CAS: 219511-71-4; Boc-Guanidine
该化合物是一种受保护的guanidine衍生物,广泛用于有机合成和制药研究,其主要优势在于保护组,该组加强了反应期间的稳定性,同时允许在温和酸条件下有选择地取消保护.该化合物是建造含有guanidine的脚架的多用途中间体,在生物活性分子和消化器中十分流行.该组确保与一系列合成方法的兼容性,包括peptide联结和热循环形成.其晶体固态有利于处理和精确的异子测量控制.该产品在多步组合中具有可靠性,在多步组合中具有可靠性,保护组群战略至关重要."
- 英文名称Boc-Guanidine
- 中文名称叔丁氧羰基胍
- IUPAC名称tert-butyl N-(diaminomethylidene)carbamate
- 其它别名N-Boc-胍; Boc胍; Tert-Butyl Carbamimidoylcarbamate; Boc-Guanidine
- CAS编号219511-71-4
- MFCD编号:MFCD07369706
- EINECS号:694-484-6
- 分子式:C6H13N3O2分子量:159.19
- 产品CID: 1139432
- 产品分类有机原料→分子砌块→脂肪链类化合物
相似化合物
154476-57-0 50-01-1 21770-81-0物理性质
- 熔点170-175°C
- 沸点259°C at 760 mmHg
- 闪点110.4 °C
- 密度1.18 g/cm3
- pKa:9.60±0.46(预测)
- PSA:88.2
- LogP:0.40457
- 折射率1.498
- 蒸汽压0.0133mmHg at 25°C
- 溶解性Soluble In Most Alcohols, Esters (E.G., Ethyl Acetate), Ketones (E.G., Acetone), Acetonitrile, And Dichloromethane. Not Soluble In Diethyl Ether And Hexane.
- 敏感性易受潮
- 外观形态白色粉末
- 储存条件惰性气氛,存放于冰箱中, -20°C
- 产品应用该化合物用于中间药剂.
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
tert-butyl dicarbonatedi-tert-butyl dicarbonate guanidine hydr°Chloride guanidine hydrogen carbonate 1,4-dioxane 5-((tert-butyloxycarbonyl)guanidini°Carbonyl)-1H-pyrrole-2-carboxylic acid benzyl ester N'-tert-butoxycarbonyl-N-(6-diphenylphosphanylpyridine-2-carbonyl)guanidine N'-tert-butoxycarbonyl-N-(3-diphenylphosphanylbenzoyl)guanidine合成工艺路线路线简述
📜1,3-二(叔丁氧基羰基)胍 以 2-甲基四氢呋喃 用作溶剂,化学反应 1.0H,反应生成Boc-胍
参考文献:Process For The Preparation Of Substituted Pyrimidine Derivatives
标题:Process For The Preparation Of Substituted Pyrimidine Derivatives
摘要:本发明涉及制备取代嘧啶衍生物的过程,该衍生物可用作组胺h4受体调节剂合成中间体,以及h4调节剂合成中间体.
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
2915110000-甲酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9359327-B2
优先权日:2008-06-30
标题:Process for the preparation of substituted pyrimidine derivatives
发明人：CESCO-CANCIAN SERGIO; CHEN HONGFENG; GRIMM JEFFREY S; MANI NEELAKANDHA S; MAPES CHRISTOPHER M; PALMER DAVID C; PIPPEL DANIEL J; SORGI KIRK L; XIAO TONG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H 4 receptor modulators, and to intermediates in H4 modulator synthesis.
专利号:US-7838681-B2
优先权日:2003-05-07
标题 :Synthesis of substituted heterocyclic compounds
发明人：AL MOURABIT ALI; TRAVERT NATHALIE; ABOU-JNEID ROBERT; GHOULAMI SAID
权利人:CENTRE NAT RECH SCIENT; UNIV PARIS SUD
摘要:The invention relates to a method of synthesizing heterocyclic compounds. The invention is characterised in that it consists in opening a compound having formula (I), wherein: —X represents NH, O, S or a N-p group, p being a protective group, such as Boc or Troc; —Y represents N, O, S; —Z represents NH 2 or NH-p; and —R 1 represents a C 1 -C 6 alkoxy radical, aryloxy, such as phenyloxy, or a pyrrolyl radical, said radicals being optionally substituted, or the salts thereof, and the isomers of the aforementioned compounds. Moreover, the above-mentioned opening step is performed in conditions such as to produce a heterocycle having formula (II), wherein: —X, Y and Z are as defined above; —R 2 represents a —CHâ•?CH—CH 2 —NH—COR 1 or —CHâ•?CH—CH 2 —NH—CO group; and R 3 occupies one, two or three positions and represents a halogen. The invention can be used to synthesise natural products.
专利号:US-2007106077-A1
优先权日:2003-05-07
标 题:Synthesis of substituted heterocyclic compounds
专利号:CA-2524706-C
优先权日:2003-05-07
标 题:Synthesis of substituted heterocyclic compounds
专利号:CA-2524706-A1
优先权日:2003-05-07
标 题:Synthesis of substituted heterocyclic compounds
专利号:EP-1620440-B1
优先权日:2003-05-07
标 题 :Synthesis of substituted heterocyclic compounds
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2019) 1, 415.
📝 需求与反馈
尽可能描述清楚需求与问题信息
