CAS: 57333-96-7; (1R,3S,5Z)-5-[(2E)-2-[(1R,3As,7Ar)-1-[(2R,5R)-5-Hydroxy-6-Methylheptan-2-Yl]-7A-Methyl-2,3,3A,5,6,7-Hexahydro-1H-Inden-4-Ylidene]Ethylidene]-4-Methylidenecyclohexane-1,3-Diol

上下游产品

(1S,3R,5E,7E)-1,3-二-[(叔-丁基二甲基硅烷基)氧基]-9,10-开环孕甾-5,7,10-三烯-20-甲醛 (5E,7E)-(1S,3R,20S)-1,3-Bis<<(1,1-Dimethylethyl)Dimethylsilyl>Oxy>-20-Methyl-9,10-Secopregna-5,7,10(19)-Trien-21-Al 112828-13-4

De-A,B-(24R)-24-[(Methoxymethyl)Oxy]-Cholestan-8-One置于正丁基锂,氢氟酸,四丁基氟化铵体系中,用 四氢呋喃,水,乙腈 作为反应溶剂,化学反应 42.0H,反应生成 他卡西醇
参考文献:修饰的julia烯化和α氨氧基化反应介导1α,24(R)-二羟基维生素d 3(他骨化醇)的收敛合成
标题:修饰的julia烯化和α氨氧基化反应介导1α,24(R)-二羟基维生素d 3(他骨化醇)的收敛合成
摘要:从廉价的和可商购的异戊醛和容易获得的inhoffen-Lythgoe二醇开始,已经实现了塔骨化醇的收敛合成.关键步骤包括脯氨酸催化的α氨氧基化和julia-Kocienski烯烃化.
DOI:10.1016/j.Tetlet.2017.07.103

专利信息

专利号:WO-2025108575-A1
优先权日:2023-11-21
标 题:Methods of selective deprotection and synthesis of transhydrindane- skeleton-based compounds
发明人：HUBER FLORIAN MAURITIUS ERASMUS
权利人:ROCHE DIAGNOSTICS GMBH
摘要:The present invention relates to methods of selectively deprotecting a transhydrindane-skeleton-based compound comprising at least two different silyl ether groups. The present invention further relates to methods of synthesizing a Vitamin D molecule and to Vitamin D molecules obtainable by such processes. Furthermore, the present invention relates to a compound according to formula (I) comprising two different silyl ether groups, its use in the synthesis of Vitamin D molecules and to methods of producing such a compound.

专利号:US-6610866-B2
优先权日:1996-12-06
标 题 :Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
发明人：KINNEY WILLIAM A; JONES STEVEN; ZHANG XUEHAI; RAO MEENA N; BULLIARD MICHEL; MECKLER HAROLD; LEE NANCY
权利人:MAGAININ PHARMA
摘要:A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces the unsaturated alkyl ketone to an unsaturated alkyl alcohol. The unsaturated alkyl alcohol can be further reduced, if desired, to produce a saturated alkyl alcohol. The fused ring base can be, for example, a steroid ring base or a base of a vitamin D analog. The process in accordance with the invention can be used with an alkeneone substituent (e.g., a 22-ene-24-one substituent) or an alkyneone substituent (e.g., a 22-yne-24-one substituent) on a steroid ring base to make squalamine or other useful aminosterol compounds and intermediates for making aminosterol compounds.

专利号:EP-1389623-B1
优先权日:1996-12-06
标题 :Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin d analogs, and other compounds
发明人：KINNEY WILLIAM A; JONES STEVEN; ZHANG XUEHAI; RAO MEENA N; BULLIARD MICHEL; MECKLER HAROLD; LEE NANCY
权利人:OHR PHARMACEUTICAL INC

专利号:JP-2009138000-A
优先权日:1996-12-06
标题 :Stereoselective synthesis of 24-hydroxylated compounds useful for the production of aminosterols, vitamin D analogs and other compounds

专利号:CN-105439927-A
优先权日:2014-09-29
标题 :A kind of preparation method of enantioselective synthesis of tacalcitol

专利号:WO-9824800-A2
优先权日:1996-12-06
标题 :Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin d analogs, and other compounds