CAS: 112839-95-9; (S)-3-Amino-2-Oxetanone P-Toluenesulfonic Acid Salt

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26054-60-4 98632-91-8 149572-97-4

上下游产品

(S)-3-(tert-butoxycarbonylamino)-oxetan-2-one toluene-4-sulfonic acid -2-oxetanone3(S)-(triphenylmethyl)amino-2-oxetanone (S)-N-(tert-butoxycarbonyl)serine L-cysteine dimethylsulfonium bis(p-toluenesulfonic acid) L-azidoalanine hydr°Chloride -2-oxetanone3(S)-(triphenylmethyl)amino-2-oxetanone (S)-4-(benzyloxy)-N-(2-oxo-3-oxetanyl)benzamide

合成工艺路线路线简述

    📜Boc-L-丝氨酸置于tsoh,三苯基膦,三氟乙酸,偶氮二甲酸二乙酯体系中,化学反应生成(S)-3-氨基-2-氧杂环酮对甲苯磺酸
    参考文献:Peptide Nucleic Acid Conjugates
    标题:Peptide Nucleic Acid Conjugates

    海关参考信息

    专利信息


    专利号:US-5200526-A
    优先权日:1987-04-27
    标题:Syntheses of optically pure α-amino acids from 3-amino-2-oxetanone salts
    发明人:ARNOLD LEE D; VEDERAS JOHN C
    权利人:UNIV ALBERTA
    摘要:A process for the preparation of optically pure α-amino acids comprising the nucleophilic ring-opening of 3-amino-2-oxetanone salts. N-Protected serine β-lactones are deprotected to form heretofore unknown 3-amino-2-oxetanone and its corresponding salts. In turn these previously unknown 3-amino-2-oxetanone salts may be used in the synthesis of other novel or rare stereochemically-pure free amino acids.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1021/jm950632+
    摘要:Sun G, Uretsky NJ, Wallace LJ, Shams G, Weinstein DM, Miller DD. Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor agonists and antagonists. J Med Chem. 1996 Oct 25;39(22):4430–8. doi: 10.1021/jm950632+.
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