CAS: 5400-80-6; 2-Bromo-1-Indanol

该化合物其结构特征为其结构特征,其结构特征是附于因地醇框架第二个碳的溴原子,该化合物属于异地醇类,该类物为异地醇的衍生物,在第一个位置是丁烷与氢氧基(OH)组(OH)的衍生物,溴基分成分的存在具有显著的再活性,使其在各种化学反应中有用,包括核嗜好替代和混合反应. 2-Bromo-1-indanol在室温中通常是固体,在有机溶剂中可溶解,反映了其因异地环系统造成的疏水性,其分子配有碳和氢原子,以及溴和氧,有助于其独特的化学特性.该化合物对合成有机化学具有兴趣,并可作为合成更复杂的分子的中间体.在处理该化合物时,应当注意安全防范,因为溴化化合物可能对健康造成危害.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号95-13-6 茚 | CAS号1775-27-5 2-溴-1-茚满酮 | CAS号67-56-1 甲醇 | CAS号506-68-3 溴化氰 | CAS号79-15-2 N-溴代乙酰胺 | CAS号20357-79-3 1,2-二溴茚烷 | CAS号67-64-1 丙酮 | CAS号7732-18-5 水 | CAS号768-22-9 6,6A-二氢-1AH-茚并[... | CAS号10485-09-3 2-溴化茚 | CAS号615-13-4 2-茚酮 | CAS号1579-15-3 (3-oxo-1,2-dihy... | CAS号1775-27-5 2-溴-1-茚满酮 | CAS号71436-67-4 2-溴-3-氯萘 | CAS号80228-36-0 3-Chloronaphtha...

合成工艺路线路线简述

    📜茚置于n-溴代丁二酰亚胺(Nbs),Ammonium Acetate体系中,用 水,丙酮 作为反应溶剂,化学反应生成 2-溴-1-茚醇
    参考文献:无机次磷酸钠合成β-羟基氢膦酸
    标题:无机次磷酸钠合成β-羟基氢膦酸
    摘要:以绿色,廉价,安全的无机盐连二磷酸钠为磷源,在三氟甲磺酸银作为催化剂存在下,通过易得环氧化物的开环反应,报道了一种制备β-羟基氢膦酸衍生物的有效方法.该反应操作简单,具有优异的选择性和非常好的官能团相容性.
    DOI:10.1055/a-2133-1963

    海关参考信息

    专利信息


    专利号:US-6960601-B2
    优先权日:2001-09-24
    标题 :Preparation and use of imidazole derivatives for treatment of obesity
    发明人：SMITH ROGER A; O'CONNOR STEPHEN J; WIRTZ STEPHAN-NICHOLAS; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C E; SU NING; WANG GAN; ACHEBE FURAHI; YING SHIHONG
    权利人:BAYER PHARMACEUTICALS CORP
    摘要:This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

    专利号:US-5612484-A
    优先权日:1995-05-18
    标题:Process for making HIV protease inhibitors
    发明人：ASKIN DAVID; SAGER JESS; ROSSEN KAI; VOLANTE RALPH P; REIDER PAUL J
    权利人:MERCK & CO INC
    摘要:A process for making a clinically efficacious HIV protease inhibitor Compound J eliminates one step in its synthesis, by an improved, alternative synthesis of the 2(S)-4-picolyl-2-piperazine-t-butyl-carboxamide intermediate.

    专利号:US-5489710-A
    优先权日:1994-03-11
    标题 :Regiospecific processes to make cis-1-amino-2-alkanol from diol
    发明人：VERHOEVEN THOMAS R; ROBERTS F EDWARD; SENANAYAKE CHRIS H; RYAN KENNETH M
    权利人:MERCK & CO INC
    摘要:A regioselective processes are disclosed for the synthesis of (1R,1S)-amino-(2S,2R)-alkanol, particularly (1R,1S)-amino-(2S,2R)-indanol.

    专利号:US-6156895-A
    优先权日:1998-02-02
    标 题:Process for preparing 4-tert-butyloxycarbonyl-(S)-piperazine-2-tert-butylcarboxamide
    发明人：ROSSEN KAI; PYE PHILIP J; VOLANTE RALPH P; REIDER PAUL J
    权利人:MERCK & CO INC
    摘要:An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butylcarboxamide, an intermediate for an HIV protease inhibitor.

    专利号:US-5723615-A
    优先权日:1995-06-28
    标 题 :Process for preparing 4-tert-butyloxycarbonyl-(S)-piperazine-2-tert-butylcarboxamide
    发明人：ROSSEN KAI; WEISSMAN STEVEN A; SAGER JESS; ASKIN DAVID; REIDER PAUL J; VOLANTE RALPH P
    权利人:MERCK & CO INC
    摘要:An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butyl-carboxamide, an intermediate for an HIV protease inhibitor.

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献

    参考DOI号:10.1016/j.tetlet.2009.03.047
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知