= 89-00-9 反应条件:1.1 Reagents: Acetic Acid,Sulfuric Acid,Ozone Solvents: Water1.2 Reagents: Hydrogen Peroxide Solvents: Water 标题:Ozonolysis Of Quinolines: A Versatile Synthesis Of Polyfunctional Pyridines 作者:O'Murchu,C. 参考文献:Synthesis 日期:1989 卷标:(11) 页码:880-82]
= 89-00-9 [标题:Reaction Conditions 标题:Electrolytic Oxidation Of Quinoline And 3-Picoline 作者:Kulka,Marshall 参考文献:Journal Of The American Chemical Society 日期:1946 卷标:68 页码:2472-3]
148-24-3 = 89-00-9 反应条件:1.1 Reagents: Hydrogen Peroxide Solvents: Acetic Acid 标题:Preparation Of Quinolinic And Cinchomeronic Acids By Ozone Oxidation 作者:Lindenstruth,Albert F.; Vanderwerf,Calvin A. 参考文献:Journal Of The American Chemical Society 日期:1949 卷标:71 页码:3020-1]
= 89-00-9 反应条件:1.1 Reagents: Acetic Acid Solvents: Water; 20 °C1.2 Reagents: Hydrogen Peroxide Solvents: Water; 70 °C1.3 Reagents: Sodium Sulfite Solvents: Water 标题:Ozonolysis Of Quinoline And Quinoline Derivatives In A Corning Low Flow Reactor 作者:Lee,Kyoungmi; Lin,Hongkun; Jensen,Klavs F. 参考文献:Reaction Chemistry & Engineering 日期:2017 卷标:2(5) 页码:696-702]
= 89-00-9 反应条件:1.1 Reagents: Potassium Hydroxide,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Water 标题:Aza Analog Of Dithio-β-Isoindigo 作者:Neustroeva,N. R.; Kulikov,M. A.; Vorob'Ev,Yu. G.; Eremina,S. V. 参考文献:Russian Journal Of General Chemistry (Translation Of Zhurnal Obshchei Khimii) 日期:1999 卷标:69(11) 页码:1823-1826]
= 89-00-9 反应条件:1.1 Reagents: Acetic Acid,Sulfuric Acid,Ozone Solvents: Water1.2 Reagents: Hydrogen Peroxide 标题:Ozone 作者:Berglund,Richard A.; Kreilein,Matthew M. 参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2006 卷标:1 页码:1-14
喹啉置于硫酸,双氧水,臭氧体系中,化学反应生成 2,3-吡啶二甲酸 参考文献:Ozonolysis Of Quinolines: A Versatile Synthesis Of Polyfunctional Pyridines 标题:Ozonolysis Of Quinolines: A Versatile Synthesis Of Polyfunctional Pyridines 摘要:描述了一种简单,安全且高效的程序,易于大规模适应,用于合成取代的喹啉2,这些喹啉在矿物酸存在下可被臭氧迅速氧化,随后进行过氧化氢的氧化处理,得到取代的2,3-吡啶二甲酸3A-D,F和酰基吡啶3E,G. DOI:10.1055/s-1989-27423
专利号:US-8680276-B2 优先权日:2009-03-06 标题 :Synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine 发明人:MOTTERLE RICCARDO; ARVOTTI GIANCARLO; BERGANTINO ELISABETTA; CASTELLIN ANDREA; FOGAL STEFANO; GALVAGNI MARCO 权利人:MOTTERLE RICCARDO; ARVOTTI GIANCARLO; BERGANTINO ELISABETTA; CASTELLIN ANDREA; FOGAL STEFANO; GALVAGNI MARCO 摘要:The present invention relates to the stereoselective synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine, as well as the conversion thereof, to give Moxifloxacin. Particularly, the present invention relates to a method for the synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) comprising: (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-2,3-dicarboxylate racemate of formula (II) to give, following isolation, the intermediate dialkyl-(2S,3R)-1-alkylcarbonyl-piperidine-2,3-dicarboxylate of formula (III) in which AIk is a straight or branched C1-C5 alkyl group; (b) the conversion of the intermediate (III) to (4aR,7aS)-1-alkylcarbonylhexahydrofuro[3,4-b]pyridine-5,7-dione of formula (IV) in which AIk has the meanings set forth above; (c) the conversion of the intermediate (IV) to (4aS,7as)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) with an optical purity above 99%.
专利号:US-8735586-B2 优先权日:2007-06-26 标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles 发明人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR 权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA 摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
专利号:WO-2024208876-A1 优先权日:2023-04-03 标题 :Ductile polyamide with the in situ synthesis of a polyimide phase by reactive extrusion 发明人:CASSAGNAU PHILIPPE; DELAGE KARIM; BOUNOR-LEGARE VÉRONIQUE; MARESTIN CATHERINE; DUBOIS CHARLOTTE; GAROIS NICOLAS 权利人:TOTALENERGIES ONETECH; UNIV CLAUDE BERNARD LYON 1 UCBL; CENTRE NAT RECH SCIENT; UNIV JEAN MONNET SAINT ETIENNE UJM; INSTITUT NAT DES SCIENCES APPLIQUEES DE LYON INSA LYON 摘要:The disclosure relates to a ductile polyamide and to a process to produce a ductile polyamide comprising providing components comprising one or more polyamides, one or more dianhydrides, and one or more diamines; wherein the one or more polyamides are provided at a content of at least 60 wt.% based on the total weight of the components; and wherein the one or more polyamides comprise at least one polyamide having amide groups separated by less than 10 carbon atoms; performing in situ synthesis of a polyimide by reactive extrusion of the components wherein the residence time is less than 10 minutes; and recovering a polyamide-polyimide blend being a ductile polyamide comprising a continuous polyamide phase and a dispersed polyimide phase.
专利号:US-12263464-B2 优先权日:2018-03-14 标题 :Method for in-situ synthesis of metal organic frameworks (MOFs), covalent organic frameworks (COFs) and zeolite imidazolate frameworks (ZIFs), and applications thereof 发明人:PAHWA DEEPAK; PAHWA VARUN; CHOUDHARY ANIL KUMAR; SONIA; JHA VIVEK KUMAR; CHAUHAN ANJALI; YADAV ANNU 权利人:DESICCANT ROTORS INTERNATIONAL PRIVATE LTD 摘要:The present invention relates to a method for the in situ synthesis of of MOFs (metal organic frameworks), COFs (covalent organic frameworks), and ZIFs (Zeolitic imidazolate framework), onto and within different types of porous substrates, and their applications. The present invention provides a unique and easy to utilize method by which a number of MOFs, COFs and ZIFs can be synthesized directly onto and within a porous substrate with high performance efficiency ensuring higher grammage in formation of adsorbent product onto and within the substrate.
专利号:US-5002641-A 优先权日:1990-06-28 标题:Electrochemical synthesis of niacin and other N-heterocyclic compounds 发明人:TOOMEY JR JOSEPH E 权利人:REILLY IND INC 摘要:An electrochemical oxidation of a pi-deficient N-heterocyclic precursor compound having an oxidizable organic group attached by a carbon-to-carbon linkage. This precursor compound is at least sparingly water soluble. The preferred electro-oxidation is conducted at an effective anode and in a medium which consists essentially of water, carboxylic acid, and the precursor compound. Preferred are electro-oxidations of substituted pyridine and quinoline bases and a particularly preferred aspect provides a convenient electrochemical synthesis of niacin from 3-methylpyridine.
专利号:EP-2173747-B1 优先权日:2007-06-26 标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles 发明人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS 权利人:SANOFI SA 摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
参考文献:10.1107/s1600536811012360 摘要:Zhang W, Chen Y, Lei T, Li Y, Li W. catena-Poly[diimidazolium [bis-(μ-pyridine-2,5-dicarboxyl-ato)bis-[diaqua-praseodymate(III)]]-bis-(μ-pyridine-2,5-dicarboxyl-ato)]. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):m569–70. 参考文献:10.1107/s1600536811012384 摘要:Manteghi F, Ghadermazi M, Kakaei N. Piperazine-1,4-diium pyridine-2,3-dicarboxyl-ate methanol monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1122. 参考文献:10.1107/s160053681101573x 摘要:Keng TC, Lo KM, Ng SW. Chloridobis(2-chlorobenzyl)(quinolin-8-olato-κ2N,O)tin(IV). Acta Crystallogr E Struct Rep Online. 2011 May 07;67(6):m663. doi: 10.1107/s160053681101573x. 参考文献:10.1155/2011/124256 摘要:Kandasamy M, Reilmann R, Winkler J, Bogdahn U, Aigner L. Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease. Neurology Research International. 2011;2011():1–13. doi: 10.1155/2011/124256. 参考文献:10.1155/2011/901854 摘要:Sengupta A, Basant A, Ghosh S, Sharma S, Sonawat HM. Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria. Journal of Parasitology Research. 2011;2011():1–14. doi: 10.1155/2011/901854.