专利号:US-6664282-B2 优先权日:1999-09-17 标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds 发明人:ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TORREY PINES INST 摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.
专利号:US-5856107-A 优先权日:1997-02-04 标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein 发明人:OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TREGA BIOSCIENCES INC 摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.
专利号:US-12180188-B2 优先权日:2020-05-19 标题:Antifibrotic compounds and related methods 发明人:STEFANOVIC BRANKO; NEFZI ADEL 权利人:UNIV FLORIDA STATE RES FOUND; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES 摘要:This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.
专利号:EP-1218337-A1 优先权日:1999-09-17 标题 :Synthesis of 3,5,7]-1h-imidazo 1,5-a]imidazol-2(3h)-one compounds
专利号:US-6545032-B1 优先权日:1999-09-17 标题:Synthesis of [3,5,7]-H-imidazo[1,5-a] imidazol-2(3H)-one compounds
专利号:US-2002193608-A1 优先权日:1999-09-17 标题 :Synthesis of [3,5,7]--1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
参考标题:A Rhodium-Catalyzed Cascade Cyclization: Direct Synthesis OfN-Substituted Phthalimides From Isocyanates And Benzoic Acids 作者:Xian-Ying Shi,Andrea Renzetti,Soumen Kundu,Chao-Jun Li |发布日期:2014.3.10 摘要:A Rhodium(III)‐catalyzed Amidation Between Benzoic Acids And Isocyanates Via Direct Functionalization Of An Ortho Ch Bond Followed By Intramolecular Cyclization Is Described. This Cascade Cyclization Affords N‐substituted Phthalimides In One Step In 26-91% Yields. The Reaction Is Highly Atom‐economical, Since No Theoretical Waste Except For Water Is Generated In The Reaction.
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198