CAS: 68039-47-4; (2-Isopropoxyethyl)Benzene

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上下游产品

苯乙醇 2-Phenylethanol 60-12-8
苯乙酸异丙酯 Isopropyl Phenylacetate 4861-85-2
2-异丙氧基-1-苯基乙醇 2-Isopropoxy-1-Phenylethanol 3578-32-3

合成工艺路线路线简述

    📜2-碘代乙基苯置于锌体系中,用 异丙醇 作为反应溶剂,化学反应 20.0H,以55%的收率获得产物[2-(1-甲乙氧基)乙基]苯
    参考文献:Photolysis Of 2-Phenylethyl And 4-Phenyl-1-Butyl Halides In Alcoholic Solvents
    标题:Photolysis Of 2-Phenylethyl And 4-Phenyl-1-Butyl Halides In Alcoholic Solvents
    摘要:
    DOI:10.1016/s0040-4020(01)87368-3

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    专利信息


    专利号:US-2005214310-A1
    优先权日:2004-01-23
    标 题 :Melphalan prodrugs
    发明人:TOKI BRIAN E; SENTER PETER D
    权利人:SEATTLE GENETICS INC
    摘要:Shown and described are the synthesis of more potent forms of C-Mel, a prodrug used in Antibody-Directed Enzyme Prodrug Therapy, that releases the clinically used anticancer alkylating agent melphalan extracellularly. Shown and described are the synthesis of a variety of melphalan analogues with the intention to promote facile intracellular drug access. Esters, amides, and peptides of melphalan are shown. Cephalosporin prodrugs of the most interesting melphalan derivatives were synthesized and evaluated for potency, toxicity, therapeutic window, plasma stability, and solubility.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Patil, N. T.; Bera, P.; Paroi, B., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .
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