CAS: 223673-61-8; (R)-2-(2-Aminothiazol-4-yl)-N-(4-(2-((2-Hydroxy-2-Phenylethyl)Amino)Ethyl)Phenyl)Acetamide

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CAS号29676-71-9 2-氨基噻唑-4-乙酸 | CAS号521284-22-0 (alphaR)-alpha-...

(R)-2-(2-(1,3-Dioxoindolin-2-yl)Thiazol-4-yl)-N-(4-(2-((2-Hydroxy-2-Phenylethyl)Amino)Ethyl)Phenyl)Acetamide置于一水合肼体系中,用 乙醇 用作溶剂,化学反应 3.0H,以84%的收率获得米拉贝隆
参考文献:아미드 유도체의 염 및 그 제조방법
标题:아미드 유도체의 염 및 그 제조방법
摘要:This Text Appears To Be A Technical Document Discussing Chemical Compounds And Their Properties. Here Is The Translation In Chinese: 在本规范中,作为下述化学式1的酰胺衍生物的盐,[化学式1] 脂肪族或芳香族的二硫代磷酸酯或拉克坦结构环化的氨基酸(环化氨基酸)盐被引入.上述酰胺衍生物的盐对水分不吸收,稳定且在水中具有优异的溶解度.

专利信息

专利号:US-9815771-B2
优先权日:2014-08-06
标题 :Method for the synthesis of mirabegron and its derivatives
发明人：MARQUILLAS OLONDRIZ FRANCISCO; RIEGO ARBOLEYA ESTELA
权利人:INTERQUIM SA
摘要:The present invention refers to a method for the synthesis of a compound of formula (I), solvates, stereoisomers or salts thereof, a key intermediate in the synthesis of Mirabegron by reduction of an amide in the presence of an amine-boranecomplex, wherein the amine is an aniline.

专利号:US-2015111934-A1
优先权日:2013-10-07
标 题:Crystalline forms of an adrenergic agonist
发明人：BOVE ALESSIO; ALLEGRINI PIETRO; ATTOLINO EMANUELE
权利人:DIPHARMA FRANCIS SRL
摘要:The present invention relates to the acetate salt of Mirabegron, in particular in two novel crystalline forms, a process for their preparation and the use of said salt and its crystalline forms in the synthesis of Mirabegron with high yields and chemical purity.

专利号:EP-3177589-A1
优先权日:2014-08-06
标题 :Method for the synthesis of mirabegron and its derivatives

专利号:US-7982049-B2
优先权日:2001-10-30
标 题:α-form or β-form crystal of acetanilide derivative
发明人：KAWAZOE SOUICHIROU; SAKAMOTO KENICHIROU; AWAMURA YUJI; MARUYAMA TATSUYA; SUZUKI TAKAYUKI; ONDA KENICHI; TAKASU TOSHIYUKI
权利人:ASTELLAS PHARMA INC
摘要:To provide novel crystals useful as an ingredient for the production of a diabetes remedy. The invention is concerned with α-form crystal and β-form crystal of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide. The α-form crystal does not exhibit hygroscopicity and has stability such that it can be used as a medicine, and is useful for mass synthesis in the industrial production. The β-form crystal does not relatively exhibit hygroscopicity and is also useful as a production intermediate of the α-form crystal.

专利号:CN-110862359-A
优先权日:2019-11-19
标题:Synthesis of Mirabellon

专利号:CN-108727212-A
优先权日:2018-06-19
标 题 :Synthesis of a mirabegron intermediate (R)-2-hydroxy-N-(4-nitrophenethyl)-2-phenylacetamide