CAS: 6159-55-3; (S)-1,2,3,9-Tetrahydropyrrolo[2,1-B]Quinazolin-3-Ol
该化合物是双环结构,包括一个quinazoline框架. (-)-瓦西辛展示了一系列生物活动,包括抗炎,抗菌和支气管活性,使其对医药化学和药理感兴趣.它通常以白到白晶粉的形式出现,在乙醇和乙醇等有机溶剂中溶解,但水中溶解程度较低.该化合物的立体化学作用很重要,因为(-)指定表明其特定的光学活动,可能影响其生物相互作用.对(-)-瓦西丁的研究继续探索其潜在的治疗应用,特别是在呼吸道条件下.然而,正如许多天然产品一样,必须进一步研究,以充分了解其在临床环境中的行动和功效机制.
- 英文名称(S)-1,2,3,9-Tetrahydropyrrolo[2,1-B]Quinazolin-3-Ol
- 中文名称骆驼蓬碱
- IUPAC名称(S)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol
- 其它别名Peganine; (-)-Linarine; L-Vasacine; (3S)-1H,2H,3H,9H-Pyrrolo[2,1-B]Quinazolin-3-Ol; 4-Amino-3-Chlorobenzenesulfonylfluoride; (-)-Peganine; (-)-Vasicine; L-Peganine; (3S)-1,2
- CAS编号6159-55-3
- MFCD编号:MFCD09028068
- EINECS号:228-180-8
- FDA UNII编号:6C2ZBI733P
- 分子式:C11H12N2O分子量:188.23
- 产品CID: 2491576
- 产品分类生物化工 → 中草药成分
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号6159-56-4 (±)-Vasicine | CAS号101385-90-4 (S)-3-羟基-1-苄基吡咯烷 | CAS号486-64-6 鸭嘴花酮碱 | CAS号495-59-0 化合物DESOXYPEGANINE | CAS号55727-59-8 2-吡咯烷-1-甲基苯胺合成工艺路线路线简述
📜(+/-)-鸭咀花碱置于d-酒石酸体系中,化学反应生成 骆驼蓬碱
参考文献:Spaeth; Hicks; Zajic,Chemische Berichte,1935,Vol. 68,P. 1389
标题:Spaeth; Hicks; Zajic,Chemische Berichte,1935,Vol. 68,P. 1389
海关参考信息
- 2902300000-甲苯
2905122000-异丙醇
2922110001-单乙醇胺
2922192100-二甲氨基乙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:BR-PI1003128-A2
优先权日:2010-08-06
标题 :synthesis process of meta and para-4-arylaminoquinazole compounds for inhibition of epidermal growth factor tyrosine kinase activity (egfrk)
专利号:CN-118772160-B
优先权日:2024-07-12
标题 :Trifluoromethyl group is a dihydropyrrolo of (2) quinazolinone compound and synthesis method thereof
专利号:CN-114108013-B
优先权日:2021-12-31
标 题 :An electrochemical synthesis method of trifluoromethyl-substituted polycyclic quinazolinone derivatives
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Wang N, Liu Y, Yang C, Du J, Yu D, He P, Xu H, Li L, Zhao P, Li Y. Molecular insights into vasicine and butyrylcholinesterase interactions: A complimentary biophysical, multi-spectroscopic, and computational study. Int J Biol Macromol. 2024 Dec 27;292:139253. doi: 10.1016/j.ijbiomac.2024.139253. Epub ahead of print. 358(1):e2400742. doi: 10.1002/ardp.202400742. 10(21):e40009. doi: 10.1016/j.heliyon.2024.e40009.
5: Sun Y, Zhu D, Kong L, Du W, Qu L, Yang Y, Rao G, Huang F, Tong X. Vasicine attenuates atherosclerosis via lipid regulation, inflammation inhibition, and autophagy activation in ApoE-/- mice. Int Immunopharmacol. 2024 Dec 5;142(Pt A):112996. doi: 10.1016/j.intimp.2024.112996. Epub 2024 Sep 6.
331:118345. doi: 10.1016/j.jep.2024.118345. Epub 2024 May 14. 10(4):e25727. doi: 10.1016/j.heliyon.2024.e25727.
合成参考文献
摘要:Indian Journal of Medical Research., 66(680), 1977
参考文献:10.1080/14786410500247418
摘要:Shevyakov SV, Davydova OI, Pershin DG, Krasavin M, Kravchenko DV, Kiselyov A, Tkachenko SE, Ivachtchenko AV. Natural products as templates for bioactive compound libraries: synthesis of biaryl derivatives of (+/-)-vasicine. Nat Prod Res. 2006 Jul 10;20(8):735–41. doi: 10.1080/14786410500247418.
参考文献:10.1080/14786410500480993
摘要:Shevyakov SV, Davydova OI, Kiselyov AS, Kravchenko DV, Ivachtchenko AV, Krasavin M. Natural products as templates for bioactive compound libraries: part 2. Novel modifications of vasicine (peganine) core via efficient and regioselective generation of 3-lithiodeoxyvasicine and its stereoselective addition to aliphatic ketones section sign. Nat Prod Res. 2006 Jul 20;20(9):871–81. doi: 10.1080/14786410500480993.
参考文献:10.4268/cjcmm20121929
摘要:Wen FF, Zheng LM, Li XJ, Li Y, Zhang L, Cheng XM, Wang CH, Wang ZT. [Research on quality standards of herbs of Peganum harmala]. Zhongguo Zhong Yao Za Zhi. 2012 Oct;37(19):2971–6.
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