CAS: 162607-18-3; (5-Chlorothiophen-2-yl)Boronic Acid

该化合物是一种多用途的博尔尼酸衍生物,广泛用于铃木-米亚乌拉交叉反应,能够合成复杂的双aryl和异丙烯化合物,其5-氯替代能增强催化变异的活性性和选择性,使其对制药和农用化学应用具有价值.硫苯基骨质有助于其稳定性和与多种反应条件的兼容性.该复合物对于建造含有硫的乙基循环特别有用,该循环在生物活性分子中十分普遍.高纯度能能确保要求合成工作流程的一贯性能.建议在惰性条件下进行适当处理,以保持其再活性.建议低温在干燥环境中储存,以保持一段时间的稳定性.

英文名称(5-Chlorothiophen-2-yl)Boronic Acid
中文名称5-氯噻吩-2-硼酸
IUPAC名称(5-chlorothiophen-2-yl)boronic acid
其它别名(5-氯噻吩-2-基)硼酸; 5-Chlorothiophene-2-Boronic Acid
CAS编号162607-18-3
MFCD编号:MFCD00236030
EINECS号:672-311-5
分子式:C4H4BClO2S
分子量:162.39
产品CID: 822844
产品分类有机原料→分子砌块→芳杂环类化合物→噻吩类化合物

相似结构搜索
InChIKey: JFCLNCVCDFUJPO-UHFFFAOYSA-N
InChI=1S/C4H4BClO2S/c6-4-2-1-3(9-4)5(7)8/h1-2,7-8H…
计算化学: 氢键受体数3.0氢键供体数2可旋转键数1

相似化合物

635305-24-7 2222020-36-0 1150114-72-9

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(吸入)
急性毒性类别4(经皮)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H332 |吸入有害.
H312 |皮肤接触有害.
防范说明P264-P280-P302+P352-P362
危险等级IRRITANT
UN编号NONH for all modes of transport
危险品标志Xi
安全声明37/39-26-36
危险类别码36/37/38
WGK Germany3

欧盟法规

C&L通报

合成工艺路线路线简述

专利信息

专利号:US-9951062-B2
优先权日:2012-12-14
标题 :Substituted 1 H-pyrrolo [2, 3-b] pyridine and 1 H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANIPISETTY VENU BABU; TALLURI SURESHKUMAR; APPALANENI RAJENDRA P
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:Compounds according to Formulas I, IA or IB: n nto pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and/or disorders such as cancer, stroke, cardiovascular, obesity and type II diabetes.

专利号:US-7648986-B2
优先权日:2002-01-10
标题:Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors
发明人：NAGARATHNAM DHANAPALAN; KHIRE UDAY; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; WANG CHUNGUANG; HART BARRY; WEBER OLAF; LYNCH MARK; ZHANG LEI; WANG LEI
权利人:BAYER HEALTHCARE LLC
摘要:Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

专利号:US-7737166-B2
优先权日:2005-08-17
标题:Antifungal bicyclic hetero ring compounds
发明人：KAWAKAMI KATSUHIRO; KANAI KAZUO; HORIUCHI TAKAO; TAKESHITA HIROSHI; KOBAYASHI SYOZO; SUGIMOTO YUICHI; ACHIWA ISSEI; KUROYANAGI JUNICHI
权利人:DAIICHI SANKYO CO LTD
摘要:A 1,6-Î²-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and specifically or selectively, an antifungal effect based on its functional mechanism of 1,6-Î²-glucan synthesis inhibition. Also provided is a drug, a salt or hydrate thereof, especially an antifungal that contains the compound. Concretely, provided is a compound of the following formula (I), its salt or hydrate, and a drug or antifungal containing, as the active ingredient, the compound, its salt or hydrate: