CAS: 84531-36-2; 6,7-Dihydro-3-Nitro-5H-Cyclopenta[b]Pyridine

该化合物是一种环环有机化合物,其特点是其双环结构,由环球环组成,环球环组成,在三处有一个硝基化合物组,有助于其反应和各种化学反应的潜在应用.该化合物通常显示黄色至褐色的黄色至褐色,在有机溶剂中溶解.其分子结构具有独特的电子特性,使其对医药化学和材料科学感兴趣.该化合物可能由于硝基苯组的电脱衣性质而参与电子哲学替代反应.此外,该化合物可能展示生物活动,值得进一步调查潜在的药物应用.应当参考安全数据,因为硝基化合物可能危险,应当遵循适当的处理程序.

结构式图片

相似化合物

178209-29-5 533-37-9 858296-81-8

物理性质

MSDS等安全信息

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CAS号14150-94-8 1-甲基-3,5-二硝基-1H... | CAS号108-94-1 环己酮 | CAS号936-52-7 1-吗啉-1-环戊烯 | CAS号120-92-3 环戊酮 | CAS号1614-92-2 1-(1-环戊烯基)哌啶 | CAS号14080-32-1 5-硝基嘧啶 | CAS号7148-07-4 1-吡咯烷基-1-环戊烯 | CAS号178209-29-5 6,7-二氢-5H-环戊并[b...

合成工艺路线路线简述

  • 120-92-3 + 14150-94-8 = 84531-36-2
    反应条件:1.1 Reagents: Ammonium Acetate Solvents: Ethanol; 2 H,65 °C
    标题:An Efficient Synthesis Of Nitrated Cycloalka[b]Pyridines
    作者:Le,Song Thi; Et Al
    参考文献:Synthesis 日期:2014 卷标:46(16) 页码:2175-2178]

    7148-07-4 + 1239883-74-9 = 84531-36-2
    反应条件:1.1 Solvents: Chloroform; 23 °C; 23 °C -> 60 °C; 2 H,60 °C; Cooled
    标题:Synthesis,Characterization,And Rapid Cycloadditions Of 5-Nitro-1,2,3-Triazine
    作者:Glinkerman,Christopher M.; Et Al
    参考文献:Organic Letters 日期:2018 卷标:20(9) 页码:2628-2631]

    7148-07-4 + 14080-32-1 = 84531-36-2
    反应条件:1.1 Solvents: Ethanol
    标题:Inverse Electron Demand Diels-Alder Reactions Of 5-Nitropyrimidine With Enamines. Synthesis Of 3-Nitropyridine Derivatives
    作者:Marcelis,Antonius T. M.; Et Al
    参考文献:Tetrahedron 日期:1989 卷标:45(9) 页码:2693-702]

    126215-88-1 = 84531-36-2
    反应条件:1.1 Solvents: Nitrobenzene
    标题:Intramolecular Diels-Alder Reactions Of 2-(Alkynyl)Pyrimidines And 2-(Alkynyl)Pyridines
    作者:Frissen,A. E.; Et Al
    参考文献:Tetrahedron 日期:1989 卷标:45(16) 页码:5151-62]

    88499-78-9 + 14080-32-1 = 84531-36-2
    反应条件:1.1 Reagents: Triethylamine Solvents: Ethanol2.1 Solvents: Nitrobenzene
    标题:Intramolecular Diels-Alder Reactions Of 2-(Alkynyl)Pyrimidines And 2-(Alkynyl)Pyridines
    作者:Frissen,A. E.; Et Al
    参考文献:Tetrahedron 日期:1989 卷标:45(16) 页码:5151-62]

    7148-07-4 + 14080-32-1 = 84531-36-2 [标题:Reaction Conditions
    标题:Pyrimidines. Part 93. Ring Transformations Of Heterocycles. Part 28. Ring Transformations Of 5-Nitropyrimidine Via Inverse Diels-Alder Reactions
    作者:Charushin,Valery N.; Et Al
    参考文献:Tetrahedron Letters 日期:1982 卷标:23(38) 页码:3965-8]

    126215-88-1 = 84531-36-2
    反应条件:1.1 Solvents: Nitrobenzene
    标题:Intramolecular Inverse Electron Demand Diels-Alder Reactions Of Pyrimidines
    作者:Frissen,A. E.
    参考文献:1990]

    936-52-7 + 1239883-74-9 = 84531-36-2
    反应条件:1.1 Solvents: Chloroform; 23 °C; 23 °C -> 60 °C; 24 H,60 °C; Cooled
    标题:Synthesis,Characterization,And Rapid Cycloadditions Of 5-Nitro-1,2,3-Triazine
    作者:Glinkerman,Christopher M.; Et Al
    参考文献:Organic Letters 日期:2018 卷标:20(9) 页码:2628-2631]

    88499-78-9 + 14080-32-1 = 84531-36-2
    反应条件:1.1 Reagents: Triethylamine Solvents: Acetic Acid2.1 Solvents: Nitrobenzene
    标题:Intramolecular Inverse Electron Demand Diels-Alder Reactions Of Pyrimidines
    作者:Frissen,A. E.
    参考文献:1990]

    3994-40-9 = 84531-36-2
    反应条件:1.1 Reagents: Sodium Periodate Solvents: Dichloromethane,Water; 3 Min,Rt2.1 Solvents: Chloroform; 23 °C; 23 °C -> 60 °C; 2 H,60 °C; Cooled
    标题:Synthesis,Characterization,And Rapid Cycloadditions Of 5-Nitro-1,2,3-Triazine
    作者:Glinkerman,Christopher M.; Et Al
    参考文献:Organic Letters 日期:2018 卷标:20(9) 页码:2628-2631]

    2075-46-9 = 84531-36-2
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydroxylamine-O-Sulfonic Acid Solvents: Water; 10 Min,Rt; Rt -> 60 °C; 5 H,60 °C; Cooled2.1 Reagents: Sodium Periodate Solvents: Dichloromethane,Water; 3 Min,Rt3.1 Solvents: Chloroform; 23 °C; 23 °C -> 60 °C; 2 H,60 °C; Cooled
    标题:Synthesis,Characterization,And Rapid Cycloadditions Of 5-Nitro-1,2,3-Triazine
    作者:Glinkerman,Christopher M.; Et Al
    参考文献:Organic Letters 日期:2018 卷标:20(9) 页码:2628-2631]

    7148-07-4 + 14080-32-1 = 84531-36-2 [标题:Reaction Conditions
    标题:The Retro-Diels-Alder Reaction. Part Ii. Dienophiles With One Or More Heteroatom
    作者:Rickborn,Bruce
    参考文献:Organic Reactions (Hoboken 日期:1998 卷标:53
📜5-硝基-2-(戊-4-炔-1-基)嘧啶 以 硝基苯 作为反应溶剂,化学反应 0.5H,以58%的收率获得产物3-硝基-6,7-二氢-5-氢-环戊烷[b]吡啶
参考文献:2-(炔基)嘧啶和2-(炔基)吡啶的分子内diels-Alder反应
标题:2-(炔基)嘧啶和2-(炔基)吡啶的分子内diels-Alder反应
摘要:嘧啶3,7和13携带ω-炔基侧链-Cr 2(ch 2)ñ Ch 2 Cch(r = H,Cn; N = 1时,2)在2位上进行分子内逆电子需求跨c-2和c-5位置的diels-Alder反应.氰化氢的损失,通过逆狄尔斯-阿尔德反应引起的,从中间cycloadducts导致稠合吡啶5,9和15分别.类似地,由硝基吡啶16中的2,3-二氢硝基-1 H-茚18获得.讨论了电子效应和空间效应对环加成速率的影响.连接反应中心的链上的宝石二取代导致化合物3与13的速率显着提高.在二烯和亲二烯体之间的系链中具有额外亚甲基的化合物7,由于熵助的降低,其反应比化合物3慢得多.
DOI:10.1016/s0040-4020(01)81093-0

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主要参考文献

参考标题:Nucleophilic Reaction Upon Electron-Deficient Pyridone Derivatives. X.One-Pot Synthesis Of 3-Nitropyridines By Ring Transformation Of 1-Methyl-3,5-Dinitro-2-Pyridone With Ketones Or Aldehydes In The Presence Of Ammonia
作者:Yasuo Tohda,Miyuki Eiraku,Takao Nakagawa,Yumi Usami,Masahiro Ariga,Toshihide Kawashima,Keita Tani,Hiroko Watanabe,Yutaka Mori |发布日期:1990.10
摘要:The Reaction Of 1-Methyl-3,5-Dinitro-2-Pyridone (1A) With Ketones Or Aldehydes In The Presence Of Ammonia Gave Alkyl- And/or Aryl-Substituted 3-Nitropyridines (6) In Moderate To High Yields. Enamines Derived From The Ketones Gave Better Results Than Did The Ketones Themselves; On The Other Hand, Those Derived From The Aldehydes Gave No 6 At All. On The Basis Of Deuterium-Labeled Experiments, A Mechanism Comprising Competitive Ring Transformations Of 1A Is Proposed.

合成参考文献


摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 30.
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