专利号:US-4546198-A 优先权日:1983-01-18 标 题 :Asymmetric synthesis of esters and acids 发明人:STOUTAMIRE DONALD W 权利人:SHELL OIL CO 摘要:Stereoisomerically-enriched esters are prepared by treating a non-symmetrical ketene with a racemic or chiral tertiary-base-substituted alkylcarbinol. Optional hydrolysis of the esters gives the corresponding optically-active carboxylic acids corresponding to the non-symmetrical ketene.
专利号:EP-1021457-B1 优先权日:1996-07-05 标题 :Method for the site specific synthesis of novel 3-hydroxypyridin-4(1h)-ones derivatives from aminoitols, products obtained by this method and their applications
专利号:FR-2750699-A1 优先权日:1996-07-05 标 题:REGIOSPECIFIC SYNTHESIS OF NEW 3-HYDROXYPYDIRIN-4 (1H) -ONES DERIVATIVES FROM AMINOMONOSACCHARIDES OR AMINOITOLS. PRODUCTS OBTAINED BY THIS PROCESS AND THEIR APPLICATIONS
专利号:WO-9725992-A1 优先权日:1996-01-16 标 题 :Tocolytic oxytocin receptor antagonists 发明人:SPARKS MICHELLE A; FRIEDINGER ROGER M; PERLOW DEBRA S; WILLIAMS PETER D 权利人:MERCK & CO INC; SPARKS MICHELLE A; FRIEDINGER ROGER M; PERLOW DEBRA S; WILLIAMS PETER D 摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
专利号:CN-111646889-A 优先权日:2020-04-29 标题:Green Synthesis Method of Pharmaceutical Active Molecules GC-24 and Furugrelic Acid
专利号:US-5726172-A 优先权日:1996-01-16 标题 :Tocolytic oxytocin receptor antagonists 发明人:SPARKS MICHELLE A; FREIDINGER ROGER M; PERLOW DEBRA S; WILLIAMS PETER D 权利人:MERCK & CO INC 摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery. A typical compound is as follows:
参考文献:10.1007/bf00639810 参考文献:10.1007/bf00761096 摘要:Trubnikov VI, Zhdanovich ES, Preobrazhenskii NA. Investigations in the field of pyridinecarboxylic acids. III. Gas-liquid chromatography in the production of nicotinic and isonicotinic acids from the β-picoline fraction. Pharmaceutical Chemistry Journal. 1968 Jan;2(1):27–9. doi: 10.1007/bf00761096.