CAS: 52711-92-9; 2-(2,5-Dimethoxyphenyl)Acetyl Chloride

该化合物是一种多用途乙基氯衍生物,主要用作有机合成的关键中间体;其活性碳基氯化物组群能够产生高效的相互碰撞反应,使其对构建复杂的分子,特别是在制药和农用化学研究中,具有价值;甲氧基替代体增强了其富电子芳香特性,影响电益替代中的回动性和选择性;该化合物由于其湿度敏感,通常在水性条件下处理.其高纯度和一贯性能使其适合精确的合成应用,包括制备活性药物成分和特殊化学品.适当的储存和处理对于保持稳定性和回性至关重要.

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CAS号1758-25-4 2,5-二甲氧基苯基乙酸 | CAS号66469-86-1 2,5-二甲氧苯基乙酸乙酯 | CAS号7417-19-8 2,5-二甲氧基苯乙醇 | CAS号76196-46-8 Benzeneacetic a... | CAS号894802-86-9 4-(2,5-dimethox...

合成工艺路线路线简述

    📜Methyl (2,5-Dimethoxyphenyl)Acetate置于氢氧化钾,氯化亚砜体系中,用 苯 作为反应溶剂,化学反应 7.0H,反应生成 (2,5-二甲氧苯基)乙酰氯
    参考文献:Kong,Josephine L. Y.; Loach,Paul A.,Journal Of Heterocyclic Chemistry,1980,Vol. 17,P. 737-744
    标题:Kong,Josephine L. Y.; Loach,Paul A.,Journal Of Heterocyclic Chemistry,1980,Vol. 17,P. 737-744

    海关参考信息

    专利信息


    专利号:US-6608196-B2
    优先权日:2001-05-03
    标题 :Process for solid supported synthesis of pyruvate-derived compounds
    发明人:WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
    权利人:GALILEO PHARMACEUTICALS INC
    摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

    专利号:US-6413957-B1
    优先权日:1998-04-21
    标题:Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones
    发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
    权利人:BRISTOL MYERS SUIBB PHARMA COM
    摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

    专利号:US-7250435-B2
    优先权日:1999-10-20
    标 题:Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
    发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP P; YUE EDDY
    权利人:BRISTOL MYERS SQUIBB PHARMA CO
    摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n nthat are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.n n This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

    专利号:US-6407103-B2
    优先权日:1998-04-21
    标 题:Indeno [1,2-c] pyrazol-4-ones and their uses
    发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
    权利人:BRISTOL MYERS SQUIBB PHARMA CO
    摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

    专利号:US-6593356-B2
    优先权日:1999-10-20
    标 题 :Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
    发明人:NUGIEL DAVID; CARINI DAVID; DIMEO SUSAN; VIDWANS ANUP; YUE EDDY
    权利人:BRISTOL MYERS SQUIBB PHARMA CO
    摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

    专利号:RU-2194044-C2
    优先权日:1997-10-01
    标 题 :Derivatives of benzamidine, method of their synthesis and pharmaceutical composition

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    合成参考文献


    参考文献:10.1107/s1600536812008975
    摘要:Choi H, Shim YS, Han BH, Kang SK, Sung CK. 2-(2,5-Dimeth-oxy-phen-yl)-N-[2-(4-hy-droxy-phen-yl)eth-yl]acetamide. Acta Crystallogr Sect E Struct Rep Online. 2012 Apr 01;68(Pt 4):o966.
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