2-二溴甲基噻唑置于silver Nitrate体系中,用 乙醇 用作溶剂,化学反应 0.25H,以100%的收率获得2-醛基噻唑 参考文献:1,2,3-Triazolo[5,1-B]Thiazoles; Synthesis And Properties 标题:1,2,3-Triazolo[5,1-B]Thiazoles; Synthesis And Properties 摘要:The Synthesis Of 1,2,3-Triazolo[5,1-B]Thiazole (15) And Its 3-Methyl-(16) And 3-Phenyl-(17) Derivatives Is Reported,Together With Their Spectra,Quaternisation,And Ring Opening Reactions. Doi:10.1016/s0040-4020(01)87090-3
专利信息
专利号:WO-2021260722-A1 优先权日:2020-06-21 标 题:Design, synthesis of novel oxyindole inhibitors of denv rna dependent rna polymerase 发明人:GUNDLA RAMBABU; ASTHANA SHAILENDRA; BHATTACHARYYA SANKAR; MADDIPATI VENKATANARAYANA CHOWDARY; MITTAL LOVIKA; KAUR JASKARAN; RAWAT YOGITA 权利人:TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE; GANDHI INSTITUTE OF TECH AND MANAGEMENT 摘要:The present invention is drawn to novel compounds of formula I, II and III, including any conformational isomeric form, salts and solvates for inhibition of DENV RNA dependent and RNA polymerase. The present invention also discloses a process of synthesis of the compounds, compositions comprising the said compounds and use of the compounds and treatment comprising the compounds of the present invention.
专利号:WO-2017089470-A1 优先权日:2015-11-27 标 题:Process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases 发明人:HOFMANN DAGMAR; HOFMANN JOSEFA; HEINRICH MARKUS 权利人:Friedrich-Alexander-Universität Erlangen-Nürnberg 摘要:The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.
专利号:US-2013338369-A1 优先权日:2011-03-07 标 题 :Process for the Synthesis of Aminobiphenylene 发明人:HEINRICH MARKUS; PRATSCH GERALD 权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE 摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.
专利号:WO-2022127640-A1 优先权日:2020-12-16 标题:Process for synthesis of furan-based diamines 发明人:GUO RUIJING; PIRES RAUL; BEUCK SASKIA; LATORRE MARTINEZ IRENE CRISTINA; PAN XIANGCHENG; JIANG YUAN 权利人:COVESTRO DEUTSCHLAND AG; GUO RUIJING 摘要:The invention provides a process for the synthesis of furan-based diamines based on renewable resources.
专利号:US-8557979-B2 优先权日:2004-06-10 标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation 发明人:CHOI WOO-BAEG; KOWALIK EWA 权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC 摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.
专利号:US-7732605-B2 优先权日:2005-03-29 标题 :Synthesis of diketopiperazines 发明人:HAYASHI YOSHIO 权利人:NEREUS PHARMACEUTICALS INC 摘要:Disclosed herein are methods for synthesizing diketopiperazines with enantiomeric excess by inducing cyclization of an α-keto acid with an acid catalyst.
[参考文献]: Amanda Silva De Miranda, Et Al. Design, Synthesis, Antinociceptive And Anti-Inflammatory Activities Of Novel Piroxicam Analogues. Molecules. 2012 Nov 28;17(12):14126-45. [参考文献]: Armel A Agbodjan, Et Al. Asymmetric Synthesis Of An N-Acylpyrrolidine For Inhibition Of Hcv Polymerase. J Org Chem. 2008 Apr 18;73(8):3094-102.
合成参考文献
摘要:Koutentis, P. A.; Ioannidou, H. A., Science of Synthesis Knowledge Updates, (2010) 1, 374. 摘要:Demchuk, O. M.; Stankevič, M.; Pietrusiewicz, K. M., Science of Synthesis Knowledge Updates, (2015) 1, 303. 摘要:Shibatomi, K., Science of Synthesis Knowledge Updates, (2017) 2, 400. 摘要:Chiang, P.-C.; Bode, J. W., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 663. 参考文献:10.1021/jo800062c 摘要:Agbodjan AA, Cooley BE, Copley RC, Corfield JA, Flanagan RC, Glover BN, Guidetti R, Haigh D, Howes PD, Jackson MM, Matsuoka RT, Medhurst KJ, Millar A, Sharp MJ, Slater MJ, Toczko JF, Xie S. Asymmetric synthesis of an N-acylpyrrolidine for inhibition of HCV polymerase. J Org Chem. 2008 Apr 18;73(8):3094–102. doi: 10.1021/jo800062c.