CAS: 82209-72-1; 3-(2-((1R,4As,5R,6R,8As)-6-Hydroxy-5,8A-Dimethyl-2-Methylene-5-((((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Decahydronaphthalen-1-yl)Ethyl)Furan-2(5H)-One
该化合物是一个复杂的有机化合物,其特点是分子结构复杂,包括多个手性中心和功能组;该化合物具有葡萄糖色谱色素的特性,表明它是葡萄糖的胶层,有助于其溶解性和潜在的生物活动;一个氢氧基组的存在表明,它可能具有氢联结能力,影响其在生物系统中的相互作用;此外,引信环系统和各种替代体意味着它可能拥有独特的立体化学特性,有可能影响其再活性和药理学特征;这些化合物由于其潜在的治疗用途,往往对药用化学和天然产品合成感兴趣;总体而言,该物质的结构复杂性和功能多样性使得它成为各种化学和生物环境进一步调查的候选物.
- 英文名称3-(2-((1R,4As,5R,6R,8As)-6-Hydroxy-5,8A-Dimethyl-2-Methylene-5-((((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Decahydronaphthalen-1-yl)Ethyl)Furan-2(5H)-One
- 中文名称穿心莲内酯
- IUPAC名称3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5,8a-dimethyl-2-methylene-5-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)decahydronaphthalen-1-yl)ethyl)furan-2(5H)-one
- 其它别名14-Deoxyandrographoside; Andropanoside; Ninandrographolide; 2(5H)-Furanone, 3-[2-[(1R,4As,5R,6R,8As)-5-[(β-D-Glucopyranosyloxy)Methyl]Decahydro-6-Hydroxy-5,8A-Dimethyl-2-Methylene-1-Naphthalenyl]Ethyl]-; Deoxyandrographoside
- CAS编号82209-72-1
- MFCD编号:MFCD23103724
- FDA UNII编号:Z87B39FVT4
- 分子式:C26H40O9分子量:496.6
- 产品CID: 1813522
- 产品分类天然产物 → 萜类
物理性质
MSDS等安全信息
上下游产品
UDP-glucose iso-14-deoxyandrographolide合成工艺路线路线简述
📜尿苷(5')二氢二磷酰(1)-Alpha-D-葡萄糖,去氧穿心莲内酯置于glucosyltransferase From Andrographis Paniculata体系中,用 Aq. Buffer 作为反应溶剂,化学反应 12.0H,反应生成 穿心莲内酯
参考文献:Glucosyltransferase Capable Of Catalyzing The Last Step In Neoandrographolide Biosynthesis
标题:Glucosyltransferase Capable Of Catalyzing The Last Step In Neoandrographolide Biosynthesis
摘要:Apugt,A Diterpene Glycosyltransferase From Andrographis Paniculata,Could Transfer A Glucose To The C-19 Hydroxyl Moiety Of Andrograpanin To Form Neoandrographolide. This Glycosyltransferase Has A Broad Substrate Scope,And It Can Glycosylate 26 Natural And Unnatural Compounds Of Different Structural Types. This Study Provides A Basis For Exploring The Glycosylation Mechanism Of Ent-Labdane-Type Diterpenes And Plays An Important Role In Diversifying The Structures Used In Drug Discovery.
DOI:10.1021/acs.Orglett.8B02146
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905310000-1,2-乙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1021/np050160u.s001
摘要:ent-Labdane Diterpenoids from Andrographis paniculata^. (). doi: 10.1021/np050160u.s001.
参考文献:10.1002/chin.201029197
摘要:Kulyal P, Tiwari UK, Shukla A, Gaur AK. ChemInform Abstract: Chemical Constituents Isolated from Andrographis paniculata. ChemInform. 2010 Jun 24;41(29). doi: 10.1002/chin.201029197.
参考文献:10.1248/cpb.32.2117
摘要:FUJITA T, FUJITANI R, TAKEDA Y, TAKAISHI Y, YAMADA T, KIDO M, MIURA I. On the diterpenoids of Andrographis paniculata: X-ray crystallographic analysis of andrographolide and structure determination of new minor diterpenoids. Chem. Pharm. Bull. 1984;32(6):2117–25. doi: 10.1248/cpb.32.2117.
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