专利号:US-3721650-A 优先权日:1971-03-22 标题 :Reactive hydroxyalkyl-onium catalysts for synthesis of polyoxazolidones 发明人:D ALELIO G 权利人:ALELIO G D 摘要:A PROCESS FOR PREPARING POLYOXAZOLIDONES IS PROVIDED IN WHICH A POLYEPOXIDE IS REACTED WITH A POLYISOCYANATE IN THE PRESENCE OF CHEMICALLY REACTIVE HYDROXYALKYL-ONIUM CATALYSTS, SELECTED FROM THE CLASS OF AMMONIUM AND PHOSPHONIUM HALIDES HAVING AT LEAST TWO HYDROXYALKYL GROUPS. NOVEL POLYMERS ARE OBTAINED WHEN THESE NEW CATALYSTS CONTAINING TWO OR MORE HYDROXY GROUPS ARE CONDENSED WITH POLYISOCYANATES.
专利号:WO-2004074295-A1 优先权日:2003-02-21 标题:Thiazole cycle polymers, process for producing the same, synthesis intermediates thereof and utilization of the same 发明人:TOSHIMA KAZUNOBU 权利人:UNIV KEIO; TOSHIMA KAZUNOBU 摘要:A novel thiazole cycle polymer represented by the following general formula (I) or its pharmacologically acceptable salt: (I) wherein R’s independently represent each hydrogen, optionally substituted lower alkyl, -CH2SH, formyl or carboxyl; and n is an integer of from 1 to 4. A process for producing the above compound, an intermediate in the synthesis thereof and a telomerase inhibitor and a medicinal composition containing the same. The above compound selectively acts on telomerase (i.e., having a high telomerase inhibitory effect with little inhibitory effects on Taq polymerase and other reverse transcriptases) and has no or little toxicity, which makes it highly useful as a selective telomerase inhibitor.