CAS: 174501-64-5; 1-Butyl-3-Methyl-1H-Imidazol-3-Ium Hexafluorophosphate(V)

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专利信息

专利号:US-2025215464-A1
优先权日:2022-07-08
标题 :Engineered enzyme for preparing a hydroxylated indanone intermediate useful in the synthesis of belzutifan
发明人：CHEUNG-LEE WAI LING; DIROCCO DANIEL A; GIL AGNIESZKA; HIRAGA KAORI; KIM JUNGCHUL; KOLEV JOSHUA; KOSJEK BIRGIT; MALONEY KEVIN M; SALEHI MARZIJARANI NASTARAN; MCINTOSH JOHN; MCMULLEN JONATHAN P; MOORE JEFFREY C; MURPHY GRANT S; PAN WEILAN; VELASQUEZ VELEZ JUAN E; VERMA DEEPTAK; WINSTON MATTHEW S; XIAO LI; ZHANG VICTORIA
权利人:MERCK SHARP & DOHME LLC
摘要:The present disclosure provides enzymes derived from the fungi Fusarium oxysporum c8D (“FoPip4H enzymesâ€?) having improved properties as compared to a naturally occurring wild-type enzyme including the capability of hydroxylating certain substituted indanones to provide optically pure 3-hydroxyindanones. Also provided are polynucleotides encoding the FoPip4H enzymes, host cells capable of expressing the FoPip4H enzymes, and processes for using the FoPip4H enzymes to synthesize (R)-4-fluoro-3-hydroxy-7-(methylsulfonyl)-2, 3-dihydro-1H-inden-1-one, a useful intermediate in the synthesis of belzutifan.

专利号:US-11779927-B2
优先权日:2019-07-25
标题:On-chip organic synthesis enabled by engine-and-cargo in an electrowetting-on-dielectric digital microfluidic device
发明人：MOON HYEJIN; TORABINIA MATIN
权利人:UNIV TEXAS
摘要:A method of moving a solvent without electrowetting properties on an electro-wetting-on-dielectric (EWOD) microfluidic device comprises disposing a first droplet of a first fluid having electrowetting properties on a surface of the EWOD microfluidic device; disposing a second droplet of a second fluid without electrowetting properties on the surface; applying a voltage to the surface to move the first droplet towards the second droplet; contacting the first droplet with the second droplet to form a encapsulated droplet, where the second droplet encapsulates the first droplet.

专利号:US-2024209408-A1
优先权日:2022-12-16
标 题 :Engineered 3-o-kinase variants and methods of use
发明人：ENTWISTLE DAVID; FORGEL STEPHANIE MARIE; KNIGHT ANDERS MATTHEW; KRAWCZYK MIKAYLA; PROVENCHER PHILIP; SHOUBBER AMANI; VROOM JONATHAN; WATTS DAVID; WONG LELAND
权利人:CODEXIS INC
摘要:The present invention provides engineered 3′O-kinase polypeptides useful for construction of materials used in template-independent polynucleotide synthesis, as well as compositions and methods of utilizing these engineered polypeptides. The present disclosure also describes one-pot methods for conversion of a natural or modified nucleoside to a nucleoside tetraphosphate or NQP.

专利号:WO-2023113033-A1
优先权日:2021-12-16
标题 :Gas diffusion electrode
发明人：KONDO SHOICHI; MAEDA SHINICHI; SHIGA NORIHITO
权利人:NISSAN CHEMICAL CORP
摘要:[Problem] The present invention addresses the problem of increasing the rate of reaction by controlling ammonium ions, which are generated by ammonia as the objective of the electrolytic synthesis of ammonia and protons that are supplied to the cathode, by means of the cathode and the cathode catalyst layer. [Solution] The present invention provides a gas diffusion electrode which is integrated with a catalyst layer that uses a material selected from the group consisting of cathode catalyst layer materials. Examples of the cathode catalyst layer materials include a fired body and an ionic liquid.

专利号:EP-4634200-A1
优先权日:2022-12-16
标题 :Enzymatic synthesis of ntp and nqp

专利号:EP-3310845-B1
优先权日:2015-06-15
标题:Use of additives to fine-tune the composition of carbonate units in the polymer formed by copolymerization of co2 with epoxide: application to the synthesis of polycarbonate-based block copolymers and of telechelics