CAS: 4532-25-6; 7-Chloroimidazo[1,2-A]Pyridine

相似化合物

6188-25-6 1195251-29-6 274-76-0

4-氯吡啶-2-羧酸叔丁酯置于盐酸,碳酸氢钠体系中,用 1,4-二氧六环,乙醇,水 作为反应溶剂,化学反应 38.0H,反应生成 7-氯咪唑并[1,2-A]吡啶
参考文献:Discovery And Optimization Of Potent Broad-Spectrum Arenavirus Inhibitors Derived From Benzimidazole And Related Heterocycles
标题:Discovery And Optimization Of Potent Broad-Spectrum Arenavirus Inhibitors Derived From Benzimidazole And Related Heterocycles
摘要:A Series Of Potent Arenavirus Inhibitors Sharing A Benzimidazole Core Were Previously Reported By Our Group. Sar Studies Were Expanded Beyond The Previous Analysis,Which Involved The Attached Phenyl Rings And Methylamino Linker Portion,To Include Modifications Focused On The Benzimidazole Core. These Changes Included The Introduction Of Various Substituents To The Bicyclic Benzimidazole Ring System Along With Alternate Core Heterocycles. Many Of The Analogs Containing Alternate Nitrogen-Based Bicyclic Ring Systems Were Found To Retain Antiviral Potency Compared To The Benzimidazole Series From Which We Derived Our Lead Compound,St-193. In Fact,21H,Built On An Imidazopyridine Core,Possessed A Near Tenfold Increase In Potency Against Lassa Virus Pseudotypes Compared To St-193. As Found With The Benzimidazole Series,Broad-Spectrum Arenavirus Activity Was Also Observed For A Number Of The Analogs Discovered During This Study. (C) 2012 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2012.11.093

专利信息

专利号:US-4141898-A
优先权日:1976-08-06
标题:Imidazo pyridinium quaternary salts as hypoglycemic agents
发明人：KUHLA DONALD E
权利人:PFIZER
摘要:The synthesis of imidazo[1,2-a]pyridinium, imidazo[1,5-a]pyridinium, pyrrolo[1,2-a]pyrazinium, pyrazolo[1,5-a]pyridinium, imidazo[2,1-a]isoquinolinium and imidazo[5,1-a]isoquinolinium quaternary salts and their use as hypoglycemic agents.

专利号:US-4044015-A
优先权日:1975-09-03
标题:Imidazopyridinium compounds as hypoglycemic agents
发明人：KUHLA DONALD E
权利人:PFIZER
摘要:The synthesis of imidazo[1,2-a]pyridinium, imidazo[1,5-a]pyridinium, pyrrolo[1,2-a]pyrazinium, pyrazolo[1,5-a]pyridinium, imidazo[2,1-a]isoquinolinium and imidazo[5,1-a]isoquinolinium quaternary salts and their use as hypoglycemic agents.

专利号:US-4163745-A
优先权日:1975-09-03
标 题:Imidazo[1,5-a]-quinolinium and imidazo[1,5-a]-pyridinium compounds
发明人：KUHLA DONALD E
权利人:PFIZER
摘要:The synthesis of imidazo[1,2-a]pyridinium, imidazo[1,5-a]pyridinium, pyrrolo[1,2-a]pyrazinium, pyrazolo[1,5-a]pyridinium, imidazo[2,1-a]isoquinolinium and imidazo[5,1-a]isoquinolinium quaternary salts and their use as hypoglycemic agents.

专利号:CN-112409354-A
优先权日:2020-12-23
标题:A kind of synthesis technique of 7-fluoroimidazo[1,2-A]pyridine and its intermediate

专利号:CN-112409354-B
优先权日:2020-12-23
标题:Synthesis process of 7-fluoroimidazo [1,2-A ] pyridine and intermediate thereof

专利号:CN-112851677-A
优先权日:2019-11-26
标题:Synthesis method of imidazopyridine or pyrimidine derivative