CAS: 1711-09-7; 3-Bromobenzoylchloride

相似化合物

3132-99-8 56990-02-4 188813-04-9

上下游产品

CAS号591-18-4 1-溴-3-碘苯 | CAS号201230-82-2 carbon monoxide | CAS号585-76-2 3-溴苯甲酸 | CAS号98-88-4 苯甲酰氯 | CAS号3132-99-8 间溴苯甲醛 | CAS号39115-96-3 3-溴苄肼 | CAS号35306-74-2 3-溴-N-丙基苯甲酰胺 | CAS号49834-22-2 3-溴-N-甲基苯甲酰胺 | CAS号4885-18-1 (3-溴苯基)二甲胺 | CAS号93002-99-4 6-(3-Bromopheny... | CAS号1829-88-5 (3-bromobenzoyl... | CAS号188747-28-6 3-bromo-N-(6-me... | CAS号3469-20-3 2,3-二苯基吲哚 | CAS号24167-51-9 3-溴-N,N-二甲基苯甲酰胺

间溴苯甲酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 用作溶剂,化学反应生成3-溴苯甲酰氯
参考文献:芳基环丙胺-伏立诺他偶联物的癌细胞选择性靶向
标题:芳基环丙胺-伏立诺他偶联物的癌细胞选择性靶向
摘要:与传统的大分子药物递送系统相比,小分子抗癌药物递送具有许多优点.我们之前开发了苯基环丙胺 (Pcpa)-药物缀合物 (Pdc) 作为基于小分子的药物递送载体,用于靶向赖氨酸特异性脱甲基酶 1 (Lsd1) 过表达的癌症.在本研究中,我们将这种 Pdc 策略应用于 Hdac 抑制性抗癌药物伏立诺他 (Vorinostat).在三种合成的 Pcpa 或芳基环丙胺 (Acpa)-伏立诺他缀合物1,9和32中,具有 4-氧苄基连接体的缀合物32在缓冲溶液中表现出足够的稳定性,有效的 Lsd1 抑制,有效的 Lsd1 依赖性伏立诺他释放以及有效和选择性的抗增殖作用对表达 Lsd1 的人乳腺癌和小细胞肺癌细胞系的活性.这些结果表明缀合物在癌细胞中选择性地释放伏立诺他.类似的策略可能适用于其他抗癌药物.
Doi:10.1021/acsmedchemlett.2C00126

专利信息

专利号:US-11130764-B2
优先权日:2017-02-17
标题 :Analogs of vincamine and uses thereof
发明人：HUIGENS III ROBERT WILLIAM; NORWOOD IV VERRILL M; LUESCH HENDRIK
权利人:UNIV FLORIDA
摘要:The present disclosure provides compounds of any one of Formulae (I′), (I), (IA), (II′), (II), (IIA), (IIIA), (III″), (III′), (III), (IIIA), (IV), (V′), (V), (VI), (VII), (VIII′), (VIII), (IX′), (IX), and (X). The compounds described herein may be useful in treating and/or preventing a broad range of diseases (e.g., proliferative disease (e.g., cancers (e.g., non-small cell lung cancer, or glioma), inflammatory diseases, autoimmune diseases), CNS disorder (e.g., drug addiction), metabolic disorder (e.g., diabetes), or infectious disease (e.g., bacterial infection or parasitic infection (e.g., malaria))). Also provided in the present disclosure are pharmaceutical compositions, methods of synthesis of a compound described herein, kits, methods, and uses including or using a compound described herein.

专利号:RU-2014320-C1
优先权日:1987-09-15
标题:Method of synthesis of propenoic acid derivatives and their stereoisomers

专利号:CN-103864722-A
优先权日:2012-12-13
标题 :Synthesis of a Novel [4-(4-Phenoxymethyl)benzoyl]piperazine Derivatives and Their Anticancer Drug Actions

专利号:US-2012009151-A1
优先权日:2007-12-21
标题 :Triazines And Related Compounds Having Antiviral Activity, Compositions And Methods Thereof
发明人：HAN AMY QI; COBURN GLEN A; PROVONCHA KATHLEEN P; ROTSHTEYN YAKOV
权利人:HAN AMY QI; COBURN GLEN A; PROVONCHA KATHLEEN P; ROTSHTEYN YAKOV; PROGENICS PHARM INC
摘要:Disclosed herein are novel triazines and related compounds, the synthesis thereof, and compositions, including pharmaceutical compositions, comprising the novel triazines and related compounds. Such novel triazines and related compounds function to inhibit or block entry of viruses of the Flaviviridae family, including Hepatitis C virus (HCV), into cells that are susceptible to virus infection. These compounds are useful for the treatment, therapy and/or prophylaxis of viral diseases and infection, including HCV infection.

专利号:WO-2009054923-A2
优先权日:2007-10-24
标 题 :Synthesis and crystalline forms of cb-1 antagonist/inverse agonist

专利号:US-2010292282-A1
优先权日:2007-10-24
标题:Synthesis and crystalline forms of cb-1 antagonist/inverse agonist
发明人：CAMPOS KEVIN R; CHEN CHENG-YI; FOLEY JENNIFER R; HILLIER MICHAEL; JEN WENDY S; KASSIM AMUDE M; KLAPARS ARTIS; PERESYPKIN ANDREY V; ROSNER THORSTEN; SAVARIN CECILE G; TUDGE MATTHEW; VARIANKAVAL NARAYAN; VYDRA VICKY; ZHAO DALIAN
权利人:CAMPOS KEVIN R; CHEN CHENG-YI; FOLEY JENNIFER R; HILLIER MICHAEL; JEN WENDY S; KASSIM AMUDE M; KLAPARS ARTIS; PERESYPKIN ANDREY V; ROSNER THORSTEN; SAVARIN CECILE G; TUDGE MATTHEW; VARIANKAVAL NARAYAN; VYDRA VICKY; ZHAO DALIAN
摘要:The present invention relates to a process for producing crystalline 3-[(1S)-1-(1-{(S)-(4-chlorophenyl)[3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]methyl}azetidin-3-yl)-2-fluoro-2-methyl-propyl]-5-fluorobenzonitrile, and novel salts, solvates, hydrates and polymorphs thereof.