CAS: 1018-71-9; 3-Chloro-4-(3-Chloro-2-Nitrophenyl)-1H-Pyrrole

上下游产品

3-Chloro-4-(3'-Chloro-2'-Nitrophenyl)-N-(Tips)Pyrrole 1126425-93-1
3-氯-4-(2-氨基-3-氯苯基)吡咯 Aminopyrrolnitrin 16386-65-5

📜3-Chloro-4-(3'-Chloro-2'-Nitrophenyl)-N-(Tips)Pyrrole置于四丁基氟化铵体系中,用 四氢呋喃 用作溶剂,以74%的收率获得硝吡咯菌素
参考文献:Synthesis Of Pyrrolnitrin And Related Halogenated Phenylpyrroles
标题:Synthesis Of Pyrrolnitrin And Related Halogenated Phenylpyrroles
摘要:A General Approach To Halogenated Arylpyrroles,Including The Antifungal Natural Product Pyrrolnitrin,Is Described Using Newly Synthesized Halogenated Pyrroles And 2,6-Disubstituted Nitrobenzenes Or 2,6-Disubstituted Anilines.
Doi:10.1021/ol8026957

专利信息

专利号:US-5662898-A
优先权日:1990-08-20
标 题 :Genes for the synthesis of antipathogenic substances
发明人：LIGON JAMES M; HILL DWIGHT STEVEN; LAM STEPHEN TING; HAMMER PHILIP E
权利人:CIBA GEIGY CORP
摘要:The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.

专利号:US-2013123543-A1
优先权日:2010-04-14
标 题:Polyacetylenic Compounds with Anti-Fungal Activity Derived from the Bacterium Collimonas and Methods for the Preparation and Identification Thereof
发明人：FRITSCHE KATHRYN; LEVEAU JOHANNES HENRICUS JOSEPHUS; DE BOER WIETSE; VAN VEEN JOHANNES ANTONIE
权利人:FRITSCHE KATHRYN; LEVEAU JOHANNES HENRICUS JOSEPHUS; DE BOER WIETSE; VAN VEEN JOHANNES ANTONIE; NETHERLANDS INST OF ECOLOGY
摘要:The present invention relates to isolated nucleic acid sequences involved in, or capable of the biosynthesis of polyacetylenic compounds with anti-fungal activity and especially isolated nucleic acid sequences derived from Collimonas fungivorans . Further, the present invention relates to methods for identifying the present isolated nucleic acids, the use thereof for identification of homologous nucleic acids in other organisms or the use thereof for the biosynthesis of polyacetylenic compounds with anti-fungal activity. Further, the present invention relates to novel polyacetylenic compounds with anti-fungal activity. Specifically, the present invention relates to isolated nucleic acids encoding one or more proteins involved in the synthesis of a polyacetylenic compound with antifungal activity wherein said isolated nucleic acid comprises a nucleic acid sequence having at least 70%, preferably at least 80%, more preferably at least 90%, most preferably at least 95% identity with SEQ ID No. 1.

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-9233920-B2
优先权日:2010-06-11
标题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-6051383-A
优先权日:1995-06-26
标题:Sequences for production of 2,4-diacetylphloroglucinol and methods
发明人：THOMASHOW LINDA S; BANGERA MAHALAXMI; WELLER DAVID M; COOK R JAMES
权利人:US AGRICULTURE; UNIV WASHINGTON
摘要:DNA sequences which function specifically in the synthesis of 2,4-diacetylphloroglucinol (Phl) are described. The sequences include phl genes which encode phl gene proteins and coding and regulatory sequences for production of Phl as well as sequences containing phl genes, which sequences have the capability of conferring or enhancing Phl biosynthetic capability in bacterial strains. The transformed strains are useful as biocontrol agents against fungal pathogens.

专利号:US-9968097-B2
优先权日:2012-05-30
标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction
发明人：WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND
权利人:BAYER CROPSCIENCE AG
摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.