CAS: 4837-38-1; Cyclohexanesulfonyl Chloride

相似化合物

1262409-43-7 4352-30-1 384-20-3

上下游产品

cyclohexane 1,2-dicyclohexyl disulfide thi°Cyanat°Cyclohexane S-cyclohexyl ethanethioateN,N-dimethyl-cyclohexanesulfonamideN,N-dimethyl-cyclohexanesulfonamide N-phenylcyclohexanesulfonamide cyclohexanesulfonic acid methylamide 1,4-bis-cyclohexanesulfonyloxy-butane

📜Cyclohexanesulfonic Acid置于六氯环三磷腈,Potassium Chloride体系中,化学反应 0.03H,以94%的收率获得产物环己烷磺酰氯
参考文献:Tapc 促进从磺酸合成磺酰氯
标题:Tapc 促进从磺酸合成磺酰氯
摘要:描述了一种使用 Tapc 作为氯化剂从磺酸制备磺酰氯的新方法.温和的反应条件,更短的反应时间,高效率,成本效益和所需产物的容易分离使本方法成为一种实用的替代方法,并将为各种药物应用提供有价值的合成工具.
DOI:10.1055/s-0031-1289547

专利信息

专利号:US-6639059-B1
优先权日:1999-03-24
标 题 :Synthesis of [2.2.1]bicyclo nucleosides
发明人：KOCHKINE ALEXEI; FENSHOLDT JEF; PFUNDHELLER HENRIK M
权利人:EXIQON AS
摘要:A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs.

专利号:US-6734291-B2
优先权日:1999-03-24
标题:Synthesis of [2.2.1]bicyclo nucleosides
发明人：KOCHKINE ALEXEI; FENSHOLDT JEF; PFUNDHELLER HENRIK M
权利人:EXIQON AS
摘要:A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. From compounds of the general formula II, such as 3-O-aryl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-ribofuranose, intermediates of the general formula III are suitable for coupling with silylated nucleobases. Upon one-pot base-induced ring-closure and desulfonation of the formed [2.2.1]bicyclo nucleoside, a short route to each the LNA (Locked Nucleic Acid) derivatives of adenosine, cytosine, uridine, thymidine and guanidine is demonstrated. The use of the 5'-sulfonated ring-closed intermediate also allows for synthesis of 5'-amino- and thio-LNAs

专利号:US-2010204463-A1
优先权日:2007-08-07
标题 :Preparation Of Synthetic Nucleosides via Pi-Allyl Transition Metal Complex Formation
发明人：LIOTTA DENNIS C; LI YONGFENG
权利人:LIOTTA DENNIS C; LI YONGFENG
摘要:This invention provides highly regioselective and stereoselective processes for preparing synthetic nucleosides. A process for the preparation of synthetic nucleosides is provided that comprises a) preparing a bicycloamide derivative, b) reacting the bicycloamide derivative with a nucleic acid base or heterocyclic base or salt thereof in the presence of a transition metal catalyst to form a cyclopentenecarboxamide, and c) cleaving a carboxamide group from the cyclopentenecarboxamide to form the synthetic nucleoside. The processes according to the invention can be used for the synthesis of a variety of anti-viral agents, including Abacavir, Carbovir, and Entecavir, as well as derivatives thereof.

专利号:US-6479668-B1
优先权日:1998-09-08
标 题 :Method of producing pyrrolidine derivatives
发明人：MURAOKA HIDEO; SATO HARUYO
权利人:TORAY INDUSTRIES
摘要:A method for producing pyrrolidine derivatives such as 3,4-epoxypyrrolodines, 3-pyrrolidols and the like, by oxidizing 3-pyrrolines with at least one peroxide in the presence of at least one acid is disclosed. The 3-pyrrolines are produced by deriving cis-2-butene compounds from cis-2-butene-1,4-diols and performing a cyclization between the cis-2-butene derivatives and at least one primary amine. The method may be performed as a one-pot synthesis and may be performed as a continuous reaction.

专利号:US-2022315528-A1
优先权日:2019-08-21
标题:Inhibitors of phospholipid synthesis and methods of use
发明人：GOUW ARVIN; SCHOW STEVEN R; GREENHOUSE ROBERT J; KLINE TONI; FELSHER DEAN W
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome, hyperlipidemia, infection and inflammation.

专利号:US-2003092905-A1
优先权日:1999-03-24
标 题:Synthesis of [2.2.1]bicyclo nucleosides