CAS: 38425-26-2; 4-Chloro-1-(P-Tolyl)Butan-1-One

上下游产品

toluene 4-Chlorobutanoyl chloride tri(p-tolyl)bismuth N-Methyl-N-methoxy-4-chlorobutanamide cyclopropyl-p-tolyl-methanone 1-Phenyl-3-p-tolyl-1,4,5,6-tetrahydro-pyridazine 3-p-Methylphenyl-3-hydroxy-N-(4'-p-methylphenyl-4'-oxobutyl)quinuclidinium Chloride 3-p-Methoxyphenyl-3-hydroxy-N-(4'-p-methylphenyl-4'-oxobutyl)quinuclidinium Chloride

📜1-(P-Tolyl)Cyclobutan-1-Ol置于manganese(II) Triflate,四丁基醋酸铵,溶剂黄146,Magnesium Chloride体系中,用 乙腈 作为反应溶剂,化学反应 3.5H,以76%的收率获得产物4-氯-4`-甲基苯丁酮
参考文献:锰催化的烷氧基自由基对环烷醇的电化学解构氯化反应.
标题:锰催化的烷氧基自由基对环烷醇的电化学解构氯化反应.
摘要:已经开发了锰催化的环烷醇的电化学解构氯化法.这种电化学方法可从醇中获得烷氧基,并具有广泛的底物范围,可将各种环丙醇和环丁醇转化为可合成使用的β-和γ-氯化酮(40个实例).此外,采用循环流电化学和连续在线纯化的组合以克为单位获得产物.
DOI:10.1021/acs.Orglett.9B03652

专利信息

专利号:US-2012302756-A1
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines
发明人：LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.

专利号:WO-2011103263-A2
优先权日:2010-02-19
标题:Process for synthesis of 2-substituted pyrrolidines and piperadines

专利号:EP-2536687-A2
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines