专利号:US-5861532-A 优先权日:1997-03-04 标 题:Solid-phase synthesis of N-alkyl amides 发明人:BROWN EDWARD G; NUSS JOHN M 权利人:CHIRON CORP 摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.
专利号:US-6133409-A 优先权日:1996-12-19 标 题:Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds 发明人:SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F 权利人:AVENTIS PHARM PROD INC 摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.
专利号:US-6710208-B2 优先权日:1996-12-19 标题 :Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds 发明人:SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F 权利人:AVENTIS PHARMA INC 摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.
专利号:US-11745159-B2 优先权日:2017-10-20 标题:Heated nanowells for polynucleotide synthesis 发明人:MARSH EUGENE P; INDERMUHLE PIERRE F; PECK BILL JAMES 权利人:TWIST BIOSCIENCE CORP 摘要:Defined sequence RNA synthesis by 3′→5′ direction is now well established and currently in use for synthesis and development of vast variety of therapeutic grade RNA and Si RNA etc. A number of such synthetic RNA requires a modification or labeling of 3′-end of an oligonucleotide. The synthesis of 3′-end modified RNA requiring lipophilic, long chain ligands or chromophores, using 3′→5′ synthesis methodology is challenging, requires corresponding solid support and generally results in low coupling efficiency and lower purity of the final oligonucleotide in general because of large amount of truncated sequences containing desired hydrophobic modification. We have approached this problem by developing reverse RNA monomer phosphoramidites for RNA synthesis in 5′→3′-direction. They lead to very clean oligonucleotide synthesis allowing for introduction of various modifications at the 3′-end.
专利号:US-2024051897-A1 优先权日:2022-07-26 标题:Synthesis of complex 15n-labeled molecules 发明人:DORSHEIMER JULIA; ROVIS TOMISLAV 权利人:UNIV COLUMBIA 摘要:Methods for conversion of a broad range of amines to their 15N isotopic counterparts and the compounds produced thereby.
专利号:US-5175302-A 优先权日:1987-07-13 标 题 :Nucleophilic fluoroalkylation of aldehydes 发明人:STAHLY G PATRICK 权利人:ETHYL CORP 摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.
参考标题:Synthesis Of Novel 5,6-Dehydrokawain Analogs As Osteogenic Inducers And Their Action Mechanisms 作者:Momochika Kumagai,Keisuke Nishikawa,Takashi Mishima,Izumi Yoshida,Masahiro Ide,Keiko Koizumi,Munetomo Nakamura,Yoshiki Morimoto |发布日期:2017.6 摘要:Protein (Bmp) And Activation Of P38 Mapk Signaling Pathways. Compounds 14 And 21 Also Inhibited Rankl-Induced Osteoclast Differentiation Of Raw264 Cells. These Results Indicated That Novel 5,6-Dehydrokawain Analogs Not Only Increase Osteogenic Activity But Also Inhibit Osteoclast Differentiation, And Could Be Potential Lead Compounds For The Development Of Anti-Osteoporosis Agents.
合成参考文献
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 339. 摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, . 摘要:Huang, Y.; Dömling, A., Science of Synthesis: Multicomponent Reactions, (2013) 1, 261. 摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198 参考文献:10.1107/s1600536810048026 摘要:Sarveswari S, Vijayakumar V, Prasath R, Narasimhamurthy T, Tiekink ER. (2E)-3-(4-Eth-oxy-phen-yl)-1-(2-methyl-4-phenyl-quinolin-3-yl)prop-2-en-1-one monohydrate. Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 24;66(Pt 12):o3284.