CAS: 397864-44-7; Fluticasone Furoate

该化合物是一种具有抗炎特性的合成花生类固醇,主要用于治疗哮喘和过敏鼻炎等呼吸状况,其特点是对甘蓝菌受体的高度亲近性,这提高了其在减少炎情和免疫反应方面的功效;该物质通常通过吸入或鼻喷剂施用,允许有针对性地投送到呼吸系统;Floticasonoone wooate表现出长期的行动,它支持了一次的日常施用;其化学结构包括一个氟化类固醇骨,有助于其威力和稳定性;该化合物一般具有良好的燃烧作用,其副作用可能包括局部刺激,或者在罕见的情况下,与使用花生类人有关的系统效应;作为氟虫酮家族的成员,它通常在功效和安全方面与其他花生类固醇相比,使它成为管理慢性炎症的宝贵选择.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

(6A,11B,16A,17A)-6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-硫代羧酸 6α,9α-Difluoro-11β,17α-Dihydroxy-16α-Methyl-3-Oxo-Androsta-1,4-Diene-17β-Carbothioic Acid 80473-92-3
6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-羧酸 6α,9α-Difluoro-11β,17α-Dihydroxy-16α-Methyl-3-Oxoandrosta-1,4-Diene-17β-Carboxylic Acid 28416-82-2
氟米松 Flumetasone 2135-17-3

合成工艺路线路线简述

  • 合成目标产物 Fluticasone Furoate 主要起始原料 6α,9α-Difluoro-17α-(Furan-2-yl)Carbonyloxy-11β-Hydroxy-16α-Methyl-3-Oxoandrosta-1,4-Diene-17β-Carbothioic Acid And Bromofluoromethane
  • (文献来源)合成步骤主要原料 6α,9α-Difluoro-17α-(Furan-2-yl)Carbonyloxy-11β-Hydroxy-16α-Methyl-3-Oxoandrosta-1,4-Diene-17β-Carbothioic Acid 和 Bromofluoromethane
在 氨体系中,用 甲醇 作为反应溶剂,化学反应 0.08H,反应生成 糠酸氟替卡松
参考文献:Method For The Production Of Fluoromethyl Esters Of Androstan-17 Beta Carboxylic Acids
标题:Method For The Production Of Fluoromethyl Esters Of Androstan-17 Beta Carboxylic Acids
摘要:本文描述了从保护中间体和/或试剂出发制备单氟甲基有机生物活性化合物的过程,以获得如丙酸氟替卡松和富马酸氟替卡松等化合物,其中使用脱羧试剂xef2和brf3或使用fch2Sh作为试剂.

海关参考信息

专利信息


专利号:US-8697730-B2
优先权日:2007-10-26
标题 :5-lipoxygenase activating protein (FLAP) inhibitor
发明人：REWOLINSKI MELISSA VIRGINIA; SCHAAB KEVIN MURRAY; KING CHRISTOPHER DAVID; STOCK NICHOLAS SIMON
权利人:REWOLINSKI MELISSA VIRGINIA; SCHAAB KEVIN MURRAY; KING CHRISTOPHER DAVID; STOCK NICHOLAS SIMON; PANMIRA PHARMACEUTICALS LLC
摘要:Described herein are methods for the synthesis of 3-[5-(pyridin-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-[4-(2-methoxypyridin-5-yl)benzyl]-indol-2-yl]-2,2-dimethyl-propionic acid, pharmaceutically acceptable salts, pharmaceutically acceptable solvates thereof. Also described are pharmaceutical compositions suitable for oral administration to a mammal that include, as well as methods of using such oral pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.

专利号:CN-109574982-A
优先权日:2019-01-22
标 题 :A kind of method for solid acid catalyzed synthesis of vilanterol intermediate

专利号:EP-1930323-A1
优先权日:2004-03-11
标 题:Biphenyl compounds useful in the synthesis of muscarinic receptor antagonists

专利号:EP-1930323-B1
优先权日:2004-03-11
标 题:Biphenyl compounds useful in the synthesis of muscarinic receptor antagonists

专利号:CN-110423233-A
优先权日:2019-06-13
标题 :Preparation method for catalytic synthesis of vilanterol intermediate by modified graphene

专利号:AU-2007275931-A1
优先权日:2006-07-19
标 题:Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity

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主要参考文献


1: Albertson TE, Richards JR, Zeki AA. The combination of fluticasone furoate and vilanterol trifenatate in the management of asthma: clinical trial evidence and experience. Ther Adv Respir Dis. 2016 Feb;10(1):43-56. doi: 10.1177/1753465815619136. Epub 2015 Dec 14. Review. doi: 10.1007/s40265-015-0354-5. Review. Epub 2014 Dec 1. Review.
4: Matera MG, Capuano A, Cazzola M. Fluticasone furoate and vilanterol inhalation powder for the treatment of chronic obstructive pulmonary disease. Expert Rev Respir Med. 2015 Feb;9(1):5-12. doi: 10.1586/17476348.2015.986468. Epub 2014 Dec 6. Review. doi: 10.1007/s40265-014-0269-6. Review. doi: 10.2147/COPD.S32604. eCollection 2014. Review.
7: Bollmeier SG, Prosser TR. Combination of fluticasone furoate and vilanterol for the treatment of chronic obstructive pulmonary disease. Ann Pharmacother. 2014 Feb;48(2):250-7. doi: 10.1177/1060028013512615. Epub 2013 Nov 19. Review. doi: 10.4103/0022-3859.93260. Review. doi: 10.1517/14656566.2011.600688. Epub 2011 Jul 29. Review. doi: 10.1111/j.1365-2222.2010.03654.x. Epub 2010 Dec 1. Review. Review. doi: 10.1517/14656566.9.15.2707 . Review. Review. Review.

合成参考文献


摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
摘要:Kwiecień, H. U., Science of Synthesis: Knowledge Updates, (2024) 3, 1.
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