CAS: 17996-12-2; Benzyl (6-Hydroxyhexyl)Carbamate

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CAS号4048-33-3 6-氨基-1-己醇 | CAS号501-53-1 氯甲酸苄酯 | CAS号25580-87-4 6-benzyloxycarb... | CAS号1885-14-9 氯甲酸苯酯 | CAS号1947-00-8 N-苄氧羰基-6-氨基己酸 | CAS号60-29-7 乙醚 | CAS号13139-17-8 苯甲氧羰酰琥珀酰亚胺 | CAS号137160-76-0 丙酮O-(苄氧羰基)肟 | CAS号4048-33-3 6-氨基-1-己醇 | CAS号1947-00-8 N-苄氧羰基-6-氨基己酸 | CAS号116784-97-5 (6-溴己基)氨基甲酸苄酯 | CAS号51224-11-4 BENZYL 6-IODOHE...

7-氨基-4-氯-3-甲氧基异香豆素置于lithium Aluminium Tetrahydride,氯化亚砜,碳酸氢钠体系中,用 四氢呋喃 用作溶剂,化学反应生成6-(Z-氨基)-1-己醇
参考文献:Further Characterization Of A Putative Serine Protease Contributing To The γ-Secretase Cleavage Of β-Amyloid Precursor Protein
标题:Further Characterization Of A Putative Serine Protease Contributing To The γ-Secretase Cleavage Of β-Amyloid Precursor Protein
摘要:The 3-Alkoxy-7-Amino-4-Chloro-Isocoumarins Jlk-6 And Jlk-2 Have Been Shown To Markedly Reduce The Production Of Amyloid Beta-Peptide (A Beta) By Amyloid-Beta Precursor Protein (App) Expressing Hek293 Cells By Affecting The Gamma-Secretase Cleavage Of App,With No Effect On The Cleavage Of The Notch Receptor. This Suggested That These Compounds Do Not Directly Inhibit The Presenilin-Dependent Gamma-Secretase Complex But More Likely Interfere With An Upstream Target Involved In Gamma-Secretase-Associated Pathway. The Mechanism Of Action Of These Compounds Is Unknown And There Are High Fundamental And Therapeutical Interests To Unravel Their Target. Isocoumarin Compounds Were Previously Shown To Behave As Potent Mechanism-Based Irreversible Inhibitors Of Serine Proteases,Suggesting That The Jlk-Directed Target Could Belong To Such Enzyme Family. To Get Further Insight Into Structure-Activity Relationships And To Develop More Potent Isocoumarin Derivatives,We Have Synthesized And Evaluated A Series Of Isocoumarin Analogues With Modifications At Positions 3,4 And 7. In Particular,The 7-Amino Group Was Substituted With Either Acyl,Urethane,Alkyl Or Aryl Groups,Which Could Represent Additional Interaction Sites. Altogether,The Results Highlighted The Essential Integrity Of The 3-Alkoxy-7-Amino-4-Chloro-Isocoumarin Scaffold For A Beta-Lowering Activity And Supported The Involvement Of A Seri Ne Protease,Or May Be More Generally,A Serine Hydrolase. The Newly Reported 7-N-Alkyl Series Produced The Most Active Compounds With An Ic50 Between 10 And 30 Mu M. Finally,We Also Explored Peptide Boronates,A Series Of Reversible Serine Protease Inhibitors,Previously Shown To Also Lower Cellular A Beta Production. The Presented Data Suggested They Could Act On The Same Target Or Interfere With The Same Pathway As Isocoumarins Derivatives. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2012.11.045

专利信息

专利号:US-10183962-B2
优先权日:2014-02-25
标 题:Synthetic oligomers of Neisseria meningitis serogroup X and process of preparing them
发明人：GILL DAVINDER; HARALE KISHORE; CHHIKARA MANOJ KUMAR
权利人:MSD WELLCOME TRUST HILLEMAN LABORATORIES PVT LTD
摘要:The present invention relates to synthesis of novel higher oligomers and process of preparing the same. In particular the present invention relates to the chemical synthesis of oligomers of Neisseria meningitidis serogroup X (‘hereinafter Men-X), more particularly tetramer. The present invention provides Men-X capsular oligomers obtained from synthetic pathway using purified saccharides of specific chain length and provides said novel oligomers as candidates for the development of conjugate vaccine against bacterial meningitis caused due to Men-X infections.

专利号:US-4599198-A
优先权日:1985-08-02
标题 :Intermediates in polypeptide synthesis
发明人：HOOVER DENNIS J
权利人:PFIZER
摘要:Bis(t-butoxycarbonyl) derivatives of phenylalanylhistidine as intermediates in the synthesis of rennin inhibiting polypeptides.