CAS: 80789-69-1; 1-(4-Chlorophenyl)Cyclopentanecarboxylic Acid

该化合物是一种替代环丙烷箱状酸衍生物,在1号位置上有一个4-氯苯组,该化合物是有机合成的多用途中间体,特别是在制药和农用化学品开发方面,其硬性环丙烷脊椎和芳香化氯联苯替代成分增强了结构稳定性,使其有利于设计生物活性分子.箱式酸功能组允许进一步衍生,从而形成酯,氨或其他衍生物.其明确界定的结构和纯度使其适合医药化学的研究应用,而精确的分子修改至关重要.该化合物通常以高纯度供应,以确保合成工作流程的一致性.

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上下游产品

CAS号64399-26-4 1-(4-氯苯基)环戊烷-1-腈 | CAS号140-53-4 对氯苯乙腈 | CAS号71501-44-5 1-(4-氯苯基)-1-环戊羰酰氯 | CAS号80866-79-1 1-(p-chlorophen...

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  • 140-53-4 + 110-52-1 = 80789-69-1
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethylformamide; 0.5 H,Rt1.2 4 H,50 - 55 °C2.1 Reagents: Potassium Hydroxide Solvents: Ethylene Glycol; 9 H,Reflux
    标题:Synthesis And Biological Activity Of Arylcyclopentane-1-Carboxylic Acids Aminoesters
    作者:Aghekyan,A. A.; Et Al
    参考文献:Russian Journal Of General Chemistry 日期:2019 卷标:89(5) 页码:1051-1054]

    64399-26-4 = 80789-69-1
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Ethylene Glycol; 9 H,Reflux
    标题:Synthesis And Biological Activity Of Arylcyclopentane-1-Carboxylic Acids Aminoesters
    作者:Aghekyan,A. A.; Et Al
    参考文献:Russian Journal Of General Chemistry 日期:2019 卷标:89(5) 页码:1051-1054]

    64399-26-4 = 80789-69-1
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Water
    标题:Synthesis And Antibacterial Properties Of Halo-Containing 1-Phenylcyclopentyl-1-Penicillins And -1-Cephalosporins
    作者:Mndzhoyan,Sh. L.; Et Al
    参考文献:Khimiko-Farmatsevticheskii Zhurnal 日期:1992 卷标:26(2) 页码:54-7]

    64399-26-4 = 80789-69-1 [标题:Reaction Conditions
    标题:Solvolysis Reactions: Relative Abilities Of Cyclopentyl/phenyl Groups To Stabilize An Electron-Deficient Carbon
    作者:Roberts,Donald D.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1994 卷标:59(21) 页码:6464-9
📜对氯苯乙腈置于potassium Hydroxide,Sodium Hydroxide体系中,用 乙二醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 13.5H,反应生成 1-(4-氯苯基)-1-环戊烷甲酸
参考文献:Synthesis And Biological Activity Of Arylcyclopentane-1-Carboxylic Acids Aminoesters
标题:Synthesis And Biological Activity Of Arylcyclopentane-1-Carboxylic Acids Aminoesters
摘要:1-Arylcyclopentane-1-Carboxylic Acids Were Synthesized By Alkaline Hydrolysis Of The Corresponding Nitriles. Reactions Of The Acid Chlorides With N,N-Dialkylaminoalkyl-And Hetarylalkylalkanols Provided New Aminoester Derivatives Of 1-Arylcyclopentane-1-Carboxylic Acids. Sympatholytic And Adrenolytic Activity Of The Obtained Amino Esters Hydrochlorides Was Studied.
DOI:10.1134/s107036321905027X

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专利信息


专利号:US-7511141-B2
优先权日:2001-03-02
标题 :Piperidine-piperazine ligands for neurotransmitter receptors
发明人：PERSONS PAUL E; RADEKE HEIKE
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to piperidine-piperazine compounds. A second aspect of the present invention relates to the use of the piperidine-piperazine compounds as ligands for various mammalian cellular receptors or transporters or both, including dopamine, serotonin or norepinephrine receptors or transporters, any combination of them, or all of them. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the piperidine-piperazine compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine receptors or transporters or both.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

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合成参考文献


摘要:Li, D.-D.; Wang, G.-W., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 365.
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