Of Novel O-Benzyl Salicylamide-Based Inhibitors Built From Leucine And Phenylalanine
    作者:Jorda,Radek; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2017 卷标:135 页码:142-158]

    474890-08-9 + 6638-79-5 = 87694-53-9
    反应条件:1.1 Reagents: Triethylamine Catalysts: Methanesulfonic Acid,1,1,1-Trifluoro-,Samarium(3+) Salt (3:1) Solvents: Tetrahydrofuran1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:A Convenient Method For The Conversion Of N-Acyloxazolidinones To Hydroxamic Acids
    作者:Sibi,Mukund P.; Et Al
    参考文献:Organic Letters 日期:2002 卷标:4(20) 页码:3343-3346]

    6638-79-5 + 514214-66-5 = 87694-53-9
    反应条件:1.1 Solvents: Tetrahydrofuran; 5 Min; 24 H,Rt
    标题:An Efficient Conversion Of Carboxylic Acids Into Weinreb Amides
    作者:Katritzky,Alan R.; Et Al
    参考文献:Arkivoc (Gainesville 日期:2002 卷标:(11) 页码:39-44]

    13734-34-4 = 87694-53-9 [标题:Reaction Conditions
    标题:A Facile Approach To Trans-4,5-Pyrrolidine Lactam And Application In The Synthesis Of Nemonapride And Streptopyrrolidine
    作者:Huang,Wei; Et Al
    参考文献:Tetrahedron 日期:2011 卷标:67(40) 页码:7829-7837]

    37073-15-7 + 13734-34-4 = 87694-53-9
    反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; Rt; 6 - 12 H,Reflux2.1 Solvents: Tetrahydrofuran; 5 Min; 24 H,Rt
    标题:An Efficient Conversion Of Carboxylic Acids Into Weinreb Amides
    作者:Katritzky,Alan R.; Et Al
    参考文献:Arkivoc (Gainesville 日期:2002 卷标:(11) 页码:39-44]

    163625-26-1 + 100-52-7 = 87694-53-9
    反应条件:1.1 Catalysts: Gold(1+),Bis[(Isocyano-Kc)Cyclohexane]-,Tetrafluoroborate(1-) (1:1),(1R)-1,1′-Bis(Diphenylphosphino)-2-[(1R)-1-[methyl[2-(4-Morpholinyl)Ethyl]Amino]... Solvents: Dichloromethane2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol3.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water3.2 Reagents: Ammonium Hydroxide Solvents: Water3.3 -3.4 Reagents: Triethylamine
    标题:Gold(I)-Catalyzed Asymmetric Aldol Reaction Of N-Methoxy-N-Methyl-α-Isocyanoacetamide (α-Isocyano Weinreb Amide). An Efficient Synthesis Of Optically Active β-Hydroxy α-Amino Aldehydes And Ketones
    作者:Sawamura,Masaya; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1995 卷标:60(6) 页码:1727-32]

    163625-27-2 = 87694-53-9
    反应条件:1.1 Reagents: Triethylamine,Phosphorus Oxychloride Solvents: Tetrahydrofuran1.2 Reagents: Sodium Bicarbonate Solvents: Dichloromethane,Water2.1 Catalysts: Gold(1+),Bis[(Isocyano-Kc)Cyclohexane]-,Tetrafluoroborate(1-) (1:1),(1R)-1,1′-Bis(Diphenylphosphino)-2-[(1R)-1-[methyl[2-(4-Morpholinyl)Ethyl]Amino]... Solvents: Dichloromethane3.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol4.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water4.2 Reagents: Ammonium Hydroxide Solvents: Water4.3 -4.4 Reagents: Triethylamine
    标题:Gold(I)-Catalyzed Asymmetric Aldol Reaction Of N-Methoxy-N-Methyl-α-Isocyanoacetamide (α-Isocyano Weinreb Amide). An Efficient Synthesis Of Optically Active β-Hydroxy α-Amino Aldehydes And Ketones
    作者:Sawamura,Masaya; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1995 卷标:60(6) 页码:1727-32]

    109-94-4 + 120939-75-5 = 87694-53-9
    反应条件:1.1 Solvents: Ethyl Formate2.1 Reagents: Triethylamine,Phosphorus Oxychloride Solvents: Tetrahydrofuran2.2 Reagents: Sodium Bicarbonate Solvents: Dichloromethane,Water3.1 Catalysts: Gold(1+),Bis[(Isocyano-Kc)Cyclohexane]-,Tetrafluoroborate(1-) (1:1),(1R)-1,1′-Bis(Diphenylphosphino)-2-[(1R)-1-[methyl[2-(4-Morpholinyl)Ethyl]Amino]... Solvents: Dichloromethane4.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol5.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water5.2 Reagents: Ammonium Hydroxide Solvents: Water5.3 -5.4 Reagents: Triethylamine
    标题:Gold(I)-Catalyzed Asymmetric Aldol Reaction Of N-Methoxy-N-Methyl-α-Isocyanoacetamide (α-Isocyano Weinreb Amide). An Efficient Synthesis Of Optically Active β-Hydroxy α-Amino Aldehydes And Ketones
    作者:Sawamura,Masaya; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1995 卷标:60(6) 页码:1727-32]

    13734-34-4 + 6638-79-5 = 87694-53-9
    反应条件:1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane; Rt; 1.25 H,Rt1.2 Solvents: Dichloromethane; Overnight,Rt
    标题:Heterocyclic Cathinones As Inhibitors Of Kynurenine Aminotransferase Ii-Design,Synthesis,And Evaluation
    作者:Maryska,Michal; Et Al
    参考文献:Pharmaceuticals 日期:2021 卷标:14(12)]

    1117-97-1 + 35150-06-2 = 87694-53-9
    反应条件:1.1 Solvents: Dichloromethane; 5 Min,23 °C1.2 Reagents: N-(Dimethoxymethyl)-N-(1-Methylethyl)-2-Propanamine; 23 °C -> Reflux; 4 H,Reflux; Reflux -> 23 °C1.3 3 Min,23 °C1.4 Catalysts: Zirconium Chloride (Zrcl4) Solvents: Acetonitrile; 1 H,23 °C
    标题:Efficient Transamidation Of Primary Carboxamides By In Situ Activation With N,N-Dialkylformamide Dimethyl Acetals
    作者:Dineen,Thomas A.; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2006 卷标:128(50) 页码:16406-16409]

    24424-99-5 = 87694-53-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water1.2 Reagents: Ammonium Hydroxide Solvents: Water1.3 -1.4 Reagents: Triethylamine
    标题:Gold(I)-Catalyzed Asymmetric Aldol Reaction Of N-Methoxy-N-Methyl-α-Isocyanoacetamide (α-Isocyano Weinreb Amide). An Efficient Synthesis Of Optically Active β-Hydroxy α-Amino Aldehydes And Ketones
    作者:Sawamura,Masaya; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1995 卷标:60(6) 页码:1727-32]

    24424-99-5 + 133489-47-1 = 87694-53-9 [标题:Reaction Conditions
    标题:Novel Bis-Cyclic Guanidines As Potent Membrane-Active Antibacterial Agents With Therapeutic Potential
    作者:Teng,Peng; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2017 卷标:53(87) 页码:11948-11951]

    13734-34-4 + 626-67-5 = 87694-53-9
    反应条件:1.1 Solvents: Dichloromethane
    标题:Preparation Of Heterocyclic Conformationally Restricted Hiv-1 Protease Inhibitors
    参考文献:United Kingdom]

    163625-30-7 = 87694-53-9
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol2.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water2.2 Reagents: Ammonium Hydroxide Solvents: Water2.3 -2.4 Reagents: Triethylamine
    标题:Gold(I)-Catalyzed Asymmetric Aldol Reaction Of N-Methoxy-N-Methyl-α-Isocyanoacetamide (α-Isocyano Weinreb Amide). An Efficient Synthesis Of Optically Active β-Hydroxy α-Amino Aldehydes And Ketones
    作者:Sawamura,Masaya; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1995 卷标:60(6) 页码:1727-32]

    24424-99-5 + 63-91-2 = 87694-53-9
    反应条件:1.1 Reagents: Triethylamine Solvents: Methanol; 16 H,Rt2.1 Reagents: Triethylamine,1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dichloromethane; 10 Min,Rt2.2 16 H,Rt
    标题:Convenient Synthesis Of Alternatively Bridged Tryptophan Ketopiperazines And Their Activities Against Trypanosomatid Parasites
    作者:Cockram,Peter E.; Et Al
    参考文献:Chemmedchem 日期:2022 卷标:17(4)]

    24424-99-5 + 7524-50-7 = 87694-53-9
    反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C; 20 H,0 °C -> Rt2.1 Reagents: Chloro(1-Methylethyl)Magnesium Solvents: Tetrahydrofuran; 15 Min,-40 °C; 3 H,-30 °C -> 0 °C2.2 Reagents: Ammonium Chloride Solvents: Water
    标题:Synthesis And Antiproteasomal Activity Of Novel O-Benzyl Salicylamide-Based Inhibitors Built From Leucine And Phenylalanine
    作者:Jorda,Radek; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2017 卷标:135 页码:142-158
📜Boc-L-苯丙氨酸 反应生成 Boc-Phe-甲氧基甲胺
参考文献:Crcl 2介导n保护的α-氨基醛的烯丙基化.包含羟乙烯等排异构体的多肽的多功能合成
标题:Crcl 2介导n保护的α-氨基醛的烯丙基化.包含羟乙烯等排异构体的多肽的多功能合成
摘要:不同取代的烯丙基溴与n-保护的氨基醛反应,反应生成用于合成羟乙烯二肽等排体的中间产物.使用受阻基团保护的醛可以改善该反应的低立体选择性.该反应可以有效地应用于寡肽醛.我们描述了一种用于制备含有羟乙烯等排体的肽的方案,该方案可以快速改变氨基酸序列
DOI:10.1016/s0040-4039(00)76862-6

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专利信息


专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2009275727-A1
优先权日:1998-03-24
标题:Peptide turn mimetics
发明人：CASSIDY PETER J; ALEWOOD PAUL FRANCIS; VERNALL ANDREA JOY
权利人:MIMETICA PTY LTD
摘要:This invention provides novel compounds useful for the synthesis of peptide mimetics, and describes the use of these compounds for the synthesis of novel reverse turn mimetics. The reverse turn mimetics of the invention have the general structure X wherein the variables are as defined herein.

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合成参考文献


摘要:Mahajan, Y. R.; Weinreb, S. M., Science of Synthesis, (2005) 21, 1.
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