专利号:EP-0608779-A1 优先权日:1993-01-23 标题 :Apparatus for peptide synthesis 发明人:NOKIHARA KIYOSHI C O SHIMADZU 权利人:SHIMADZU CORP 摘要:An apparatus for peptide synthesis of the present invention has a means of repeating a series of treatments consisting of washing, coupling, washing and deprotecting in a stream of an inert gas; a needle for injection /aspiration of reagents; and a microtiter plate with wells of which inner wall has a linker or a microtiter plate having a membrane filter, which has a linker, placed in its wells. The peptide synthesizer allows easy washing of the solid support with only a small amount of solvent. It also makes it possible to get the synthesized product as a peptide (or DNA) solution directly from the reaction vessel by sequentially performing cleavage in the reaction vessel (in situ cleavage) after the completion of peptide chain-assembly.
专利号:EP-1105359-B1 优先权日:1998-08-21 标 题:Solid phase synthesis of compounds by carbon-carbon bond forming mitsunobu reactions 发明人:CHATURVEDI SURENDRAKUMAR 权利人:PE CORP NY 摘要:Processes are provided for the Mitsunobu alkylation reaction of carbon-carbon bond formation between a solid support reagent and a reagent in solution. The resulting novel products can be prepared as a combinatorial library by high-throughput, parallel synthesis under robotic automation. Cleaved or support-bound products are useful precursors to biologically active compounds.
专利号:US-2018150597-A1 优先权日:2016-11-29 标题 :Method for optimal design of polynucleotides sequences for analysis of specific events in any genetic region of interest 发明人:BERTHOUMIEUX SARA; FOURNE YANNICK; KOMATSU JUN; FER FREDERIC; BENSIMON AARON 权利人:GENOMIC VISION SA 摘要:Methods including in-silico steps for design and synthesis of Genomic Morse Code (“GMCâ€?) probes including design of combinations of polynucleotide sequences and labelling colors for analysis of large rearrangements in targeted genetic regions as well as allele characterization of complex regions and localization of events such as replication, DNA reparation or epigenetics in particular regions. Color-encoded sets of probes that produce characteristic or unique color patterns when painted on a target nucleic acid sequence. Methods for using color-encoded sets of probes.
专利号:US-9382288-B2 优先权日:2010-10-06 标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action 发明人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO 权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG 摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).
专利号:US-7176282-B1 优先权日:1996-09-09 标 题 :Solid-phase peptide synthesis and agent for use in such synthesis 发明人:HOLM ARNE; LARSEN BJARNE DUE 权利人:ZEALAND PHARMA AS 摘要:The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents, which are useful in solid-phase peptide synthesis.
专利号:US-7348404-B2 优先权日:1996-09-09 标题 :Solid-phase peptide synthesis and agent for use in such synthesis 发明人:HOLM ARNE; LARSEN BJARNE DUE 权利人:ZEALAND PHARMA AS 摘要:The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents which are useful in solid-phase peptide synthesis.
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