CAS: 613-46-7; 2-Naphthonitrile

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66-99-9 93-09-4 2243-82-5

上下游产品

CAS号1592-38-7 2-萘甲醇 | CAS号580-13-2 2-溴萘 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号3007-91-8 2-萘甲酸乙酯 | CAS号66-99-9 2-萘甲醛 | CAS号164269-42-5 2-(azidomethyl)... | CAS号13577-85-0 N,N-dimethylnap... | CAS号113443-62-2 N-甲氧基-N-甲基萘-2-甲酰胺 | CAS号2243-82-5 2-萘酰胺 | CAS号107574-57-2 2-methyl-1-naph... | CAS号91-20-3 萘 | CAS号7664-41-7 氨 | CAS号74-89-5 氨基甲烷 | CAS号91-57-6 2-甲基萘 | CAS号110876-52-3 2-甲基-1,2'-二萘酮 | CAS号14625-56-0 2-naphthalen-2-... | CAS号18052-85-2 2-(TRIMETHYLSIL... | CAS号20209-31-8 1,2-dihydronaph...

N,N-二甲基-2-萘甲酰胺置于二异丁基氢化铝,氨,碘体系中,用 四氢呋喃,正己烷,水 作为反应溶剂,化学反应 1.5H,以90%的收率获得产物2-萘甲腈
参考文献:N,N-二取代酰胺和异丙基酯直接转化为腈
标题:N,N-二取代酰胺和异丙基酯直接转化为腈
摘要:通过用氢化二异丁基铝处理,然后用氨水中的分子碘处理,可以将各种n,N-二甲基酰胺,N-甲氧基-N-甲基酰胺和异丙基酯以非常好至中等的收率平稳地转化为相应的腈.本反应是新颖的一锅法和实用方法,其通过分别形成半胱氨酸o-Albu 2和半缩醛o-Albu 2来将n,N-二取代酰胺和异丙酯转化为腈.
DOI:10.1016/j.Tet.2011.04.008

专利信息

专利号:US-8293946-B2
优先权日:2006-06-05
标题 :Dialdehyde compound, preparation method thereof, and synthetic method of carotenoids using the same
发明人：KOO SANG HO; CHOI EUN HO; SUH JOO-WON
权利人:KOO SANG HO; CHOI EUN HO; SUH JOO-WON; MYONGJI UNIV IND & ACAD COOP
摘要:The novel C dialdehyde compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the expeditious and practical synthetic processes for lycopene and β-carotene by the use of the above novel compound are disclosed. The syntheses of lycopene and β-carotene are characterized by the processes of the coupling reaction between two equivalents of geranyl sulfone or cyclic geranyl sulfone and the above C dialdehyde, the functional group transformation reactions of the diol in the resulting C 40 coupling products to X's (either halogens or ethers), and the double elimination reactions of the functional groups of the benzenesulfonyl and X to produce the fully conjugated polyene chain of the carotenoids.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5817827-A
优先权日:1995-11-21
标题:Method for the dehydration of amides to nitriles
发明人：BONRATH WERNER; PAULING HORST
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to a process for the dehydration of amides to nitrites which comprises carrying out the dehydration in the presence of an adduct of sulphur trioxide and an amine as the dehydrating reagent in a basic reaction mixture. Thereby, for example, aliphatic, aromatic and heteroaromatic amides are dehydrated to the corresponding nitrites, such as 5-carbamoyl-4-methyl-oxazole to 5-cyano-4-methyl-oxazole, a valuable intermediate in the synthesis of pyridoxine.

专利号:US-3879460-A
优先权日:1973-05-08
标题:Synthesis of mono-di-, and tri-substituted amidines
发明人：FUKS ROBERT
权利人:UNION CARBIDE CORP
摘要:N-substituted amidines are synthesized by the novel process comprising successively contacting with a nitrile compound (a) a Lewis acid catalyst, (b) an alkyl halide and (c) an amine. The Nsubstituted amidines produced are strong bases and thus useful for a wide variety of applications.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-5916899-A
优先权日:1996-10-18
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.