CAS: 93239-37-3; (6A)-21-(Acetyloxy)-17-Hydroxy-6-Methylpregna-1,4,9(11)-Triene-3,20-Dione
该化合物是分子结构复杂,包括多种功能组,如氢氧基和乙酸盐,该化合物是类固醇核的衍生物,对其生物活动至关重要;典型的成分是类固醇激素的特性,包括抗炎和代谢效应;二氧化物组的存在表明潜在的再活动性和生物相互作用,而乙酸组可能提高它的溶性和生物利用率;该化合物经常因其药理学应用,特别是内分泌学和药理学领域的应用而进行研究;该化合物的化学化学编号为93239-37-37,允许在化学数据库中精确识别,便利研究和开发;与许多类固醇一样,其使用受到监管审查,因为可能对健康,特别是在运动环境中的健康产生副作用和影响.
- 英文名称(6A)-21-(Acetyloxy)-17-Hydroxy-6-Methylpregna-1,4,9(11)-Triene-3,20-Dione
- 中文名称(6a)-21-(乙酰氧基)-17-羟基-6-甲基孕甾-1,4,9(11)-三烯-3,20-二酮
- 其它别名Pregna-1,4,9(11)-triene-3,20-dione,17,21-dihydroxy-6a-methyl-,21-acetate (6CI,7CI)
- CAS编号93239-37-3
- FDA UNII编号:LEM4KCX4XJ
- 分子式:C24H30O5分子量:398.49
- 产品CID: 1970786
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
910-99-6 77017-20-0 52092-12-3物理性质
MSDS等安全信息
合成工艺路线路线简述
- 53-36-1 = 93239-37-3
反应条件:1.1 Reagents: Methanesulfonyl Chloride,Sulfur Dioxide Solvents: Dimethylformamide,Tetrahydrofuran; Cooled
标题:Preparation Of Non-Hormonal Steroid Modulators Of Nf-Kβ For Treatment Of Diseases
参考文献:United States]
53-36-1 = 93239-37-3
反应条件:1.1 Reagents: Methanesulfonyl Chloride,Sulfur Dioxide Solvents: Dimethylformamide,Tetrahydrofuran; 0 °C
标题:Non-Hormonal Steroid Modulators Of Nf-Kb For Treatment Of Disease
参考文献:World Intellectual Property Organization]
1234497-56-3 = 93239-37-3
反应条件:1.1 Reagents: 1,1,2,2-Tetrafluoro-N,N-Dimethylethanamine Solvents: 1,4-Dioxane; 3 H,-60 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
标题:Method For Preparation Of δ9(11)-Steroid Compound
参考文献:China]
53-36-1 = 93239-37-3
反应条件:1.1 Reagents: Methanesulfonyl Chloride,Sulfur Dioxide Solvents: Dimethylformamide,Tetrahydrofuran; Cooled
标题:Preparation Of Non-Hormonal Steroids As Modulators Of Nf-Kb For The Treatment Of Disease
参考文献:World Intellectual Property Organization]
= 93239-37-3 [标题:Reaction Conditions
标题:Non-Hormonal Steroid Modulators Of Nf-Kb For Treatment Of Disease
参考文献:United States]
53-36-1 = 93239-37-3
反应条件:1.1 Reagents: N-Bromosuccinimide,Sulfur Dioxide Catalysts: 4-(Dimethylamino)Pyridine Solvents: 2-Methylpyridine; -10 °C; 30 Min,-10 °C
标题:Preparing Method And Application Of 9,11-Double Bond Steroidal Compound
参考文献:China]
53-36-1 = 93239-37-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Pyridine; 30 Min,0 - 5 °C1.2 Reagents: Sulfur Dioxide; 0 - 5 °C
标题:Synthesis Of 6α-Methyl-11,17α,21-Trihydroxy-9α-Fluoro-1,4-Pregnadiene-3,20-Dione As A Key Intermediate For Fluoromethalone
作者:He,Xin; Zhang,Ting-Jian; Liang,Jing-Wei; Yang,Su; Wu,Qing-Xia; Et Al
参考文献:Jingxi Huagong Zhongjianti 日期:2014 卷标:44(5) 页码:46-48]
53-36-1 = 93239-37-3
反应条件:1.1 Reagents: Methanesulfonyl Chloride,Sulfur Dioxide Solvents: Dimethylformamide,Tetrahydrofuran; Cooled
标题:Preparation Of Non-Hormonal Steroid Modulators Of Nf-Kb For Treatment Of Disease
参考文献:World Intellectual Property Organization]
= 93239-37-3 [标题:Reaction Conditions
标题:6α-Methyl Steroids
参考文献:Federal Republic Of Germany
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
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合成参考文献
参考文献:10.1016/j.bbrc.2023.08.050
摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
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