CAS: 90004-09-4; 7-Aminoquinazolin-4(1H)-One

英文名称7-Aminoquinazolin-4(1H)-One
中文名称7-氨基喹唑啉-4(3H)-酮
IUPAC名称7-aminoquinazolin-4(3H)-one
其它别名7-氨基-3,4-二氢喹唑啉-4-酮; 7-Aminoquinazolin-4-Ol
CAS编号90004-09-4
MFCD编号:MFCD00234413
EINECS号:696-516-4
分子式:C8H7N3O分子量:161.16
产品CID: 1930594
产品分类有机原料→分子砌块→芳杂环类化合物→喹唑啉类化合物

相似结构搜索
InChIKey: WQXFFJUUIIGPRY-UHFFFAOYSA-N
InChI=1S/C8H7N3O/c9-5-1-2-6-7(3-5)10-4-11-8(6)12/h1-4H,9H2,(H,10,11,12)
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数0.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H319-H315-H335
防范说明P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

上下游产品

CAS号20872-93-9 7-硝基喹唑啉-4(3H)-酮 | CAS号619-17-0 2-氨基-4-硝基苯甲酸 | CAS号202197-77-1 7-碘喹唑啉-4(1H)-酮

合成工艺路线路线简述

20872-93-9 = 90004-09-4
反应条件:1.1 Reagents: Ammonium Formate Catalysts: Palladium Solvents: Methanol; 10 Min,65 °C
标题:Efficient Synthesis Of Thiazoloquinazolinone Derivatives
作者:Alexandre,Francois-Rene; Berecibar,Amaya; Wrigglesworth,Roger; Besson,Thierry
参考文献:Tetrahedron Letters 日期:2003 卷标:44(24) 页码:4455-4458]

86222-55-1 = 90004-09-4
反应条件:1.1 Reagents: Iron,Ammonium Chloride Solvents: Ethanol; 4 H,Reflux
标题:Structure-Based Drug Design,Synthesis And Screening Of Mmaa1 Inhibitors As Novel Anti-Tb Agents
作者:Veeravarapu,Hymavathi; Malkhed,Vasavi; Mustyala,Kiran Kumar; Vadija,Rajender; Malikanti,Ramesh; Et Al
参考文献:Molecular Diversity 日期:2021 卷标:25(1) 页码:351-366]

20872-93-9 = 90004-09-4
反应条件:1.1 Reagents: Tin Dichloride Dihydrate Solvents: Ethyl Acetate; 8 H,Reflux; Reflux -> Rt1.2 Reagents: Sodium Carbonate Solvents: Water; Rt
标题:Synthesis And Sar Optimization Of Quinazolin-4(3H)-Ones As Poly(Adp-Ribose)Polymerase-1 Inhibitors
作者:Kulkarni,Shridhar S.; Singh,Satyakam; Shah,Janki R.; Low,Woon-Kai; Talele,Tanaji T.
参考文献:European Journal Of Medicinal Chemistry 日期:2012 卷标:50 页码:264-273]

20872-93-9 = 90004-09-4
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol,Dimethylformamide
标题:Substituted 2H-Isoquinolin-1-One As Potent Rho-Kinase Inhibitors. Part 1: Hit-To-Lead Account
作者:Wu,Frank; Buettner,Frank H.; Chen,Rhonda; Hickey,Eugene; Jakes,Scott; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(11) 页码:3235-3239

📜2-氨基-4-硝基苯甲酸置于palladium 10% On Activated Carbon,氢气体系中,用乙醇作为反应溶剂,化学反应生成 7-氨基喹唑啉-4-醇
参考文献:作为神经保护剂的药用化合物
标题:作为神经保护剂的药用化合物
摘要:本发明公开了一类作为神经保护剂的药用化合物,其为神经元型一氧化氮合酶‑突触后密度蛋白‑95(nnos‑psd95)的解耦联剂,其为具有通式(ⅰ)苯环衍生物或其药学上可接受的盐.本申请进一步公开了该类化合物的制备方法以及其用于预防和治疗受神经元损伤影响引起的疾病的用途.

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合成参考文献

参考文献:10.1007/s11030-020-10107-0
摘要:Veeravarapu H, Malkhed V, Mustyala KK, Vadija R, Malikanti R, Vuruputuri U, Muthyala MKK. Structure-based drug design, synthesis and screening of MmaA1 inhibitors as novel anti-TB agents. Mol Divers. 2021 Feb;25(1):351–66. doi: 10.1007/s11030-020-10107-0.