CAS: 75677-02-0; 3-(4-Chlorophenyl)Propanal

上下游产品

4-chlor°Cinnamaldehyde 1-Chloro-4-iodobenzene allyl alcohol 4-vinylbenzyl chloride 6-(p-chlorophenyl)-trans-3-hexen-2-one [(S)-1-({(R)-1-[3-(4-Chloro-phenyl)-propyl]-pyrrolidin-3-yl}-methyl-carbamoyl)-pyrrolidin-3-yl]-methyl-carbamic acid tert-butyl ester ethyl-5-(4-chlorophenyl)pent-2-enoate (S)-3-(4-chlorophenyl)-1,2-propanediol

📜对氯肉桂酸置于lithium Aluminium Tetrahydride,Pyridinium Chlorochromate体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 5.0H,反应生成 3-(4-氯苯基)丙二醛
参考文献:2,6-二甲基吗啉新的萘苯醚酮类似物的合成及杀真菌活性的研究
标题:2,6-二甲基吗啉新的萘苯醚酮类似物的合成及杀真菌活性的研究
摘要:摘要以stellera Chamaejasme L.的天然产物1,5-二苯基-2-戊烯-1-酮(i)为前导化合物,设计合成了一系列新型的萘苯醌类似物,其中2,6-二甲基吗啉部分为引入以取代1-苯基.通过红外,1 H NMR和hrms(esi)或元素分析,某些代表性化合物的13 C NMR确认了它们的结构.通过noesy技术和化学方法分离并鉴定了目标化合物的两种异构体.已经评估了所有合成的化合物的抗植物病原性真菌活性.结果表明,某些化合物在50 Mg / L的浓度下对被测真菌表现出中等至非常好的抗真菌活性.其中,化合物7D具有4-溴取代的苯基和顺式-2,6-二甲基吗啉部分,对valsa Mali表现出最佳活性,Ec 50为23.87μmol/ L,优于铅化合物i.此外,初步的结构-活性关系分析表明,在目标化合物的两个异构体之间,该异构体对顺式-2,6-二甲基吗啉的抗真菌活性优于反式异构体.
DOI:10.1016/j.Cclet.2016.01.045

专利信息

专利号:US-4355184-A
优先权日:1980-05-02
标题:Synthesis of α, β-unsaturated-ketones
发明人：KAKU TSUTOMU; KATSUURA KIYOSHI; SAWAKI MIKIO
权利人:NIPPON SODA CO
摘要:alpha , beta -unsaturated-ketones are synthesized by reacting with an aldehyde and an alkali metal salt of acetoacetic acid in the presence of an aliphatic secondary amine in the mixture of heterogeneous solvents producing an oil layer and a water layer.

专利号:US-11390590-B2
优先权日:2016-08-16
标 题 :Methods and processes for the preparation of KDM1A inhibitors
发明人：TAPPER AMY E; CELATKA CASSANDRA; ROMERO ARTHUR GLENN; MCCALL JOHN M; CHANCELLOR TONI; CHEN JIAN-XIE; CHEN XUEMEI; ZHAO HE; BIOLATTO BETINA; BROT ELISABETH C A; LI ZHIHUA; LIAO XIAOMING
权利人:IMAGO BIOSCIENCES INC
摘要:Provided in this disclosure are methods for the synthesis of substituted 2-arylcyclopropylamines and 2-heteroarylcyclopropylamines and related compounds. Also provided are methods for reduction of thioesters to aldehydes, and methods for reductive animation of cyclopropylamines.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-6140505-A
优先权日:1995-03-10
标 题:Synthesis of benzo fused heterocyclic sulfonyl chlorides

专利号:US-4112230-A
优先权日:1975-04-11
标题 :Δ2,3 -1,4 Morpholine-2-carboxylic acid derivatives as antibacterial agents
发明人：MENARD MARCEL; LIM GARY M F; CONWAY TERRY T
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein Z is halo, hydroxyl, etherified hydroxyl or hydroxyl esterified with a carboxylic acid residue or a sulfonic acid residue and X is amino, azido or acylamino. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

专利号:US-4118566-A
优先权日:1975-07-23
标 题:Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents
发明人：HORNING DONALD E; MORRIS LEESON R; DOUGLAS JAMES L
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is amino, azido or acylamido and Z represents optionally substituted C1-C6 alkyl, aryl, aralkyl or heterocyclic. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.